scholarly journals Anticonvulsant activity of clonazepam in experimental animals

1976 ◽  
Vol 72 (7) ◽  
pp. 763-794 ◽  
Author(s):  
Takashi YAJIMA ◽  
Katsuko URITANI ◽  
Rie AOKI ◽  
Tsutomu SUZUKI ◽  
Keiji NAKAMURA
Keyword(s):  
Anticonvulsant Activity ◽  
Experimental Animals

scholarly journals Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission

2009 ◽  
Vol 15 (4) ◽  
pp. 165-168 ◽  
Author(s):  
Lucindo J. Quintans-Júnior ◽  
Davi A. Silva ◽  
Jullyana S. Siqueira ◽  
Adriano A.S. Araújo ◽  
Adriana G. Guimarães ◽  
...  
Keyword(s):  
Anticonvulsant Activity ◽  
Receptor Complex ◽  
Gabaergic Neurotransmission ◽  
Gaba A ◽  
Experimental Animals ◽  
Anticonvulsant Property

AIM: In the present study we verified the anticonvulsant properties of the new tryptamine analogue, N-salicyloyltryptamine (NST), in rodents. METHODS AND RESULTS: In the evaluation of the anticonvulsant activity, NST protected the animals from the incidence of seizures induced by pentylenetetrazole (PTZ) and picrotoxin (PIC), in doses of 100 and 200 mg/kg. NST (100 and 200 mg/kg, i.p.) significantly eliminated the extensor reflex of maximal electric-induced seizure tests in 40% of the experimental animals. However, in the PTZ model FLU (10 mg/kg, i.p.), an antagonist of the benzodiazepine (BZD) site in the GABA A-BZD receptor complex, inhibited the prolongation of seizure latency induced by NST. CONCLUSION: Our results demonstrated an anticonvulsant activity of the new analogue that could be, at least in part, associated to the involvement of the GABAergic mechanism.

scholarly journals Evaluation of the Anticonvulsant Activity of the Hydroethanolic Extract of Crinum scillifolium Bulbs (Amaryllidaceae) in Experimental Animals

2017 ◽  
Vol 5 (2) ◽  
pp. 25-30
Author(s):  
Koua Kadio Brou Donald ◽  
Kouakou Sylvain Landry ◽  
Yapo Adou Francis ◽  
Yapi Houphouet Felix ◽  
N'tamon Amon Diane Marina ◽  
...  
Keyword(s):  
Anticonvulsant Activity ◽  
Experimental Animals ◽  
Hydroethanolic Extract

scholarly journals Evaluation of the Anticonvulsant Activity of the Aqueous Extract of Crinum Scillifolium Bulbs (Amaryllidaceae) In Experimental Animals

2017 ◽  
Vol 12 (03) ◽  
pp. 35-39
Author(s):  
Koua Kadio Brou Donald ◽  
N’Tamon Amon Diane Marina ◽  
Okpekon Aboua Timothée ◽  
Kouakou Sylvain Landry ◽  
Yapi Houphouet Felix
Keyword(s):  
Aqueous Extract ◽  
Anticonvulsant Activity ◽  
Experimental Animals

Effects of amlodipine, diltiazem, and verapamil on the anticonvulsant action of topiramate against maximal electroshock-induced seizures in micePresented in part at the 11th Congress of the European Federation of Neurological Societies, Brussels, Belgium, 25–28 August 2007.

2008 ◽  
Vol 86 (3) ◽  
pp. 113-121 ◽  
Author(s):  
Jarogniew J. Luszczki ◽  
Michal K. Trojnar ◽  
Marcin P. Trojnar ◽  
Zaneta Kimber-Trojnar ◽  
Beata Szostakiewicz ◽  
...  
Keyword(s):  
Anticonvulsant Activity ◽  
European Federation ◽  
Maximal Electroshock ◽  
Calcium Channel Antagonists ◽  
Maximal Electroshock Seizure ◽  
Experimental Animals ◽  
Anticonvulsant Action ◽  
Mes Test ◽  
Total Brain ◽  
New Generation

