scholarly journals Response to Penicillin for Presumed Neurosyphilis in a Patient with Human Immunodeficiency Virus (HIV), a Normal CD4 Count, and an Undetectable Viral Load: A Case Report

2021 ◽  
Vol 22 ◽  
Author(s):  
Yasameen E. Muzahim ◽  
Muhammad S. Khan ◽  
Harold P. Katner
Keyword(s):  
Human Immunodeficiency Virus ◽  
Case Report ◽  
Viral Load ◽  
Undetectable Viral Load ◽  
Cd4 Count ◽  
Immunodeficiency Virus

scholarly journals Frequency of Cytomegalovirus Viral Load in Iranian Human Immunodeficiency Virus-1-Infected Patients with CD4+ Counts <100 Cells/mm3

Intervirology ◽  
2021 ◽  
pp. 1-5
Author(s):  
Mohammad Reza Jabbari ◽  
Hoorieh Soleimanjahi ◽  
Somayeh Shatizadeh Malekshahi ◽  
Mohammad Gholami ◽  
Leila Sadeghi ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Viral Load ◽  
Cell Count ◽  
Previous History ◽  
Cd4 Count ◽  
Cd4 Cell Count ◽  
Cell Counts ◽  
Immunodeficiency Virus ◽  
Cd4 Cell ◽  
Hiv 1

<b><i>Objectives:</i></b> The aim of present work was to assess cytomegalovirus (CMV) viremia in Iranian human immunodeficiency virus (HIV)-1-infected patients with a CD4+ count &#x3c;100 cells/mm<sup>3</sup> and to explore whether CMV DNA loads correlate with CD4+ cell counts or associated retinitis. <b><i>Methods:</i></b> This study was conducted at the AIDS research center in Iran on HIV-1-infected patients with CD4+ count &#x3c;100 cells/mm<sup>3</sup>, antiretroviral therapy-naive, aged ≥18 years with no previous history of CMV end-organ disease (CMV-EOD). <b><i>Results:</i></b> Thirty-nine of 82 patients (47.56%) had detectable CMV viral load ranging from 66 to 485,500 IU/mL. CMV viral load in patients with retinitis ranges from 352 to 2,720 IU/mL, and it was undetectable in 2 patients. No significant associations between CMV viremia and CD4+ cell count was found (<i>p</i> value = 0.31), whereas significant association of CMV viremia in HIV-infected patients with retinitis was found (<i>p</i> &#x3c; 0.02). <b><i>Conclusions:</i></b> We estimated the frequency of CMV viral load infection in Iranian HIV-1-infected patients with a CD4+ cell count &#x3c;100 mm<sup>3</sup>/mL in the largest national referral center for HIV-1 infection in Iran. Further research is required on the relevance of CMV viral load in diagnostic and prognostic value of CMV-EOD.

scholarly journals Association of Multiple Primary Skin Cancers With Human Immunodeficiency Virus Infection, CD4 Count, and Viral Load

2017 ◽  
Vol 153 (9) ◽  
pp. 892 ◽  
Author(s):  
Maryam M. Asgari ◽  
G. Thomas Ray ◽  
Charles P. Quesenberry ◽  
Kenneth A. Katz ◽  
Michael J. Silverberg
Keyword(s):  
Human Immunodeficiency Virus ◽  
Viral Load ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Cd4 Count ◽  
Skin Cancers ◽  
Immunodeficiency Virus ◽  
Multiple Primary

Psychosis Induced by Decreased CD4+ T Cell and High Viral Load in Human Immunodeficiency Virus Infection: A Case Report

2008 ◽  
Vol 64 (9) ◽  
pp. e3-e4 ◽  
Author(s):  
Mar Álvarez-Segura ◽  
Sonia Villero ◽  
Enrique Portugal ◽  
Maria Mayoral ◽  
Pedro Montilla ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Case Report ◽  
Viral Load ◽  
T Cell ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
High Viral Load ◽  
Cd4 T Cell ◽  
Immunodeficiency Virus

scholarly journals Decay Kinetics of Human Immunodeficiency Virus-Specific CD8+ T Cells in Peripheral Blood after Initiation of Highly Active Antiretroviral Therapy

2001 ◽  
Vol 75 (14) ◽  
pp. 6508-6516 ◽  
Author(s):  
Joseph P. Casazza ◽  
Michael R. Betts ◽  
Louis J. Picker ◽  
Richard A. Koup
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cells ◽  
Viral Load ◽  
T Cell ◽  
Cell Response ◽  
Highly Active Antiretroviral Therapy ◽  
Undetectable Viral Load ◽  
T Cell Response ◽  
Highly Active ◽  
Immunodeficiency Virus

ABSTRACT We measured the longitudinal responses to 95 HLA class I-restricted human immunodeficiency virus (HIV) epitopes and an immunodominant HLA A2-restricted cytomegalovirus (CMV) epitope in eight treatment-naive HIV-infected individuals, using intracellular cytokine staining. Patients were treated with highly active antiretroviral therapy (HAART) for a median of 78 weeks (range, 34 to 121 weeks). Seven of eight patients maintained an undetectable viral load for the duration of therapy. A rapid decline in HIV-specific CD8+ T-cell response was observed at initiation of therapy. After an undetectable viral load was achieved, a slower decrease in HIV-specific CD8+ T-cell response was observed that was well described by first-order kinetics. The median half-life for the rate of decay was 38.8 (20.3 to 68.0) weeks when data were expressed as percentage of peripheral CD8+ T cells. In most cases, data were similar when expressed as the number of responding CD8+ T cells per microliter of blood. In subjects who responded to more than one HIV epitope, rates of decline in response to the different epitopes were similar and varied by a factor of 2.2 or less. Discontinuation of treatment resulted in a rapid increase in HIV-specific CD8+ T cells. Responses to CMV increased 1.6- and 2.8-fold within 16 weeks of initiation of HAART in two of three patients with a measurable CMV response. These data suggest that HAART quickly starts to restore CD8+ T-cell responses to other chronic viral infections and leads to a slow decrease in HIV-specific CD8+ T-cell response in HIV-infected patients. The slow decrease in the rate of CD8+ T-cell response and rapid increase in response to recurrent viral replication suggest that the decrease in CD8+ T-cell response observed represents a normal memory response to withdrawal of antigen.

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