Cat scratch disease: a diagnostic conundrum

2009 ◽  
Vol 20 (8) ◽  
pp. 585-586 ◽  
Author(s):  
C Scott ◽  
A Azwa ◽  
C Cohen ◽  
M McIntyre ◽  
N Desmond
Keyword(s):  
Lymph Nodes ◽  
Causative Agent ◽  
Bartonella Henselae ◽  
Lymphogranuloma Venereum ◽  
Cat Scratch Disease ◽  
Inguinal Lymphadenopathy ◽  
Animal Exposure

We report the case of a patient who presented to a clinic for evaluation of inguinal lymphadenopathy. Histology of the lymph nodes revealed micoabscess formation suggesting infection with Lymphogranuloma venereum (LGV) or Bartonella henselae – the causative agent in cat scratch disease (CSD). The patient recalled no preceding animal exposure. Clinical and serological findings initially suggested early LGV but convalescent serology supported CSD. This serves as an important reminder that B. henselae infection should be considered a cause of regional lymphadenopathy in individuals suspected of having LGV.

Bartonella henselae is usually not viable in lymph nodes of patients with cat scratch disease

2017 ◽  
Vol 36 (11) ◽  
pp. 2207-2213 ◽  
Author(s):  
E. Prudent ◽  
H. Lepidi ◽  
G. Audoly ◽  
B. La Scola ◽  
P.-E. Fournier ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Bartonella Henselae ◽  
Cat Scratch Disease

scholarly journals Pediatric Bartonella Infection (Cat Scratch Disease) Presenting as Inguinal Lymphadenopathy

2020 ◽  
Vol 5 ◽  
Author(s):  
Ganesh Maniam ◽  
Aisha Khan ◽  
Raphael Mattamal
Keyword(s):  
Bartonella Henselae ◽  
Surgical Excision ◽  
Empiric Antibiotic Therapy ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Cat Scratch Disease ◽  
Positive Serology ◽  
Recent Infection ◽  
Left Groin ◽  
Inguinal Lymphadenopathy

Cat scratch disease is an infectious disease resulting from inoculation of Bartonella species through a cat scratch or bite, often presenting as an erythematous papule at the site of inoculation with nearby painful lymphadenopathy. The diagnosis of this disease is complicated by a wide variety of clinical presentations, as the primary lesion may not be initially noticed. Furthermore, cervical and axillary lymph nodes are the most commonly involved regions of tender lymphadenopathy, but there have been reported cases that do not fit the typical clinical picture – such the case discussed in this report of a pediatric Bartonella henselae infection that initially presented as left inguinal lymphadenopathy with underlying necrosis and abscess formation. In this case, a 9-year-old boy presented to the ED with a 4-day history of increasing mass in the left groin, as well as a subjective fever for the previous 2 days. An ultrasound revealed a necrotic abscess in the left inguinal lymph node which necessitated empiric antibiotic therapy and surgical excision; titers revealed a recent infection with Bartonella henselae. Atypical presentations of cat scratch disease, such as inguinal lymphadenopathy, have historically confounded the diagnosis. However, positive serology studies ultimately yielded the correct diagnoses in these children. Given that cat scratch disease can present in an atypical fashion in approximately 5 - 25% of cases, physicians should keep the disease on the differential even when presented with rare presentations such as inguinal lymphadenopathy; serological testing for B. henselae can be utilized once more likely etiologies have been ruled out.

scholarly journals Felinosis: the elusive-cat scratch disease

2019 ◽  
Vol 5 (2) ◽  
pp. 511
Author(s):  
S. Arulmozhi ◽  
Sithananda Kumar ◽  
Shilpa Divakaran ◽  
Susy Sophia Kurian ◽  
Mary Kurien
Keyword(s):  
Lymph Nodes ◽  
Children And Adolescents ◽  
Chronic Inflammation ◽  
Male Patient ◽  
Bartonella Henselae ◽  
Clinical Manifestations ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Cat Scratch Disease ◽  
Suppurative Lymphadenitis

<p class="abstract">Cat-scratch disease or felinosis is an infection caused by <em>Bartonella henselae</em> which is characterized by chronic inflammation of the lymph nodes. It is one of the causes of regional, unilateral adenitis in children and adolescents. Axillary lymph nodes followed by cervical, pre-auricular and submandibular lymph nodes are the most common sites of involvement. We report a 14 year old male patient with cat scratch disease in whom the initial clinical manifestations were indistinguishable from those of acute bacterial suppurative lymphadenitis.</p>

scholarly journals Detection by Immunofluorescence Assay of Bartonella henselae in Lymph Nodes from Patients with Cat Scratch Disease