To assess the effect of 3 calcium channel antagonists (amlodipine, diltiazem, and verapamil) on the anticonvulsant action of topiramate (a new generation antiepileptic drug) in the mouse maximal electroshock seizure (MES) model. Amlodipine (20 mg/kg) significantly enhanced the anticonvulsant activity of topiramate in the MES test in mice, reducing its ED50 value from 54.83 to 33.10 mg/kg (p < 0.05). Similarly, diltiazem (5 and 10 mg/kg) markedly potentiated the antiseizure action of topiramate against MES, lowering its ED50 value from 54.83 to 32.48 mg/kg (p < 0.05) and 28.68 mg/kg (p < 0.01), respectively. In contrast, lower doses of amlodipine (5 and 10 mg/kg) and diltiazem (2.5 mg/kg) and all doses of verapamil (5, 10, and 20 mg/kg) had no significant impact on the antiseizure action of topiramate. Pharmacokinetic verification of the interaction of topiramate with amlodipine and diltiazem revealed that neither amlodipine nor diltiazem affected total brain topiramate concentration in experimental animals, and thus, the observed interactions were concluded to be pharmacodynamic in nature. The favorable combinations of topiramate with amlodipine or diltiazem deserve more attention from a clinical viewpoint because the enhanced antiseizure action of topiramate was not associated with any pharmacokinetic changes in total brain topiramate concentration.

scholarly journals Anticonvulsant activity of the fractionated extract of Crinum jagus bulbs in experimental animals

2012 ◽  
Vol 2 ◽  
pp. S446-S452 ◽  
Author(s):  
CCA Azikiwe ◽  
IM Siminialayi ◽  
N Brambaifa ◽  
LU Amazu ◽  
JC Enye ◽  
...  
Keyword(s):  
Anticonvulsant Activity ◽  
Experimental Animals

Analytical Electron Microscopy (AEM) of Meningeal Cells Exposed to Particulate Cobalt During Studies of Experimental Epilepsy

1982 ◽  
Vol 40 ◽  
pp. 186-187
Author(s):  
R.G. Frederickson ◽  
R.G. Ulrich ◽  
J.L. Culberson
Keyword(s):  
Electron Microscopy ◽  
Analytical Electron Microscopy ◽  
Experimental Epilepsy ◽  
Metallic Cobalt ◽  
Experimental Animals ◽  
X Ray ◽  
Brain Surface ◽  
Meningeal Cells ◽  
Analytical Electron ◽  
The Brain

Metallic cobalt acts as an epileptogenic agent when placed on the brain surface of some experimental animals. The mechanism by which this substance produces abnormal neuronal discharge is unknown. One potentially useful approach to this problem is to study the cellular and extracellular distribution of elemental cobalt in the meninges and adjacent cerebral cortex. Since it is possible to demonstrate the morphological localization and distribution of heavy metals, such as cobalt, by correlative x-ray analysis and electron microscopy (i.e., by AEM), we are using AEM to locate and identify elemental cobalt in phagocytic meningeal cells of young 80-day postnatal opossums following a subdural injection of cobalt particles.

Ultrastructure and analytical microprobe analysis of simian lung mite pigments

1986 ◽  
Vol 44 ◽  
pp. 324-325
Author(s):  
R. W. Cole ◽  
J. C. Kim
Keyword(s):  
Biomedical Research ◽  
Tissue Damage ◽  
Microprobe Analysis ◽  
Old World Monkeys ◽  
Old World ◽  
Experimental Animals ◽  
The Past ◽  
Lung Mite ◽  
Mite Infestations ◽  
Cardiopulmonary System

In recent years, non-human primates have become indispensable as experimental animals in many fields of biomedical research. Pharmaceutical and related industries alone use about 2000,000 primates a year. Respiratory mite infestations in lungs of old world monkeys are of particular concern because the resulting tissue damage can directly effect experimental results, especially in those studies involving the cardiopulmonary system. There has been increasing documentation of primate parasitology in the past twenty years.

The Effect of ACTH on Gastric Secretion in Experimental Animals

1952 ◽  
Vol 21 (2) ◽  
pp. 276-279 ◽  
Author(s):  
Jose M. Zubiran ◽  
Allan E. Kark ◽  
Lester R. Dragstedt
Keyword(s):  
Gastric Secretion ◽  
Experimental Animals
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