Negative pathology following endoscopic resection of T1a squamous carcinoma of the glottis

2005 ◽  
Vol 119 (8) ◽  
pp. 592-594 ◽  
Author(s):  
R Nassif ◽  
S Loughran ◽  
C Moyes ◽  
K MacKenzie
Keyword(s):  
Endoscopic Resection ◽  
External Beam Radiotherapy ◽  
Squamous Carcinoma ◽  
Invasive Disease ◽  
Glottic Cancer ◽  
Resected Specimen ◽  
Squamous Cancer ◽  
Initial Biopsy ◽  
Laser Excision ◽  
Disease Free

Endoscopic CO2 laser excision for T1a glottic cancer is a recognized treatment modality producing equivalent disease-free and voice results to external beam radiotherapy. On reviewing a series of 15 patients who had undergone endoscopic resection of a T1a glottic squamous cancer, it was noted that five patients had negative excisional pathology following the initial biopsy of an invasive squamous carcinoma. The histopathology of each patient’s resected specimen was reviewed by a second pathologist who confirmed the accuracy of the results in all cases. We conclude that a significant number of early squamous carcinomas of the glottis present with very small localized, minimally invasive disease and that a proportion may be treated by biopsy alone.

The Endoscopic Management of Early Squamous Carcinoma of the Vocal Cord with the Carbon Dioxide Surgical Laser: Clinical Experience and a Proposed Subclassification

1986 ◽  
Vol 95 (5) ◽  
pp. 531-537 ◽  
Author(s):  
James A. Koufman
Keyword(s):  
Vocal Cord ◽  
Anterior Commissure ◽  
Squamous Carcinoma ◽  
Invasive Disease ◽  
Endoscopic Management ◽  
Vocal Process ◽  
Small Series ◽  
Endoscopic Laser ◽  
Excellent Method ◽  
Laser Excision

Sixteen patients with T1 vocal cord squamous cell carcinoma were treated with endoscopic laser excision during a 4-year period. Laser excision was the initial treatment in 11 patients, and it was used to treat 5 patients who had recurrence after radiotherapy. Postoperatively, 13 (81%) of the 16 patients had normal voices. Two patients with persistent postoperative hoarseness had had anterior commissure lesions and previous radiotherapy; the other patient had a subtotal cordectomy. One patient developed a subsequent new lesion 27 months after the initial laser treatment; he was successfully managed with a second endoscopic laser excision. Involvement of the anterior commissure or involvement of the vocal process with minimally invasive disease proved not to be a contraindication to laser excision. The overall results in this small series suggest that laser excision of T1 vocal cord carcinoma is an excellent method of treatment.

VISCERAL SQUAMOUS CANCER IN CHILDREN

PEDIATRICS ◽  
1958 ◽  
Vol 21 (4) ◽  
pp. 573-581
Author(s):  
Condict Moore
Keyword(s):  
Squamous Carcinoma ◽  
Pharyngeal Region ◽  
Squamous Cancer ◽  
Methods Of Treatment ◽  
Cancer In Children ◽  
Carcinoma Of The Tongue

Cases of squamous carcinomas, excluding carcinoma of the skin, reported in children have been reviewed. The disease is a medical curiosity. Most squamous carcinomas in children have occurred in the mouth and pharyngeal region. There is no evidence that these squamous cancers do not respond to the same methods of treatment and to the same degree as do the squamous cancers in adults. A case is reported of a patient with squamous carcinoma of the tongue, treated by surgery, who is living and well nearly 2 years after therapy.

T1/T2 glottic cancer managed by external beam radiotherapy—The influence of beam energy on local control

1998 ◽  
Vol 42 (1) ◽  
pp. 328 ◽  
Author(s):  
Padraig R. Warde ◽  
Brian O'Sullivan ◽  
Tony Panzarella ◽  
David G. Payne ◽  
Fei-Fei Liu ◽  
...  
Keyword(s):  
Local Control ◽  
Beam Energy ◽  
External Beam Radiotherapy ◽  
Glottic Cancer ◽  
External Beam

Prospective Evaluation of Intrahepatic Microscopic Occult Tumor Foci in Patients with Numerous Colorectal Liver Metastases

2018 ◽  
Vol 36 (4) ◽  
pp. 340-347 ◽  
Author(s):  
Luca Vigano ◽  
Luca Di Tommaso ◽  
Antonio Mimmo ◽  
Mauro Sollai ◽  
Matteo Cimino ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Intraoperative Imaging ◽  
Median Number ◽  
Early Recurrence ◽  
Resected Specimen ◽  
Lesion Analysis ◽  
Healthy Liver ◽  
Disease Free

