The emerging role of medical radiologists in new drug discovery

2005 ◽  
Vol 78 (935) ◽  
pp. 1058-1058 ◽  
Author(s):  
Y-X J Wang
Keyword(s):  
Drug Discovery ◽  
New Drug

Cancer Chemoprevention Effects of Ginger and its Active Constituents: Potential for New Drug Discovery

2015 ◽  
Vol 43 (07) ◽  
pp. 1351-1363 ◽  
Author(s):  
Chong-Zhi Wang ◽  
Lian-Wen Qi ◽  
Chun-Su Yuan
Keyword(s):  
Drug Discovery ◽  
Cancer Chemoprevention ◽  
Lead Compound ◽  
Anticancer Activities ◽  
Anticancer Compounds ◽  
Computational Docking ◽  
Active Constituents ◽  
New Drug ◽  
Anti Cancer

Ginger is a commonly used spice and herbal medicine worldwide. Besides its extensive use as a condiment, ginger has been used in traditional Chinese medicine for the management of various medical conditions. In recent years, ginger has received wide attention due to its observed antiemetic and anticancer activities. This paper reviews the potential role of ginger and its active constituents in cancer chemoprevention. The phytochemistry, bioactivity, and molecular targets of ginger constituents, especially 6-shogaol, are discussed. The content of 6-shogaol is very low in fresh ginger, but significantly higher after steaming. With reported anti-cancer activities, 6-shogaol can be served as a lead compound for new drug discovery. The lead compound derivative synthesis, bioactivity evaluation, and computational docking provide a promising opportunity to identify novel anticancer compounds originating from ginger.

Current Approaches to Drug Discovery for Chagas Disease: Methodological Advances

2019 ◽  
Vol 22 (8) ◽  
pp. 509-520
Author(s):  
Cauê B. Scarim ◽  
Chung M. Chin
Keyword(s):  
Drug Discovery ◽  
Chagas Disease ◽  
Drug Candidates ◽  
Lead Compounds ◽  
New Drug ◽  
Compound Libraries ◽  
Screening Assays ◽  
Cruzi Infection

Background: In recent years, there has been an improvement in the in vitro and in vivo methodology for the screening of anti-chagasic compounds. Millions of compounds can now have their activity evaluated (in large compound libraries) by means of high throughput in vitro screening assays. Objective: Current approaches to drug discovery for Chagas disease. Method: This review article examines the contribution of these methodological advances in medicinal chemistry in the last four years, focusing on Trypanosoma cruzi infection, obtained from the PubMed, Web of Science, and Scopus databases. Results: Here, we have shown that the promise is increasing each year for more lead compounds for the development of a new drug against Chagas disease. Conclusion: There is increased optimism among those working with the objective to find new drug candidates for optimal treatments against Chagas disease.

Sign in / Sign up

Export Citation Format

Share Document