scholarly journals Preparation of Orally Disintegrating Tablets with Taste-masking Function: Masking Effect in Granules Prepared with Correctives Using the Dry Granulation Method and Evaluation of Tablets Prepared Using the Taste-masked Granules

2010 ◽  
Vol 130 (1) ◽  
pp. 81-86 ◽  
Author(s):  
Yayoi KAWANO ◽  
Akihiko ITO ◽  
Masanaho SASATSU ◽  
Yoshiharu MACHIDA
Keyword(s):  
Masking Effect ◽  
Taste Masking ◽  
Dry Granulation ◽  
Orally Disintegrating Tablets ◽  
Masking Function

scholarly journals A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets

2016 ◽  
Vol 66 (4) ◽  
pp. 515-532 ◽  
Author(s):  
Ahmed Refaat ◽  
Magda Sokar ◽  
Fatma Ismail ◽  
Nabila Boraei
Keyword(s):  
Sustained Release ◽  
Masking Effect ◽  
Taste Masking ◽  
Atypical Antipsychotic Drug ◽  
Disintegration Time ◽  
Orally Disintegrating Tablets ◽  
Dual Strategy ◽  
Wetting Time ◽  
Croscarmellose Sodium ◽  
Hot Melt

Abstract Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared using the hot melt extrusion technique and utilizing three lipid carriers: Compritol, Precirol and white beeswax either alone or in mixtures. They showed sustained QT release and a taste masking effect. The selected QT SLMP was further blended with an aqueous solution containing polyvinylpyrollidone (2.5 %), croscarmellose sodium (2 %) and mannitol (50 %); it was then lyophilized into ODT in a mass ratio of 1:2, respectively. ODTs containing QT SLMPs showed: average wetting time (40.92 s), average oral disintegration time (21.49 s), average hardness (16.85 N) and also imparted suitable viscosity to suspend pellets during the lyophilization process. In conclusion, lyophilization is a promising technique for the formulation of multiparticulate systems into ODTs.

scholarly journals Development and evaluation of ofloxacin orally disintegrating tablets

2012 ◽  
Vol 48 (2) ◽  
pp. 217-225 ◽  
Author(s):  
Badrinath Pralhadrao Mohite ◽  
Sandip Annaji Chafle ◽  
Jayaprakash Somasundaram ◽  
Jasmine Gev Avari
Keyword(s):  
Bitter Taste ◽  
Drug Loading ◽  
Masking Effect ◽  
Taste Masking ◽  
Physical Parameters ◽  
Effect Of Ph ◽  
Orally Disintegrating Tablets ◽  
Cation Exchange Resins ◽  
Weak Cation Exchange ◽  
Exchange Resins

Bitter taste of ofloxacin, a broad spectrum bactericidal agent, is masked and orally disintegrating tablets were formulated. The bitter taste is masked by forming complex between drug and weak cation exchange resins, Tulsion 335 and Indion 204. Effect of pH and drug:resin ratio on the drug loading was studied. Maximum drug loading was observed at pH 6. Ratio of 1:2 of drug:resin masked almost complete bitterness of ofloxacin. Formation of complexes was confirmed by IR spectroscopy. Physical characterization of taste masked complexes was carried out. Present work envisages the taste masking of ofloxacin and development of orally disintegrating tablets. The effect of pH and resin quantities on drug loading were studied to find the optimum conditions of drug loading for complete taste masking. Effect of superdisintegrants like sodium starch glycolate, croscarmellose sodium and polyplasdone XL at varying level on physical parameters of compressed tablets was also assessed. The formulations containing 5 % w/w polyplasdone XL showed about 90 % of drug release within 5 minutes. No significant differences were observed in the physical parameters of resinates as well as tablets prepared from Tulsion 335 and Indion 204.

Formulation and Evaluation of Baclofen Orally Disintegrating Tablets

1970 ◽  
Vol 2 (4) ◽  
pp. 733-738
Author(s):  
Dumpeti Janardhan ◽  
Joginapally Sreekanth ◽  
P.Theja Pavan Kumar ◽  
M.Vamshi Krishna
Keyword(s):  
Pilot Scale ◽  
Taste Masking ◽  
Wet Granulation ◽  
Physical Parameters ◽  
Disintegration Time ◽  
Granulation Process ◽  
Good Taste ◽  
Orally Disintegrating Tablets ◽  
Human Volunteers ◽  
Eudragit Epo

The purpose of this study was to evaluate the potential of polymers for masking the taste of bitter drugs when incorporated into orally disintegrating tablets. The tablets were produced by simple wet granulation technique with a model compound (baclofen) which is moderately bitter. The formulating procedure had two variables to obtain good taste masking with desirable characteristics. The optimal granulation process parameters were polymer selection and its concentration (w/w), suitable for pilot scale level. Dextrates, β- cyclodextrin, eudragit EPO and PVP K-30 were used in preparation of granules by using water and iso-propyl alcohol. Crospovidone was used intra and extra granularly as superdisintegrant.  Sodium bicarbonate and citric acid were used as effervescent for fast disintegration of tablets, which also optionally act as desensitizer of taste buds. Results from evaluation of tablets indicated a disintegration time (avg) of 30-35 sec and 100% drug release was achieved within 5 min. But taste masking was achieved by only with eudragit EPO. Results from an evaluation by a panel of six human volunteers demonstrated that the orally disintegrating tablets which are prepared by using polymer Eudragit EPO (5% and 7.5% w/w of tablet) and PVP (7.5% w/w of tablet) improved taste, significantly. On studying physical parameters, F9 formulation demonstrated acceptable level of hardness and friability with good taste masking and it was thus considered as an optimized formulation

