Construction of the Physiological Toxicokinetic Model of Bisphenol A

Abstract • Background: Dietary intake is the predominant route for human exposure to bisphenol A and one of the food items important for humans is milk, and BPA-polluted animal feed and environments may thus affect human exposure. The aim of our study was to evaluate the BPA exposure and disposition in sheep milk after repeated dietary and subcutaneous administration of a relatively low dose (100 µg/kg of body weight per day) of BPA to a sheep. • Results: With our toxicokinetic model, we showed that most likely only free BPA passes into the mammary gland and is subsequently conjugated there. The percentage of the dose eliminated with milk was less than 0.1%, regardless of the route of BPA administration. • Conclusions: It is proven that the BPA is eliminated through the milk of lactating sheep. However, the amounts excreted in the milk that were detected in this study are minimal.

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Prediction of human prenatal exposure to bisphenol A and bisphenol A glucuronide from an ovine semi-physiological toxicokinetic model

Scientific Reports ◽

10.1038/s41598-017-15646-5 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 7

Author(s):

Glenn Gauderat ◽

Nicole Picard-Hagen ◽

Pierre-Louis Toutain ◽

Rémi Servien ◽

Catherine Viguié ◽

...

Keyword(s):

Bisphenol A ◽

Prenatal Exposure ◽

Toxicokinetic Model

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Predicting Plasma Concentrations of Bisphenol A in Children Younger Than 2 Years of Age after Typical Feeding Schedules, using a Physiologically Based Toxicokinetic Model

Environmental Health Perspectives ◽

10.1289/ehp.0800073 ◽

2009 ◽

Vol 117 (4) ◽

pp. 645-652 ◽

Cited By ~ 105

Author(s):

Andrea N. Edginton ◽

Len Ritter

Keyword(s):

Bisphenol A ◽

Plasma Concentrations ◽

Physiologically Based ◽

Toxicokinetic Model

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Probing the Chemistry and Spectroscopy of Radiation-Sensitive Polymers by Parallel-Detection EELS

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010013376x ◽

1990 ◽

Vol 48 (2) ◽

pp. 34-35

Author(s):

E. G. Rightor ◽

G. P. Young

Keyword(s):

Electron Beam ◽

Bisphenol A ◽

Energy Loss ◽

Parallel Detection ◽

Commercial Grade ◽

Incident Electron Beam ◽

Ptfe Sample ◽

Spectroscopic Information ◽

Edge Features ◽

Electron Energy Loss

Investigation of neat polymers by TEM is often thwarted by their sensitivity to the incident electron beam, which also limits the usefulness of chemical and spectroscopic information available by electron energy loss spectroscopy (EELS) for these materials. However, parallel-detection EELS systems allow reduced radiation damage, due to their far greater efficiency, thereby promoting their use to obtain this information for polymers. This is evident in qualitative identification of beam sensitive components in polymer blends and detailed investigations of near-edge features of homopolymers.Spectra were obtained for a poly(bisphenol-A carbonate) (BPAC) blend containing poly(tetrafluoroethylene) (PTFE) using a parallel-EELS and a serial-EELS (Gatan 666, 607) for comparison. A series of homopolymers was also examined using parallel-EELS on a JEOL 2000FX TEM employing a LaB6 filament at 100 kV. Pure homopolymers were obtained from Scientific Polymer Products. The PTFE sample was commercial grade. Polymers were microtomed on a Reichert-Jung Ultracut E and placed on holey carbon grids.

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