scholarly journals Individual Data Meta-analysis Provides No Evidence Of Individual Response Variation For Individuals Supplementing With Beta-alanine

2021 ◽  
Vol 53 (8S) ◽  
pp. 282-282
Author(s):  
Gabriel Perri Esteves ◽  
Paul Swinton ◽  
Craig Sale ◽  
Ruth James ◽  
Guilherme Giannini Artioli ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Individual Response ◽  
Individual Data ◽  
Beta Alanine ◽  
Response Variation

scholarly journals Human Skeletal Muscle has Large Capacity to Increase Carnosine Content in Response to Beta-Alanine Supplementation. A Systematic Review with Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis

2019 ◽  
Author(s):  
Nathalia Saffioti Rezende ◽  
Paul Swinton ◽  
Luana Farias de Oliveira ◽  
Rafa Pires da Silva ◽  
Vinicius Eira da Silva ◽  
...  
Keyword(s):  
Systematic Review ◽  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Meta Analysis ◽  
Aggregate Data ◽  
Individual Data ◽  
Muscle Carnosine ◽  
Large Capacity ◽  
Beta Alanine ◽  
Emax Model

ABSTRACTBeta-alanine (BA) supplementation increases muscle carnosine content (MCarn), and is ergogenic in many situations. Currently, many questions on the nature of the Mcarn response to supplementation are open, and the response to these has considerable potential to enhance the efficacy and applications of this supplementation strategy.ObjectiveTo conduct a Bayesian analysis of available data on the Mcarn response to BA supplementation.MethodsA systematic review with meta-analysis of individual and published aggregate data using a dose response (Emax) model was conducted. The protocol was designed according to PRISMA guidelines. A three-step screening strategy was undertaken to identify studies that measured the Mcarn response to BA supplementation. In addition, individual data from 5 separate studies conducted in the authors’ laboratory were analysed. Data were extracted from all controlled and uncontrolled supplementation studies conducted on healthy humans. Meta-regression was used to consider the influence of potential moderators (including dose, sex, age, baseline Mcarn and analysis method used) on the primary outcome.Results and ConclusionThe Emax model indicated that human skeletal muscle has large capacity for non-linear Mcarn accumulation, and that commonly used BA supplementation protocols may not come close to saturating muscle carnosine content. Neither baseline values, nor sex, appear to influence subsequent response to supplementation. Analysis of individual data indicated that Mcarn is relatively stable in the absence of intervention, and effectually all participants respond to BA supplementation (99.3% response [95%CrI: 96.2 – 100]).

scholarly journals Individual Participant Data Meta-Analysis Provides No Evidence of Intervention Response Variation in Individuals Supplementing With Beta-Alanine

2021 ◽  
pp. 1-9
Author(s):  
Gabriel Perri Esteves ◽  
Paul Swinton ◽  
Craig Sale ◽  
Ruth M. James ◽  
Guilherme Giannini Artioli ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Change Score ◽  
External Factors ◽  
Time To Exhaustion ◽  
Individual Participant Data ◽  
Muscle Carnosine ◽  
Change Scores ◽  
Beta Alanine ◽  
Individual Participant ◽  
Response Variation

Currently, little is known about the extent of interindividual variability in response to beta-alanine (BA) supplementation, nor what proportion of said variability can be attributed to external factors or to the intervention itself (intervention response). To investigate this, individual participant data on the effect of BA supplementation on a high-intensity cycling capacity test (CCT110%) were meta-analyzed. Changes in time to exhaustion (TTE) and muscle carnosine were the primary and secondary outcomes. Multilevel distributional Bayesian models were used to estimate the mean and SD of BA and placebo group change scores. The relative sizes of group SDs were used to infer whether observed variation in change scores were due to intervention or non-intervention-related effects. Six eligible studies were identified, and individual data were obtained from four of these. Analyses showed a group effect of BA supplementation on TTE (7.7, 95% credible interval [CrI] [1.3, 14.3] s) and muscle carnosine (18.1, 95% CrI [14.5, 21.9] mmol/kg DM). A large intervention response variation was identified for muscle carnosine (σIR = 5.8, 95% CrI [4.2, 7.4] mmol/kg DM) while equivalent change score SDs were shown for TTE in both the placebo (16.1, 95% CrI [13.0, 21.3] s) and BA (15.9, 95% CrI [13.0, 20.0] s) conditions, with the probability that SD was greater in placebo being 0.64. In conclusion, the similarity in observed change score SDs between groups for TTE indicates the source of variation is common to both groups, and therefore unrelated to the supplement itself, likely originating instead from external factors such as nutritional intake, sleep patterns, or training status.

scholarly journals Indicators of response to exercise training: a systematic review and meta-analysis

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e044676
Author(s):  
Arash Ardavani ◽  
Hariz Aziz ◽  
Bethan E Phillips ◽  
Brett Doleman ◽  
Imran Ramzan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Exercise Training ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Response Rates ◽  
Whole Body ◽  
Individual Response ◽  
Qualitative Synthesis ◽  
Exercise Response ◽  
High Intensity Interval

BackgroundMeans-based analysis of maximal rate of oxygen consumption (VO2max) has traditionally been used as the exercise response indicator to assess the efficacy of endurance (END), high intensity interval (HIIT) and resistance exercise training (RET) for improving cardiorespiratory fitness and whole-body health. However, considerable heterogeneity exists in the interindividual variability response to the same or different training modalities.ObjectivesWe performed a systematic review and meta-analysis to investigate exercise response rates in the context of VO2max: (1) in each training modality (END, HIIT and RET) versus controls, (2) in END versus either HIIT or RET and (3) exercise response rates as measured by VO2max versus other indicators of positive exercise response in each exercise modality.MethodsThree databases (EMBASE, MEDLINE, CENTRAL) and additional sources were searched. Both individual response rate and population average data were incorporated through continuous data, respectively. Of 3268 identified manuscripts, a total of 29 studies were suitable for qualitative synthesis and a further 22 for quantitative. Stratification based on intervention duration (less than 12 weeks; more than or equal to 12 weeks) was undertaken.ResultsA total of 62 data points were procured. Both END and HIIT training exhibited differential improvements in VO2max based on intervention duration. VO2max did not adequately differentiate between END and HIIT, irrespective of intervention length. Although none of the other exercise response indicators achieved statistical significance, LT and HRrest demonstrated common trajectories in pooled and separate analyses between modalities. RET data were highly limited. Heterogeneity was ubiquitous across all analyses.ConclusionsThe potential for LT and HRrest as indicators of exercise response requires further elucidation, in addition to the exploration of interventional and intrinsic sources of heterogeneity.

scholarly journals Correction to: Epinephrine and short-term survival in cardiogenic shock: an individual data meta-analysis of 2583 patients

2018 ◽  
Vol 44 (11) ◽  
pp. 2022-2023 ◽  
Author(s):  
Valentine Léopold ◽  
Etienne Gayat ◽  
Romain Pirracchio ◽  
Jindrich Spinar ◽  
Jiri Parenica ◽  
...  
Keyword(s):  
Cardiogenic Shock ◽  
Meta Analysis ◽  
Individual Data ◽  
Short Term ◽  
Term Survival ◽  
Short Term Survival

scholarly journals Individual response to antidepressants for depression in adults-a meta-analysis and simulation study

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0237950 ◽  
Author(s):  
Klaus Munkholm ◽  
Stephanie Winkelbeiner ◽  
Philipp Homan
Keyword(s):  
Simulation Study ◽  
Meta Analysis ◽  
Individual Response
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