Double-coated enrofloxacin microparticles with chitosan and alginate: Preparation, characterization and taste-masking effect study

2017 ◽  
Vol 170 ◽  
pp. 247-253 ◽  
Author(s):  
Mengxi Liu ◽  
Daiping Yin ◽  
Hualin Fu ◽  
Fengying Deng ◽  
Guangneng Peng ◽  
...  
Keyword(s):  
Effect Study ◽  
Masking Effect ◽  
Taste Masking

scholarly journals PREPARATION AND EVALUATION OF ORALLY DISINTEGRATING TABLETS OF DROTAVERINE HYDROCHLORIDE USING SUBLIMATION TECHNIQUE

2018 ◽  
Vol 10 (5) ◽  
pp. 85
Author(s):  
Kuralla Hari ◽  
Saripilli Rajeswari ◽  
Kolapalli Venkata Ramanamurthy
Keyword(s):  
Differential Scanning Calorimetry ◽  
Infrared Spectroscopy ◽  
Fourier Transformation ◽  
Taste Masking ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Orally Disintegrating Tablets ◽  
Fourier Transformation Infrared Spectroscopy ◽  
Drotaverine Hydrochloride ◽  
Sublimation Technique

Objective: To formulate orally disintegrating taste masked tablets of drotaverine hydrochloride (HCl) by sublimation technique.Methods: Initially superdisintegrant was selected and its concentration was optimized by pre-compression and post-compression parametric evaluation. Camphor and menthol were used as sublimating agents alone and in combination to mask the taste of drotaverine hydrochloride. Prepared tablets were evaluated for physicochemical evaluation, in vitro dissolution studies and fourier transformation-infrared spectroscopy, differential scanning calorimetry and X-ray diffractometry studies.Results: The optimised formulation DCM2 prepared with a mixture of camphor and menthol was characterised by fourier transformation-infrared spectroscopy, differential scanning calorimetry and X-ray diffractometry studies and found no incompatibility and no major shifts were noticed.Conclusion: The results demonstrated that the prepared drotaverine HCl orally disintegrating tablets showed better taste masking. The present sublimation technique can be effectively used for taste masking and also for orally disintegrating tablets.

scholarly journals EXPLORING THE TASTE MASKING EFFECT OF ION EXCHANGE RESINS IN ORODISPERSIBLE TABLETS OF LEVOCETIRIZINE HYDROCHLORIDE

2019 ◽  
Vol 10 (1) ◽  
pp. 161-166
Author(s):  
K Sampath Kumar ◽  
M Ravindra Babu ◽  
A B Sravani ◽  
D Maheswara Reddy ◽  
V Vijay Kumar
Keyword(s):  
Ion Exchange ◽  
Masking Effect ◽  
Taste Masking ◽  
Ion Exchange Resins ◽  
Orodispersible Tablets ◽  
Exchange Resins

scholarly journals Rendering Strategy to Counter Mutual Masking Effect in Multiple Tactile Feedback

2020 ◽  
Vol 10 (14) ◽  
pp. 4990
Author(s):  
Semin Ryu ◽  
Dongbum Pyo ◽  
Soo-Chul Lim ◽  
Dong-Soo Kwon
Keyword(s):  
Stimulus Intensity ◽  
Mechanical Vibration ◽  
Recognition Rate ◽  
Tactile Feedback ◽  
Virtual Object ◽  
Masking Effect ◽  
Sensation Level ◽  
User Test ◽  
Combined Use ◽  
Masking Function

Recently, methods and devices that simultaneously utilize two or more tactile feedback types have been proposed for more immersive interaction with virtual objects. However, the masking effect, which makes us less sensitive to various stimuli presented at the same time, has scarcely been explored. In this study, we propose a novel tactile rendering algorithm that can eliminate the mutual masking effect at the user’s sensation level, when mechanical vibration and electrovibration are applied simultaneously. First, the masking functions of the two stimuli were investigated for various stimulus combinations. Based on these, a generalized form of the masking function was derived. We then tested and confirmed that the proposed algorithm, which calculates the required stimulus intensity to compensate for the mutual masking effect, could render the arbitrary stimulus intensity desired to be perceived by the users. The results of the user test revealed that the proposed rendering algorithm significantly improved the virtual object recognition rate by approximately 23% when geometry and texture were presented jointly. This finding suggests principal guidelines for the combined use of mechanical vibration and electrovibration, as well as for other combinations of different tactile feedback types.

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