scholarly journals Agglomeration Behaviour and Modification of Spherical Crystallization Process of Pharmaceuticals by the Emulsion-Solvent-Diffusion Method and Proposed Closed-Circuit Batch System

1991 ◽  
Vol 111 (8) ◽  
pp. 451-462 ◽  
Author(s):  
Yoshiaki KAWASHIMA ◽  
Cui FUDE ◽  
Hirofumi TAKEUCHI ◽  
Toshiyuki NIWA ◽  
Tomoaki HINO ◽  
...  
Keyword(s):  
Crystallization Process ◽  
Closed Circuit ◽  
Diffusion Method ◽  
Solvent Diffusion ◽  
Batch System ◽  
Spherical Crystallization ◽  
Emulsion Solvent Diffusion Method

scholarly journals PREPARATION, CHARACTERIZATION AND EVALUATION OF POLY (LACTIDE –CO –GLYCOLIDE) MICROSPHERES FOR THE CONTROLLED RELEASE OF ZIDOVUDINE

2017 ◽  
Vol 9 (12) ◽  
pp. 70 ◽  
Author(s):  
Seema Kohli ◽  
Abhisek Pal ◽  
Suchit Jain
Keyword(s):  
Particle Size ◽  
Controlled Release ◽  
Double Emulsion ◽  
Entrapment Efficiency ◽  
Diffusion Method ◽  
Average Particle ◽  
Plga Microspheres ◽  
Good Reproducibility ◽  
Solvent Diffusion ◽  
Emulsion Solvent Diffusion Method

Objective: The purpose of this research work was to develop and evaluate microspheres appropriate for controlled release of zidovudine (AZT).Methods: The AZT loaded polylactide-co-glycolide (PLGA) microspheres were prepared by W/O/O double emulsion solvent diffusion method. Compatibility of drug and polymer was studied by Fourier-transform infrared spectroscopy (FTIR). The influence of formulation factors (drug: polymer ratio, stirring speed, the concentration of surfactant) on particle size encapsulation efficiency and in vitro release characteristics of the microspheres was investigated. Release kinetics was studied and stability study was performed as per ICH guidelines.Results: Scanning electron microscopy (SEM) images show good reproducibility of microspheres from different batches. The average particle size was in the range of 216-306 μm. The drug-loaded microspheres showed 74.42±5.08% entrapment efficiency. The cumulative percentage released in phosphate Buffer solution (PBS) buffer was found to be 55.32±5.89 to 74.42±5.08 %. The highest regressions (0.981) were obtained for zero order kinetics followed by Higuchi (0.968) and first order (0.803).Conclusion: Microsphere prepared by double emulsion solvent diffusion method was investigated and the results revealed that 216-306 μm microsphere was successfully encapsulated in a polymer. FT-IR analysis, entrapment efficiency and SEM Studies revealed the good reproducibility from batch to batch. The microspheres were of an appropriate size and suitable for oral administration. Thus the current investigation show promising results of PLGA microspheres as a matrix for drug delivery and merit for In vivo studies for scale up the technology.

Genipin-cross-linked silk fibroin microspheres prepared by the simple water-in-oil emulsion solvent diffusion method

2010 ◽  
Vol 203 (3) ◽  
pp. 603-608 ◽  
Author(s):  
Thanonchat Imsombut ◽  
Yaowalak Srisuwan ◽  
Prasong Srihanam ◽  
Yodthong Baimark
Keyword(s):  
Silk Fibroin ◽  
Diffusion Method ◽  
Oil Emulsion ◽  
Solvent Diffusion ◽  
Water In Oil Emulsion ◽  
Emulsion Solvent Diffusion Method

Development of Agglomerated Crystals of Irbesartan by Spherical Crystallization Technique for Enhancing the Micromeritic and Solubility Property

1970 ◽  
Vol 9 (2) ◽  
pp. 3193-3207
Author(s):  
Kranthi Kumar Kotta ◽  
Pankaj Kumar Sharma ◽  
L. Srinivas
Keyword(s):  
Processing Parameters ◽  
Diffusion Method ◽  
Dimethyl Formamide ◽  
Compression Technique ◽  
Crystallization Method ◽  
Spherical Crystallization ◽  
Dispersible Tablets ◽  
Dissolution Efficiency ◽  
Spherical Crystals ◽  
Emulsion Solvent Diffusion Method

Irbesartan is practically insoluble in water. The aim of the present study is to increase the solubility of irbesartan by spherical crystallization method and formulate it into oral tablets. Three different solvents such as N, N dimethyl formamide, chloroform, and water were selected. Spherical crystals were prepared by using β-cyclodextrin andHP-β-cyclodextrin in various ratios by quasi emulsion solvent diffusion method. Spherical agglomerates are prepared and converted into oral dispersible tablets by direct compression technique. Various super disintegrating agents such as SSG, Croscarmalose and crospovidone F36 of 1:3 ratios were utilized and results suggest high dissolution efficiency of 98%. Analysis of variance showed a significance of p<0.05, which indicates the importance of co-processing parameters variability within the specified limits

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