Evalution of Renal Involvement in Patients with Behçet Disease: Need to be Aware About Potential Hypertension in Long Term Follow Up?

Behcet disease is rare in children. There are only two reports of Behcet disease in childhood, describing seven patients. Three pediatric patients are described, in whom the age of onset ranged from 6 to 11 years. Aphthous stomatitis and arthritis were present in all of the patients; genital ulcers, iridocylitis, erythema nodosum, and CNS involvement were present in two patients. Other manifestations included Stevens-Johnson-like eruption, fever of unknown origin, and testicular involvement. All of the patients responded to glucocorticoids; two were also treated with colchicine and one was treated with chlorambucil. In two patients, follow-up of more than 10 years was done, with complete cure in one patient and benign course of illness in the other. Because of the rarity of the disease in childhood and the difficulty in making the diagnosis, there is not enough awareness by pediatricians concerning this disease.

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A case of Behcet disease with pulmonary artery pseudoaneurysm: long term follow-up

Eastern Mediterranean Health Journal ◽

10.26719/2010.16.3.346 ◽

2010 ◽

Vol 16 (03) ◽

pp. 346-349 ◽

Cited By ~ 1

Author(s):

M.H.S. Modaghegh ◽

G.H. Kazemzadeh ◽

M.H. Jokar

Keyword(s):

Pulmonary Artery ◽

Behçet Disease ◽

Behcet Disease ◽

Artery Pseudoaneurysm ◽

Long Term Follow Up ◽

Pulmonary Artery Pseudoaneurysm

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Five non-mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes phenotype adult patients with m.3243A>G mutation after kidney transplantation: follow-up and review of the literature

Clinical Kidney Journal ◽

10.1093/ckj/sfz020 ◽

2019 ◽

Vol 12 (6) ◽

pp. 840-846 ◽

Cited By ~ 2

Author(s):

Paul de Laat ◽

Nienke van Engelen ◽

Jack F Wetzels ◽

Jan A M Smeitink ◽

Mirian C H Janssen

Keyword(s):

Kidney Transplantation ◽

Lactic Acidosis ◽

Renal Disease ◽

Mitochondrial Myopathy ◽

Renal Involvement ◽

Adequate Treatment ◽

Number Of Patients ◽

Long Term Follow Up

Abstract Background Renal involvement in patients with the m.3243A>G mutation may result in end-stage renal disease (ESRD) requiring renal replacement therapy. Although kidney transplantations have been performed in a small number of patients, short- and long-term follow-up data are lacking. Methods We describe five patients with the m.3243A<G mutation who received a kidney transplant, including follow-up data up to 13 years. We also summarize all cases (n = 13) of kidney transplantation in m.3243A>G carriers described in the literature. Results Proteinuria with or without renal failure was the first clinical presentation of renal involvement in 13 of 18 (72%) patients. Focal segmental glomerulosclerosis (FSGS) was found in 9 of 13 (69%) biopsies. Sixteen of 18 (84%) patients developed hearing loss. All patients were diagnosed with diabetes mellitus, of whom eight (44%) developed the disease after transplantation. All patients with reported follow-up data (13/18) had stable kidney function from 6 months to 13 years of follow-up after transplantation. Conclusions Renal involvement in carriers of the m.3243A>G mutation most commonly leads to proteinuria and FSGS and may lead to ESRD. Proper recognition of the mitochondrial origin of the renal disease in these patients is important for adequate treatment selection and suitable supportive care. This case series and review of the available literature on long-term follow-up after kidney transplantation shows it is feasible for non-mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes phenotype carriers of the m.3243A>G mutation to be considered for kidney transplantation in case of ESRD. These patients should not be excluded from transplant solely for their mitochondrial diagnosis.

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SP114SECONDARY AMYLOIDOSIS WITH RENAL INVOLVEMENT AND HISTOPATHOLOGIC CORRELATION. LONG TERM FOLLOW-UP RESULTS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfv188.77 ◽

2015 ◽

Vol 30 (suppl_3) ◽

pp. iii415-iii415

Author(s):

Zeynep Kendi Celebi ◽

Saba Kiremitci ◽

Bengi Ozturk ◽

Serkan Akturk ◽

Siyar Erdogmus ◽

...

Keyword(s):

Renal Involvement ◽

Long Term Follow Up

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Absence of clinical abnormalities suggesting renal involvement during the long-term course of visceral Leishmaniasis

Revista da Sociedade Brasileira de Medicina Tropical ◽

10.1590/s0037-86821986000400002 ◽

1986 ◽

Vol 19 (4) ◽

pp. 209-212 ◽

Cited By ~ 2

Author(s):

Reinaldo Martinelli ◽

Rosemarie Lorenço ◽

Heonir Rocha

Keyword(s):

Renal Function ◽

Visceral Leishmaniasis ◽

Renal Involvement ◽

Parasitic Infection ◽

Clinical Findings ◽

Laboratory Evaluation ◽

Control Group ◽

Long Term Follow Up

Abnormalities of renal function have been demonstrated inpatients with visceral leishmaniasis; although there was a trend toward normalization following antiparasitic therapy, some abnormalities persisted. With thepurpose of studying the long- term clinical course of renal involvement in visceral leishmaniasis, 32 patients with a diagnosis of this parasitic disease were evaluated in the endemic area and at least 6 months after the clinical cure of the disease and compared with a control group of 28 individuals. No patient had a history or clinical findings suggestive of renal disease and all were normotensive. Laboratory evaluation was normal in all except 3 patients with abnormal urinalysis. Mild proteinuria and microscopic hematuria were seen in a single urinalysis in one patient (although three other urinalysis were normal), and leucocyturia in two female patients. It was concluded that the renal involvement in visceral leishmaniasis is mild and transient, with normal renal function observed on long-term follow-up after cure of the parasitic infection.

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Renal involvement in children with HNF1β mutation: Early sonographic appearances and long-term follow-up

European Radiology ◽

10.1007/s00330-014-3550-x ◽

2015 ◽

Vol 25 (5) ◽

pp. 1479-1486 ◽

Cited By ~ 2

Author(s):

Fred E. Avni ◽

Annie Lahoche ◽

Carole Langlois ◽

Catherine Garel ◽

Michele Hall ◽

...

Keyword(s):

Renal Involvement ◽

Long Term Follow Up

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Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?

Behavioral and Brain Sciences ◽

10.1017/s0140525x1800105x ◽

2019 ◽

Vol 42 ◽

Cited By ~ 2

Author(s):

John P. A. Ioannidis

Keyword(s):

Mental Health ◽

Mental Disease ◽

Brain Disorders ◽

Social Stressors ◽

Labor Education ◽

Mental Diseases ◽

Long Term Follow Up ◽

Political Decisions

AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.

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