scholarly journals 18FDG-PET/CT findings in COVID-19: a single centre retrospective radiological review

2020 ◽  
Vol 6 (3) ◽  
pp. 20200091 ◽  
Author(s):  
Pia F. P. Charters ◽  
David Little ◽  
Jonathan C. L. Rodrigues ◽  
Richard N Graham ◽  
Stewart L Redman
Keyword(s):  
Fdg Pet ◽  
Low Dose ◽  
Single Centre ◽  
Global Pandemic ◽  
18Fdg Pet ◽  
Clinical Scenarios ◽  
Pet Ct ◽  
The Uk ◽  
Fdg Pet Ct ◽  
Local Protocol

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the infectious disease COVID-19, was declared a global pandemic in March 2020. As radiology departments recommence 18FDG-PET/CT imaging, it is likely that both asymptomatic and specific symptomatic patients with COVID-19 infection will be imaged, particularly if the disease becomes endemic in the UK. We review the clinical scenarios where 18FDG-PET/CT could be performed in COVID-19 positive patients. Our local protocol for safely scanning known COVID-19 positive patients is described, highlighting considerations for other departments. We present the findings from a series of known COVID-19 positive patients and two further asymptomatic cases evaluated with18FDG-PET/CT. Classic, indeterminate, normal and non-COVID-19 manifestations on both the 18FDG-PETand low dose CT component are described as an aid for radiologists and nuclear medicine physicians when reporting 18FDG PET/CT.

scholarly journals Der Beitrag der 18FDG-PET in der Entzündungsdiagnostik

2017 ◽  
Vol 40 (02) ◽  
pp. 119-133
Author(s):  
Martin Gotthardt ◽  
Anja Schlieck ◽  
James Nagarajah ◽  
Erik Aarntzen
Keyword(s):  
Fdg Pet ◽  
Low Dose ◽  
Wird Eine ◽  
Fieber Unklarer Genese ◽  
Low Dose Ct ◽  
18Fdg Pet ◽  
Pet Ct ◽  
Fdg Pet Ct

ZusammenfassungDie 18FDG-PET/CT kann bei der Diagnostik entzündlicher Erkrankungen eine entscheidende Rolle spielen. Die PET/CT kombiniert die Möglichkeit der Ganzkörperaufnahme mit einer guten anatomischen Zuordnung von Befunden durch die simultan durchgeführte low dose CT. Sie ist daher eine exzellente Technik nicht nur für die Suche nach Entzündungsherden, sondern auch für die differenzialdiagnostische Unterscheidung von entzündlichen /Autoimmun-Erkrankungen und Tumorerkrankungen. Die hohe Sensitivität geht jedoch mit einer eher geringen Spezifität der FDG-Aufnahme einher. Daher ist die Erkennung bestimmter Muster und die korrekte Interpretation der Verteilung von Läsionen zusammen mit dem klinischen Kontext entscheidend für den Beitrag der FDG-PET/CT im Hinblick auf das klinische Management von Patienten. In dieser Arbeit wird eine Übersicht über die möglichen Ursachen und pathophysiologischen Mechanismen entzündlicher Erkrankungen (wie z. B. Sarkoidose, entzündliche Lungenerkrankungen, Osteomyelitis, Fieber unklarer Genese, Infektionen von Gefäßprothesen, Streuherde bei Infektionserkrankungen, etc.), sowie die damit verbundenen typischen Muster der FDG-Anreicherung gegeben. Weiterhin werden Differenzialdiagnosen diskutiert und Hinweise zur optimalen Bildinterpretation gegeben.

scholarly journals Use of 18F-FDG-PET-CT in glioma surveillance: A single centre experience

2018 ◽  
Vol 20 (suppl_1) ◽  
pp. i24-i24
Author(s):  
Beverly Cheserem ◽  
Bernadett Kovacs ◽  
Sorin Bucur ◽  
Sabina Dizdarevic ◽  
Giles Critchley
Keyword(s):  
Fdg Pet ◽  
Single Centre ◽  
Pet Ct ◽  
Single Centre Experience ◽  
18F Fdg ◽  
Fdg Pet Ct

Imaging myeloma and related monoclonal plasma cell disorders using MRI, low-dose whole-body CT and FDG PET/CT

2015 ◽  
Vol 3 (2) ◽  
pp. 95-109
Author(s):  
N. Withofs ◽  
C. Nanni ◽  
P. Simoni ◽  
S. Fanti ◽  
Y. Beguin ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Fdg Pet ◽  
Low Dose ◽  
Whole Body ◽  
Whole Body Ct ◽  
Pet Ct ◽  
Plasma Cell Disorders ◽  
Fdg Pet Ct ◽  
Body Ct

The effects of chemotherapy on arterial inflammation assessed by 18 FDG PET-CT in patients with Lymphoma

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
E Solomou ◽  
I Koutagiar ◽  
N Ioakimidis ◽  
D Terentes-Printzios ◽  
A Georgakopoulos ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Heart Function ◽  
Specific Treatment ◽  
Chemotherapy Cycle ◽  
Treatment Regimes ◽  
18Fdg Pet ◽  
Pet Ct ◽  
Study Population ◽  
Arterial Inflammation ◽  
Fdg Pet Ct

