Seeds of Asclepias syriaca L. (milkweed) have an inherent dormancy and these seeds could be forced to germinate by various treatments including stratification, cutting or removal of the seed coat, gases, alternating temperature, and a number of chemicals. Of the various treatments, the growth regulators kinetin and gibberellic acid were most effective in overcoming dormancy and a combination of these two had a synergistic effect. The increased germination percentage after 5 weeks of stratification was not accompanied by an increase in endogenous gibberellin levels. Treatment of the seeds with abscisic acid after stratification resulted in a complete inhibition of germination whereas treatment with kinetin resulted in an increase in germination. It is concluded that dormancy in milkweed seeds could be broken by many factors and regulated by an intricate interplay between growth promoters and inhibitors.