Background: Patients with numerous colorectal liver metastases (CLM) have high risk of early recurrence after liver resection (LR). The presence of intrahepatic occult microscopic metastases missed by imaging has been hypothesized, but it has never been assessed by pathology analyses. Methods: All patients with > 10 CLM who underwent LR between September 2015 and September 2016 were considered. A large sample of liver without evidence of disease (“healthy liver”) was taken from the resected specimen and sent to the pathologist. One mm-thick sections were analyzed. Any metastasis, undetected by preoperative and intraoperative imaging, but identified by the pathologist was classified as occult microscopic metastasis. Results: Ten patients were prospectively enrolled (median number of CLM n = 15). In a per-lesion analysis, the sensitivity of computed tomography and magnetic resonance imaging was 91 and 98% respectively. The pathology examination confirmed all the CLM. All patients had an adequate sample of “healthy liver” (median number of examined blocks per sample n = 14 [5–33]). No occult microscopic metastases were detected. After a median follow-up of 15 months, 5 patients were disease-free. Recurrence was hepatic and bilobar in all patients. Conclusions: Clinically relevant occult microscopic disease in patients with numerous CLM is excluded. These results support the indication to resection in such patients and exclude the need for de principe major hepatectomy to increase the completeness of surgery.

scholarly journals Locoregional disease control after external beam radiotherapy in 91 patients with differentiated thyroid carcinoma and pT4 tumor stage - a single institution experience

2018 ◽  
Vol 52 (4) ◽  
pp. 453-460 ◽  
Author(s):  
Nikola Besic ◽  
Marta Dremelj ◽  
Gasper Pilko
Keyword(s):  
Thyroid Carcinoma ◽  
Multimodal Treatment ◽  
External Beam Radiotherapy ◽  
Locally Advanced ◽  
Disease Free Survival ◽  
Differentiated Thyroid Carcinoma ◽  
Locoregional Control ◽  
External Beam ◽  
Regional Metastases ◽  
Disease Free

Abstract Background Locoregional recurrence is common in patients with locally advanced differentiated thyroid carcinoma (DTC). Our aim was to find out the rate of locoregional control of the disease after external beam radiotherapy (EBRT) of the neck and mediastinum in patients with DTC and pT4 tumor. Patients and methods Altogether 91 patients (47 males, 44 females, median age 61 years) with DTC had EBRT of the neck and mediastinum as part of the multimodal treatment of pT4 tumor (63 cases pT4a, 28 cases pT4b) from the year 1973 to 2015. Data on clinical factors, histopathology and recurrence were collected. Disease-free, disease-specific and overall survival was calculated. Results Median tumor size was 5 cm (range 1–30 cm). Out of 91 patients, 23 had distant and 38 regional metastases. A total or near-total thyroidectomy, lobectomy, subtotal thyroidectomy and lymph node dissection was performed in 70%, 14%, 2% and 30% of cases, respectively. Thirteen percent of patients were not treated with surgery. All patients had EBRT and 39 had chemotherapy. Radioiodine (RAI) ablation of thyroid remnant and RAI therapy was applied in 90% and 40% of cases, respectively. Recurrence was diagnosed in 29/64 patients without a persistent disease: locoregional and distant in 16 and 13 cases, respectively. Five-year and ten-year disease-free survival rate was 64% and 48%, respectively. Conclusions The majority of patients with DTC and pT4 tumors who were treated with EBRT of the neck and mediastinum region as part of multimodal treatment have long-lasting locoregional control of the disease.

scholarly journals Adding pertuzumab to adjuvant therapy for high-risk HER2-positive early breast cancer in APHINITY: a GRADE analysis

2020 ◽  
Vol 9 (6) ◽  
pp. 423-430 ◽  
Author(s):  
Alberto Zambelli ◽  
Giovanni Pappagallo ◽  
Paolo Marchetti
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Adjuvant Therapy ◽  
Early Breast Cancer ◽  
Disease Free Survival ◽  
Invasive Disease ◽  
Her2 Positive ◽  
Free Survival ◽  
Distant Relapse ◽  
Disease Free

Aim: Adding pertuzumab to standard trastuzumab-based adjuvant therapy significantly improved invasive disease-free survival (IDFS) in the APHINITY trial. However, the magnitude of benefit was marginal in the overall population. Methods: We used GRADE (Grading of Recommendations Assessment, Development and Evaluation) analysis on data from APHINITY to build summary-of-findings tables to evaluate the efficacy, safety and quality of evidence of predefined clinical outcomes for the addition of pertuzumab to trastuzumab-based adjuvant therapy in patients with high-risk HER2-positive early breast cancer. Results: Pertuzumab significantly improved 3-year, event-free, absolute benefit in disease-free survival, IDFS and distant relapse-free interval (DFRI) in patients with node-positive or hormone receptor-negative disease. The analysis provides strength of evidence supporting the addition of pertuzumab in this patient population.

