Mass Spectrometry of Metal Complexes of Bis-Quinolizidine Alkaloids: Electron Ionization and Fast Atom Bombardment Mass Spectral Study of Copper(II) (–)-Sparteine and (–)-α-Isosparteine Complexes

2009 ◽  
Vol 15 (4) ◽  
pp. 487-495 ◽  
Author(s):  
Beata Jasiewicz ◽  
Elżbieta Wyrzykiewicz
Keyword(s):  
Fast Atom Bombardment ◽  
Electron Ionization ◽  
Collision Induced Dissociation ◽  
Quinolizidine Alkaloids ◽  
Spectral Measurements ◽  
Mass Measurements ◽  
Mass Spectral ◽  
Accurate Mass Measurements ◽  
Mass Spectral Study ◽  
Comparison Of The Results

The electron ionization (EI) and fast atom bombardment (FAB) mass spectral fragmentations of ten copper(II) dichloride (dibromide, diformate, diacetate and dithiocyanate) complexes of (–)-sparteine and (–)-α-isosparteine were investigated. Fragmentation pathways, elucidation of which was assisted by accurate mass measurements and metastable transitions (EI-MS), as well as FAB/collision-induced dissociation (CID) mass spectral measurements are discussed. The data obtained create the basis for the differentiation of the ligand (sparteine or α-isosparteine) in the investigated complexes. The comparison of the results with those obtained previously for corresponding zinc(II) complexes forms the basis for the differentiation of metals in these compounds. The results show that both EI-MS and FAB-MS are very useful tools for the differentiation of ligands, as well as metals in the series of Zn(II) and Cu(II) dichloride (dibromide, diacetate, diformate, dithioacetate) complexes of (–)-sparteine and (–)-α-isosparteine.

Differentiation of the Isomeric o-(m- and p-) Nitro-(Chloro- and Bromo-)Benzyl-2,4-(and 2,1-) Disubstituted 2-Thiocytosinium Halides by Electron Impact Ionisation and Fast Atom Bombardment Mass Spectrometry

2009 ◽  
Vol 15 (4) ◽  
pp. 497-506 ◽  
Author(s):  
Tomasz Pospieszny ◽  
Elżbieta Wyrzykiewicz
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectra ◽  
Fast Atom Bombardment ◽  
Collision Induced Dissociation ◽  
Mass Measurements ◽  
Fragmentation Pathways ◽  
Mass Spectral ◽  
Fragment Ions ◽  
Accurate Mass Measurements ◽  
Impact Ionisation

Electron ionisation (EI) and fast atom bombardment (FAB) mass spectral fragmentations of nine 2,4-(and 2,1-) disubstituted o-( m- and p-)nitro-(chloro- and bromo-)-2-thiocytosinium halides are investigated. Fragmentation pathways, whose elucidation is assisted by accurate mass measurements and metastable transitions [EI-mass spectrometry (MS)], as well as FAB/collision-induced dissociation (CID) mass spectra measurements are discussed. The correlations between the abundances of the (C11H10N4SO2)+1–3; (C11H10N3SCl)+4–6 and (C11H10N3SBr)+7–9 ions and the selected fragment ions (EI-MS), as well as (C18H16N5SO4)+1–3; (C18H16N3SCl2)+4–6 and (C18H16N3SBr2) + 7–9 ions and the selected ions (C7H6NO2)+1–3; (C7H6Cl)+ 4–6; (C7H6Br)+ 7–9 (FAB-MS) are discussed. The data obtained can be used for distinguishing isomers.

Fast atom bombardment mass spectral study of tetracycline antibiotics

1993 ◽  
Vol 28 (12) ◽  
pp. 1512-1515 ◽  
Author(s):  
Ken-Ichi Harada ◽  
Katsuyoshi Masuda ◽  
Makoto Suzuki ◽  
Hisao Oka ◽  
Yoshitomo Ikai ◽  
...  
Keyword(s):  
Spectral Study ◽  
Fast Atom Bombardment ◽  
Tetracycline Antibiotics ◽  
Mass Spectral ◽  
Mass Spectral Study

Mass spectral studies of some desaurins and related 3,5-bismethylene-1,2,4-trithiolanes

1968 ◽  
Vol 46 (3) ◽  
pp. 365-375 ◽  
Author(s):  
Peter Yates ◽  
Thomas R. Lynch ◽  
L. S. Weiler
Keyword(s):  
Carbonyl Group ◽  
Mass Spectra ◽  
Molecular Ions ◽  
Spectral Studies ◽  
Mass Measurements ◽  
Metastable Peak ◽  
Fragmentation Pathways ◽  
Mass Spectral ◽  
Accurate Mass Measurements ◽  
Doubly Charged

The mass spectra of three desaurins and four related 3,5-bismethylene-1,2,4-trithiolanes have been interpreted with the aid of metastable peak assignments and accurate mass measurements. Strong molecular ion peaks are observed in the case of the aryl desaurins but not in that of their trithiolane counterparts. A variety of fragmentation pathways are postulated for the molecular ions, including cleavage on either side of a carbonyl group and elimination of a molecule of acylthioketene. In the case of the desaurins the latter process results in the formation of acylthioketene molecular ions, which could be distinguished from the doubly charged desaurin molecular ions. In the case of two of the trithiolanes, it is proposed that the ions resulting from loss of acylthioketene from the molecular ions undergo a novel type of McLafferty rearrangement and loss of carbon suboxysulfide to give aryl mercaptan molecular ions.

scholarly journals Advanced Analytical Approaches for the Analysis of Polyphenols in Plants Matrices—A Review

Separations ◽  
2021 ◽  
Vol 8 (5) ◽  
pp. 65
Author(s):  
Elena Roxana Chiriac ◽  
Carmen Lidia Chiţescu ◽  
Elisabeta-Irina Geană ◽  
Cerasela Elena Gird ◽  
Radu Petre Socoteanu ◽  
...  
Keyword(s):  
High Resolution Mass Spectrometry ◽  
Mode Selection ◽  
Analytical Techniques ◽  
Bioactive Metabolites ◽  
Mass Measurements ◽  
Mass Spectral ◽  
Chemical Profiling ◽  
Accurate Mass Measurements ◽  
Analytical Approaches ◽  
Identification And Characterization

Phenolic compounds are plants’ bioactive metabolites that have been studied for their ability to confer extensive benefits to human health. As currently there is an increased interest in natural compounds identification and characterization, new analytical methods based on advanced technologies have been developed. This paper summarizes current advances in the state of the art for polyphenols identification and quantification. Analytical techniques ranging from high-pressure liquid chromatography to hyphenated spectrometric methods are discussed. The topic of high-resolution mass spectrometry, from targeted quantification to untargeted comprehensive chemical profiling, is particularly addressed. Structure elucidation is one of the important steps for natural products research. Mass spectral data handling approaches, including acquisition mode selection, accurate mass measurements, elemental composition, mass spectral library search algorithms and structure confirmation through mass fragmentation pathways, are discussed.

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