scholarly journals Clinical observation of adverse drug reactions to non-ionic iodinated contrast media in population with underlying diseases and risk factors

2017 ◽  
Vol 90 (1070) ◽  
pp. 20160729 ◽  
Author(s):  
Xue Li ◽  
Heng Liu ◽  
Li Zhao ◽  
Junling Liu ◽  
Li Cai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Contrast Media ◽  
Adverse Drug Reactions ◽  
Clinical Observation ◽  
Iodinated Contrast Media ◽  
Drug Reactions ◽  
Iodinated Contrast ◽  
Underlying Diseases

Adverse Drug Reactions to Radiographic Contrast Media in a Teaching Hospital in North India: An Observational Study

2019 ◽  
Vol 14 (2) ◽  
pp. 122-126
Author(s):  
Deepti Chopra ◽  
Abhinav Jain ◽  
Richa Garg ◽  
Shreya Dhingra
Keyword(s):  
Observational Study ◽  
Contrast Media ◽  
Adverse Drug Reactions ◽  
Teaching Hospital ◽  
Adverse Reactions ◽  
North India ◽  
Drug Reactions ◽  
Iodinated Contrast ◽  
Radiographic Contrast ◽  
Radiographic Contrast Media

Background: Radiocontrast media are used extensively nowadays to visualize internal organs. Currently, non-ionic iodinated contrast media are used which are generally considered to be safe but some adverse reactions have been reported. Thus, the present study was carried out to analyze the nature and incidence of adverse drug reactions (ADRs) to radiographic contrast media in a teaching hospital. Methods:An observational study carried out for a period of six months in a teaching hospital. Contrast media induced adverse reactions were analyzed in terms of affected organs, rate, causality assessment, severity and preventability. The treatment and outcomes of adverse events were also recorded. Naranjo Probability Scale was used to evaluate the relationship between the contrast agent used and the suspected ADR. The severity of the suspected ADRs was determined using Hartwig Scale and preventability was assessed using modified Schumock and Thornton criterion. Results:A total of 15 suspected ADRs occurred in 11 patients with an incidence of 1.4%. It included 5 (45.4%) males and 6 (54.5%) females (p < 05). The highest percentage (72.7 %) of ADRs was seen in adult patients, the mean age being 40.8 years. Vomiting (33.3%) was the most common ADR noted followed by severe nausea and rashes. 64.7 % of ADRs were categorized as probable and 35.3 % were possible. Adverse reactions required treatment in 46.6% patients. There was no fatality reported. Conclusion:The reactions observed were mild to moderate in severity and occurred within 30 minutes of the administration of the contrast.

scholarly journals Adverse Drug Reactions to CT Contrast Media in South Korea: Incidence and Risk Factors

2016 ◽  
Vol 75 (1) ◽  
pp. 41 ◽  
Author(s):  
Kyungsoo Bae ◽  
Sang Min Lee ◽  
Ji Young Ha ◽  
Kyung Nyeo Jeon ◽  
Jin Il Moon ◽  
...  
Keyword(s):  
Risk Factors ◽  
South Korea ◽  
Contrast Media ◽  
Adverse Drug Reactions ◽  
Drug Reactions ◽  
Ct Contrast

scholarly journals Stratified Assessment and Warning Regimen for Comprehensive Risk Management and Improved Iodinated Contrast Media Safety

2021 ◽  
Author(s):  
Xue Li ◽  
Heng Liu ◽  
Haiyan Qiu ◽  
Lingru Wang ◽  
Junling Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Management ◽  
Contrast Media ◽  
Risk Identification ◽  
Assessment Process ◽  
Iodinated Contrast Media ◽  
Chi Square ◽  
Risk Levels ◽  
Iodinated Contrast ◽  
Assessment Period

Abstract Objectives: To determine the relationship between stratified assessment and warning (SAW) regimen for risk factors to iodinated contrast media (ICM) and adverse drug reactions (ADR) occurrence.Methods: This retrospective study included patients who underwent enhanced CT examinations in our hospital between January 2014 and March 2016 (conventional assessment group) and between April 2017 and December 2019 (SAW group). Initial risk assessment was performed by clinicians when ordering examinations in both periods. The risk re-assessment was performed by simple question-and-answer onsite just before examination in the conventional assessment period, according to the risk factors that deserve special attention in ICM guidelines. In the SAW period, the re-assessment process prior to examination was moved forward as early as possible post-appointment, and a whole-process comprehensive management integrating risk identification, stratification, early warning and prevention was performed according different risk levels. Chi-square test was performed for comparisons of rates.Results: A total of 120822 cases in the conventional assessment group and 150343 cases in the SAW group were enrolled. The total ADR incidence in the SAW period (414/150343, 0.275%) was lower than that in the conventional assessment period (506/120822, 0.419%, P<0.001), in which the proportion of patients who developed ADR decreased by about 34%. It mainly presented as decrease in mild/moderate reactions (P<0.001) and increase in the proportion of mild ADR patients (P=0.001) in the SAW period. Subgroup analysis showed lower mild/moderate ADR incidence in patients with different risk levels and with different ICM injection parameters (P<0.05) following SAW regimen.Conclusions: SAW regimen was associated with lower mild/moderate ADR incidence and alleviated ADR severity in at-risk patients, which held potential for improved risk management and ICM safety.

Safety Essentials: Acute Reactions to Iodinated Contrast Media

2013 ◽  
Vol 64 (3) ◽  
pp. 193-199 ◽  
Author(s):  
Ramesh S. Iyer ◽  
Jennifer G. Schopp ◽  
Jonathan O. Swanson ◽  
Mahesh M. Thapa ◽  
Grace S. Phillips
Keyword(s):  
Risk Factors ◽  
Contrast Media ◽  
Iodinated Contrast Media ◽  
Initial Management ◽  
Treatment Algorithms ◽  
Diagnosis And Management ◽  
Preventative Measures ◽  
Iodinated Contrast ◽  
Specific Reactions

The objectives of this article are to review the diagnosis and management of acute nonrenal reactions to iodinated contrast media. We will begin by discussing the types of contrast media and their correlative rates of reaction. The mechanism of contrast reactions, predisposing risk factors, and preventative measures will then be discussed. The remainder of the article will review the assessment of potential reactions, initial management, and treatment algorithms for specific reactions.

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