Abstract Introduction Anti-cancer treatment can lead to increased cardiovascular morbidity among lymphoma survivors. This may be the result of direct effect of treatment on heart function, or indirect acceleration of atherosclerosis. 18F-fluorodeoxyglucose (FDG) uptake is a sensitive and robust marker for assessment of atherosclerotic inflammation. Purpose To investigate the effects of chemotherapy on arterial inflammation using FDG-PET CT in patients with lymphoma. Methods Fifty nine (mean age 58±17 years) patients with Hodgkin (n=39) or non-Hodgkin lymphomas (n=20) underwent 18FDG PET-CT imaging at baseline, interim and after completion of chemotherapy as part of their routine protocol. Arterial inflammation was assessed by arterial target to background ratio (TBR) of the aortic wall along the entire aorta. The index vessel TBR (the vessel with the higher value at baseline) was used for assessment of arterial inflammation. Patients with Hodgkin Lymphomas (HL) underwent therapy with Doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD). The interim of their treatment was set at 1 to 3 days prior to initiating the 3rd chemotherapy cycle. Patients with non Hodgkin Lymphomas (NHL) underwent therapy with cyclophosphamide, doxorubicin, vincristine, and prednisone+rituximab (R-CHOP). The interim of their treatment was set at 2 weeks post the 4th chemotherapy cycle. All patients we reassessed 6 weeks after chemotherapy completion. Results There were no differences in age and atherosclerotic risk factors (hypertension, diabetes, dyslipidemia and smoking), between the two groups (all P>0.05). Similarly, there were no differences in mean (±SD) index vessel TBR between HL and NHL patients (2.4±0.7 vs 2.7±0.9, respectively, P=0.65). In the whole study population the index vessel TBR progressively decreased after the end of therapy (by 0.53±0.11, from baseline to 6 weeks following the end of therapies) (F=10.94, P<0.001, ANOVA). The index vessel TBR decreased in both HL and NHL patients at 6 weeks after therapy compared to baseline level (all P<0.01, ANOVA, figure). The decrease at the interim scan was more pronounced in NHL compared to HL patients, however at 6 weeks after chemotherapy completion the index vessel TBR decreased further in patients with HL, while it increased slightly compared to interim levels in NHL patients (figure 1). Conclusion Arterial inflammation is reduced during and post-chemotherapy in patients with lymphoma. The index vessel TBR changes at the interim phase and 6 weeks after therapy completion indicate a different effect of specific treatment regimes in arterial inflammation between HL and NHL patients. Figure 1 Funding Acknowledgement Type of funding source: None

scholarly journals Protocols for Harmonized Quantification and Noise Reduction in Low-Dose Oncologic 18F-FDG PET/CT Imaging

2018 ◽  
Vol 47 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Marcos A.D. Machado ◽  
Vinícius O. Menezes ◽  
Mauro Namías ◽  
Naiara S. Vieira ◽  
Cleiton C. Queiroz ◽  
...  
Keyword(s):  
Noise Reduction ◽  
Fdg Pet ◽  
Low Dose ◽  
Ct Imaging ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals NGHIÊN CỨU GIÁ TRỊ CỦA 18FDG PET/CT DỰ ĐOÁN TÌNH TRẠNG ĐỘT BIẾN GEN EGFR Ở BỆNH NHÂN UNG THƯ PHỔI BIỂU MÔ TUYẾN

2022 ◽  
Vol 509 (1) ◽  
Author(s):  
Bùi Tiến Công ◽  
Phạm Văn Thái ◽  
Phạm Cẩm Phương ◽  
Đồng Thị Hằng ◽  
Phạm Văn Tuyến ◽  
...  
Keyword(s):  
Fdg Pet ◽  
18Fdg Pet ◽  
Pet Ct ◽  
Fdg Pet Ct

Mục tiêu nghiên cứu: Nghiên cứu giá trị của FDG PET/CT dự đoán tình trạng đột biến EGFR ở bệnh nhân ung thư phổi biểu mô tuyến. Đối tượng và phương pháp nghiên cứu: 114 bệnh nhân ung thư biểu mô tuyến của phổi giai đoạn IIIb, IV được chụp FDG PET/CT, xét nghiệm EGFR trước điều trị từ 11/2018 đến 07/2020. Kết quả: Độ tuổi trung bình 62,3± 8,4, tỷ lệ nam (63,2%) nữ (36,8%), giai đoạn IIIb (43,0%) và giai đoạn IV (57,0%). 43,0% bệnh nhân nghiên cứu không bộc lộ PD L1, 57,0% BN nghiên cứu có kết quả xét nghiệm PD L1 dương tính mức độ yếu đến mạnh.  Tỉ lệ đột biến gen EGFR và tỷ lệ không có đột biến tương ứng 55,3% và 44,7%. Giá trị SUVmax tại khối u phổi nguyên phát ở nhóm EGFR dương tính (11,2 ±5,7) thấp hơn có ý nghĩa thống kê so với nhóm EGFR âm tính (15,8±6,2) (p=0,04). Sử dụng biểu đồ ROC cho thấy, diện tích dưới đường cong (AUC) của SUVmax trong chẩn đoán EGFR dương tính là 0,654 (p<0,05). Kết hợp 4 yếu tố SUVmax, giới, tiền sử lá hút thuốc, cho kết quả chẩn đoán EGFR dương tính tốt hơn, cụ thể diện tích dưới đường cong (AUC) của 4 yếu tố là 0,706 (p<0,05). Kết luận: Đặc điểm FDG PET/CT có mối liên quan và có giá trị dự đoán tình trạng đột biến EGFR ở bệnh nhân ung thư biểu mô tuyến của phổi

Very low-dose adult whole-body tumor imaging with F-18 FDG PET/CT

2015 ◽  
Author(s):  
Andrzej Krol ◽  
Muhammad Naveed ◽  
Mary McGrath ◽  
Michele Lisi ◽  
Cathy Lavalley ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Low Dose ◽  
Tumor Imaging ◽  
Whole Body ◽  
Pet Ct ◽  
Fdg Pet Ct
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