Bioreactor Process Selection for Large-Scale Manufacture of Monoclonal Antibodies — Tradeoffs and Recommendations

2003 ◽  
Vol 2 (3) ◽  
pp. 25-31 ◽  
Author(s):  
Mina Mahadevan
Keyword(s):  
Monoclonal Antibodies ◽  
Large Scale ◽  
Process Selection ◽  
Selection For ◽  
Large Scale Manufacture ◽  
Bioreactor Process

scholarly journals Monoclonal Antibodies Targeting CGRP: From Clinical Studies to Real-World Evidence—What Do We Know So Far?

2021 ◽  
Vol 14 (7) ◽  
pp. 700
Author(s):  
Theodoros Mavridis ◽  
Christina I. Deligianni ◽  
Georgios Karagiorgis ◽  
Ariadne Daponte ◽  
Marianthi Breza ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Real World ◽  
Large Scale ◽  
Randomized Clinical Trials ◽  
Clinical Investigation ◽  
Phase Iii ◽  
Real World Evidence ◽  
Symptomatic Management ◽  
Repurposed Drugs ◽  
Cephalic Pain

Now more than ever is the time of monoclonal antibody use in neurology. In headaches, disease-specific and mechanism-based treatments existed only for symptomatic management of migraines (i.e., triptans), while the standard prophylactic anti-migraine treatments consist of non-specific and repurposed drugs that share limited safety profiles and high risk for interactions with other medications, resulting in rundown adherence rates. Recent advances in headache science have increased our understanding of the role of calcitonin gene relate peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) pathways in cephalic pain neurotransmission and peripheral or central sensitization, leading to the development of monoclonal antibodies (mAbs) or small molecules targeting these neuropeptides or their receptors. Large scale randomized clinical trials confirmed that inhibition of the CGRP system attenuates migraine, while the PACAP mediated nociception is still under scientific and clinical investigation. In this review, we provide the latest clinical evidence for the use of anti-CGRP in migraine prevention with emphasis on efficacy and safety outcomes from Phase III and real-world studies.

Integrating landscape resistance and multi-scale predictor of habitat selection for amphibian distribution modelling at large scale

2021 ◽  
Author(s):  
Florence Matutini ◽  
Jacques Baudry ◽  
Marie-Josée Fortin ◽  
Guillaume Pain ◽  
Joséphine Pithon
Keyword(s):  
Habitat Selection ◽  
Large Scale ◽  
Landscape Resistance ◽  
Distribution Modelling ◽  
Multi Scale ◽  
Selection For

Data-Driven Lightweight Interest Point Selection for Large-Scale Visual Search

2018 ◽  
Vol 20 (10) ◽  
pp. 2774-2787 ◽  
Author(s):  
Feng Gao ◽  
Xinfeng Zhang ◽  
Yicheng Huang ◽  
Yong Luo ◽  
Xiaoming Li ◽  
...  
Keyword(s):  
Visual Search ◽  
Large Scale ◽  
Data Driven ◽  
Interest Point ◽  
Point Selection ◽  
Selection For

scholarly journals Metachronal waves in magnetic micro-robotic paddles for artificial cilia

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Matthew T. Bryan ◽  
Elizabeth L. Martin ◽  
Aleksandra Pac ◽  
Andrew D. Gilbert ◽  
Feodor Y. Ogrin
Keyword(s):  
Large Scale ◽  
Point Of Care ◽  
Hydrodynamic Response ◽  
Flow Speeds ◽  
Break Time ◽  
Large Scale Manufacture ◽  
Fresh Insight ◽  
Metachronal Waves ◽  
Insight Into ◽  
Phase Differences

AbstractBiological cilia generate fluid movement within viscosity-dominated environments using beating motions that break time-reversal symmetry. This creates a metachronal wave, which enhances flow efficiency. Artificially mimicking this behaviour could improve microfluidic point-of-care devices, since viscosity-dominated fluid dynamics impede fluid flow and mixing of reagents, limiting potential for multiplexing diagnostic tests. However, current biomimicry schemes require either variation in the hydrodynamic response across a cilia array or a complex magnetic anisotropy configuration to synchronise the actuation sequence with the driving field. Here, we show that simple modifications to the structural design introduce phase differences between individual actuators, leading to the spontaneous formation of metachronal waves. This generates flow speeds of up to 16 μm/s as far as 675 μm above the actuator plane. By introducing metachronal waves through lithographic structuring, large scale manufacture becomes feasible. Additionally, by demonstrating that metachronal waves emerge from non-uniformity in internal structural mechanics, we offer fresh insight into the mechanics of cilia coordination.

Robust Relay Selection for Large-Scale Energy-Harvesting IoT Networks

2017 ◽  
Vol 4 (2) ◽  
pp. 384-392 ◽  
Author(s):  
Hiroki Kawabata ◽  
Koji Ishibashi ◽  
Satyanarayana Vuppala ◽  
Giuseppe T. F. de Abreu
Keyword(s):  
Energy Harvesting ◽  
Relay Selection ◽  
Large Scale ◽  
Selection For
Sign in / Sign up

Export Citation Format

Share Document