2003 ◽  
Vol 10 (4) ◽  
pp. 686-691 ◽  
Author(s):  
J. M. Rolain ◽  
F. Gouriet ◽  
M. Enea ◽  
M. Aboud ◽  
D. Raoult
Keyword(s):  
Lymph Nodes ◽  
Bartonella Henselae ◽  
Laboratory Diagnosis ◽  
Immunofluorescence Assay ◽  
Cat Scratch Disease ◽  
Specific Monoclonal Antibody ◽  
Pcr Assay ◽  
Serology Test ◽  
Negative Lymph Nodes ◽  
Immunocompetent Patients

ABSTRACT Laboratory diagnosis of Bartonella henselae infections can be accomplished by serology or PCR assay on biopsy samples. The purpose of our work was to assess immunofluorescence detection (IFD) in lymph node smears using a specific monoclonal antibody directed against B. henselae and a commercial serology assay (IFA) compared with PCR detection. Among 200 lymph nodes examined from immunocompetent patients, 54 were positive for B. henselae by PCR, of which 43 were also positive by IFD. Among the 146 PCR-negative lymph nodes, 11 were positive by IFD. Based on PCR results, the specificity of this new technique was 92.5%, the sensitivity was 79.6%, and the positive predictive value was 79.6%. At a cutoff titer of 64, the sensitivity of the IFA was 86.8% and the specificity was 74.1%. Diagnosis of cat scratch disease (CSD) may be improved, with a specificity of 100%, when the two tests (IFD and IFA) were negative; the sensitivity was 97.4% if one of the two tests was positive. Since PCR-based detection with biopsy samples is available only in reference laboratories, we suggest using IFD coupled with the commercial serology test for the diagnosis of CSD.

Other bacterial diseasesCat-scratch disease

2011 ◽  
Author(s):  
Michel Drancourt
Keyword(s):  
Lymph Nodes ◽  
Bartonella Henselae ◽  
Severe Disease ◽  
Formal Description ◽  
Cat Scratch Disease ◽  
Bacillary Angiomatosis ◽  
Children And Young Adults ◽  
Eye Infection ◽  
Rough Play ◽  
Spleen Enlargement

Cat-scratch disease (CSD) is a worldwide zoonoses caused by infection with the bacterium, Bartonella henselae. The formal description of the disease by Debré in 1950 (Debré et al. 1950) corresponds to the most frequently diagnosed form of the disease. Cats are the main reservoir for B. henselae and transmission is via Ctniocephalides felis. Humans usually become infected after being scratched or bitten by a cat and is most frequently seen in children and young adults.CSD is a self-limiting illness which often begins with a small papule developing at the site of cat scratch or bite within 3-14 days of the infection. Nearby lymph nodes, usually neck, axillary or groin, become swollen and can persist for several months. It may take up to 7 weeks for the enlarged lymph nodes to appear and individuals may not recall any cat scratch or bite. In healthy cases antibiotics are not indicated.About 5-10% of patients may develop other forms of CSD including eye infection characterised by conjunctivitis and swollen lymph nodes, rash, liver and spleen enlargement, and more rarely encephalitis. Immunosuppresed patients may develop more severe disease, such as bacillary angiomatosis.General advice for preventing CSD includes avoiding rough play with cats, particularly kittens. Cat scratches and bites should be washed immediately with water and soap and cats should not be allowed to lick open wounds.

Bartonella henselae is a causative agent of cat scratch disease in Australia

1995 ◽  
Vol 31 (3) ◽  
pp. 241-245 ◽  
Author(s):  
J.P. Flexman ◽  
N.J. Lavis ◽  
I.D. Kay ◽  
M. Watson ◽  
C. Metcalf ◽  
...  
Keyword(s):  
Causative Agent ◽  
Bartonella Henselae ◽  
Cat Scratch Disease

scholarly journals Beyond Cat Scratch Disease: A Case Report ofBartonellaInfection Mimicking Vasculitic Disorder

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Amelia Spinella ◽  
Federica Lumetti ◽  
Gilda Sandri ◽  
Valentina Cestelli ◽  
Maria Teresa Mascia
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Bartonella Henselae ◽  
Skin Lesions ◽  
Bacterial Disease ◽  
Cat Scratch Disease ◽  
History Of ◽  
Vasculitic Disorder

Cat scratch disease (CSD) is a bacterial disease caused byBartonella henselaeand it is mainly characterized by self-limiting lymphadenopathy in the draining site of a cat scratch or bite. We report a patient with history of fever, swelling lymph nodes, vasculitic-like skin lesions, and positivity ofBartonellaserology initially considered as expression of a disimmune disease.

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