scholarly journals Theoretical and experimental analysis of ototoxic mechanism in the spiral ligament fibrocytes by multi-level simulation with ion transports in the cochlea

2016 ◽  
Vol 147 (2) ◽  
pp. 80-83
Author(s):  
Fumiaki Nin ◽  
Takamasa Yoshida ◽  
Shingo Murakami ◽  
Satoru Uetsuka ◽  
Genki Ogata ◽  
...  
Keyword(s):  
Experimental Analysis ◽  
Spiral Ligament ◽  
Multi Level ◽  
Spiral Ligament Fibrocytes

A voltage- and Ca2+-dependent big conductance K channel in cochlear spiral ligament fibrocytes

2003 ◽  
Vol 445 (6) ◽  
pp. 683-692 ◽  
Author(s):  
F. Liang ◽  
A. Niedzielski ◽  
B. A. Schulte ◽  
S. S. Spicer ◽  
D. J. Hazen-Martin ◽  
...  
Keyword(s):  
K Channel ◽  
Spiral Ligament ◽  
Spiral Ligament Fibrocytes

Spiral ligament fibrocytes release chemokines in response to otitis media pathogens

2006 ◽  
Vol 126 (6) ◽  
pp. 564-569 ◽  
Author(s):  
Sung-Kyun Moon ◽  
Sung-Kyun Moon ◽  
Raekil Park ◽  
Sung-Kyun Moon ◽  
Raekil Park ◽  
...  
Keyword(s):  
Otitis Media ◽  
Spiral Ligament ◽  
Spiral Ligament Fibrocytes

Immunolocalization of aquaporin CHIP in the guinea pig inner ear

1995 ◽  
Vol 269 (6) ◽  
pp. C1450-C1456 ◽  
Author(s):  
K. M. Stankovic ◽  
J. C. Adams ◽  
D. Brown
Keyword(s):  
Inner Ear ◽  
Basilar Membrane ◽  
Polyclonal Antibodies ◽  
Close Association ◽  
Water Channel ◽  
Normal Function ◽  
Oval Window ◽  
Spiral Ligament ◽  
Bony Labyrinth ◽  
Spiral Ligament Fibrocytes

Aquaporin CHIP (AQP-CHIP) is a water channel protein previously identified in red blood cells and water transporting epithelia. The inner ear is an organ of hearing and balance whose normal function depends critically on maintenance of fluid homeostasis. In this study, AQP-CHIP, or a close homologue, was found in specific cells of the inner ear, as assessed by immunocytochemistry with the use of affinity-purified polyclonal antibodies against AQP-CHIP.AQP-CHIP was predominantly found in fibrocytes in close association with bone, including most of the cells lining the bony labyrinth and in fibrocytes lining the endolymphatic duct and sac. AQP-CHIP-positive cells not directly apposing bone include cells under the basilar membrane, some type III fibrocytes of the spiral ligament, fibrocytes of the spiral limbus, and the trabecular perilymphatic tissue extending from the membranous to the bony labyrinth. AQP-CHIP was also found in the periosteum of the middle ear and cranial bones, as well as in chondrocytes of the oval window and stapes. The distribution of AQP-CHIP in the inner ear suggests that AQP-CHIP may have special significance for maintenance of bone and the basilar membrane, and for function of the spiral ligament.

Significance of spiral ligament fibrocytes with cochlear inflammation

2000 ◽  
Vol 56 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Issei Ichimiya ◽  
Kazuhide Yoshida ◽  
Takashi Hirano ◽  
Masashi Suzuki ◽  
Goro Mogi
Keyword(s):  
Spiral Ligament ◽  
Cochlear Inflammation ◽  
Spiral Ligament Fibrocytes

Developmental changes in cochlear spiral ligament fibrocytes of rat inner ear

2007 ◽  
Vol 58 ◽  
pp. S157
Author(s):  
Reiko Nagashima ◽  
Hideki Mutai ◽  
Tatsuo Matsunaga ◽  
Kiyokazu Ogita
Keyword(s):  
Inner Ear ◽  
Developmental Changes ◽  
Spiral Ligament ◽  
Spiral Ligament Fibrocytes
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