Loop diathermy excision of the abnormal cervical transformation zone

1991 ◽  
Vol 1 (3) ◽  
pp. 105-111 ◽  
Author(s):  
J. B. Murdoch ◽  
R. N. Grimshaw ◽  
J. M. Monaghan
Keyword(s):  
Squamous Carcinoma ◽  
Invasive Disease ◽  
Punch Biopsy ◽  
Excision Biopsy ◽  
Transformation Zone ◽  
Major Morbidity ◽  
Abnormal Cervical Cytology ◽  
Local Destruction ◽  
Colposcopy Clinic

Six-hundred patients with abnormal cervical transformation zones were treated by loop diathermy excision. The patients were referred to the colposcopy clinic in the Regional Department of Gynaecological Oncology, Gateshead with abnormal cervical cytology. The indications for treatment, management and follow-up are presented. All patients were managed as out-patients under local anesthesia (71%) or as half-day inpatients under short general anesthesia (29%). Patients were treated with loop diathermy excision of visible lesions or with loop diathermy conization as required. Eradication of cervical intra-epithelial neoplasia (CIN) was achieved with one treatment in 95.5% of cases of CIN. The procedure is rapidly and easily performed. Major morbidity is rare. Only two patients required blood transfusion following treatment. Loop diathermy excision is ideally suited to a policy of combined diagnosis and treatment for these patients allowing efficient use of clinic time. The danger of inadvertant local destruction of early invasive disease is minimized. When preliminary colposcopically directed punch-biopsy histology was compared to definitive loop histology, CIN3 was detected in 27.4% of loops where the punch biopsies failed to show CIN and one case of CIN3 on punch biopsy was upgraded to invasive squamous carcinoma on loop biopsy. Loop excision biopsy therefore gives more complete histologic information than traditional punch biopsy. This technique is effective, efficient, economical and highly acceptable to both patient and practitioner. It is now the treatment of choice for management of the abnormal transformation zone in our practice.

Feasibility of endoscopic resection in superficial esophageal squamous carcinoma

2011 ◽  
Vol 73 (5) ◽  
pp. 881-889.e2 ◽  
Author(s):  
Ji Young Choi ◽  
Young Soo Park ◽  
Hwoon-Yong Jung ◽  
Ji Yong Ahn ◽  
Mi-Young Kim ◽  
...  
Keyword(s):  
Endoscopic Resection ◽  
Squamous Carcinoma ◽  
Esophageal Squamous Carcinoma

Breast cancer in older women.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1132-1132
Author(s):  
David B. Pearlstone ◽  
Tyler Stewart ◽  
Ashkan Afshari ◽  
Lyly Nguyen ◽  
Rosemary Garofalo
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Older Women ◽  
Older Patients ◽  
Locally Advanced ◽  
Tumor Grade ◽  
Invasive Disease ◽  
Node Positive ◽  
Disease Free

1132 Background: Recent guidelines recommend minimizing breast cancer screening for women over the age of 75. This study examines the presentation and outcome of older patients with breast cancer to determine if increasing screening among older patients may result in better outcomes. Methods: A prospective database at Hackensack University Medical Center was queried for all patients with breast cancer diagnosed between 1/1/2006 and 1/1/2011. Numerical values compared by Student’s t -test; categorical values by Fisher exact test. Median time to events determined by Kaplan-Meier; outcomes compared by log-rank test. Results: 2200 patients were identified (> 75 years, n=335, < 75 years, n=1865). Among the older cohort, mean age was 81 +/- 4 years (range: 75 – 101); mean tumor size was 2.3 +/- 0.1 cm (range: .1 – 12). Most tumors were invasive and localized (in-situ: 12.7%, localized: 57.3%, node positive: 24.0%, metastatic: 5.8%) and most commonly ductal histology (ductal: 77.0%; lobular: 16.6%, mixed:6.2%). Only 10.0% of patients with invasive disease and 29.2% with positive nodes received systemic therapy; 90.2% underwent surgical resection. Disease-free and overall 5 year survival was 54.9% and 62.9% (in-situ: 82.2%; localized: 67.1%; node positive: 57%; metastatic 22%). Older patients had larger tumors (2.30 +/- .11 v. 1.91 +/- .04 cm; p<0.001), more locally advanced (T4) disease (6.7% v. 1.7%, p<.001), more invasive disease (89% v. 84%, p<.01). Older patients had less positive family history (21.7% v. 37.3%, p<.0001). There was no difference between the groups in race, presentation with stage IV disease, tumor grade, lymphovascular invasion, histologic subtype, triple negativity, or nodal positivity. Overall and disease free five year survival were significantly worse for older patients (OS: 90.2% v. 63.9%, p< .0001; DFS: 80.9% v. 54.9%, p<.0001). Conclusions: Breast cancer among older women leads to worse outcomes compared to younger patients, regardless of histology, invasiveness of disease, hormonal status, nodal status or tumor grade. Older women present with more invasive disease, larger tumors and more locally advanced disease, despite having less family history. This implies that continued screening beyond age 75 may lead to less advanced presentation and better outcomes.

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