Mutual Binding Inhibition of Tetrodotoxin and Saxitoxin to Their Binding Protein from the Plasma of the Puffer Fish,Fugu pardalis

2002 ◽  
Vol 66 (11) ◽  
pp. 2520-2524 ◽  
Author(s):  
Mari YOTSU-YAMASHITA ◽  
Yuki SHOJI ◽  
Takahiro TERAKAWA ◽  
Shunichi YAMADA ◽  
Teruo MIYAZAWA ◽  
...  
Keyword(s):  
Binding Protein ◽  
Binding Inhibition ◽  
Puffer Fish

scholarly journals The Blood Stage Antigen RBP2-P1 of Plasmodium vivax Binds Reticulocytes and Is a Target of Naturally Acquired Immunity

2020 ◽  
Vol 88 (4) ◽  
Author(s):  
Anongruk Chim-Ong ◽  
Thitiporn Surit ◽  
Sittinont Chainarin ◽  
Wanlapa Roobsoong ◽  
Jetsumon Sattabongkot ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
Malaria Vaccine ◽  
Vaccine Development ◽  
Binding Protein ◽  
Blood Stage ◽  
Content Type ◽  
Binding Inhibition ◽  
Erythrocyte Binding ◽  
Blood Stage Malaria

ABSTRACT The interactions between Plasmodium parasites and human erythrocytes are prime targets of blood stage malaria vaccine development. The reticulocyte binding protein 2-P1 (RBP2-P1) of Plasmodium vivax, a member of the reticulocyte binding protein family, has recently been shown to be highly antigenic in several settings endemic for malaria. Yet, its functional characteristics and the relevance of its antibody response in human malaria have not been examined. In this study, the potential function of RBP2-P1 as an invasion ligand of P. vivax was evaluated. The protein was found to be expressed in schizonts, be localized at the apical end of the merozoite, and preferentially bind reticulocytes over normocytes. Human antibodies to this protein also exhibit erythrocyte binding inhibition at physiologically relevant concentrations. Furthermore, RBP2-P1 antibodies are associated with lower parasitemia and tend to be higher in asymptomatic carriers than in patients. This study provides evidence supporting a role of RBP2-P1 as an invasion ligand and its consideration as a vaccine target.

Purification, characterization, and cDNA cloning of a novel soluble saxitoxin and tetrodotoxin binding protein from plasma of the puffer fish, Fugu pardalis

2001 ◽  
Vol 268 (22) ◽  
pp. 5937-5946 ◽  
Author(s):  
Mari Yotsu-Yamashita ◽  
Atsuko Sugimoto ◽  
Takahiro Terakawa ◽  
Yuki Shoji ◽  
Teruo Miyazawa ◽  
...  
Keyword(s):  
Cdna Cloning ◽  
Binding Protein ◽  
Puffer Fish

scholarly journals Tetrodotoxin binding protein in the marine puffer fish

2021 ◽  
Vol 6 (1) ◽  
pp. 39-52
Author(s):  
Bahar TOKUR ◽  
Koray KORKMAZ
Keyword(s):  
Binding Protein ◽  
Puffer Fish

Kupffer cell activation by LPS is mediated via LPS binding protein and CD14

2001 ◽  
Vol 120 (5) ◽  
pp. A27-A27
Author(s):  
M FAN ◽  
S GOYERT ◽  
A AMINLARI ◽  
R KLEIN ◽  
L STEINSTRAESSER ◽  
...  
Keyword(s):  
Kupffer Cell ◽  
Cell Activation ◽  
Binding Protein ◽  
Lps Binding

Annexin VI is a Ca2+-sensitive CHSP-28 binding protein present on secretory granule membranes in acini

2001 ◽  
Vol 120 (5) ◽  
pp. A336-A336
Author(s):  
G GROBLEWSKI ◽  
D THOMAS ◽  
W TAFT ◽  
K KASPAR
Keyword(s):  
Secretory Granule ◽  
Binding Protein ◽  
Annexin Vi

235: The RNA-Binding Protein IMP3: A Novel Molecular Marker Predicts Progression of Superficial (TA and T1) Urothelial Carcinomas of Bladder

2007 ◽  
Vol 177 (4S) ◽  
pp. 78-79
Author(s):  
Lioudmila Sitnikova ◽  
Gary Mendese ◽  
Qin Lui ◽  
Bruce A. Woda ◽  
Di Lu ◽  
...  
Keyword(s):  
Molecular Marker ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Urothelial Carcinomas
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