As the number of single mothers worldwide increases, their challenges and health issues were discussed in the previous literature. This systematic analysis aims to reveal mental health problems of single-mothers and discuss the adversities faced by them. Financial hardship was seemingly the most significant problem among the low incomes, unemployed and poor single mothers, which showed that poverty and mental health problems were inextricably related. Several factors were found in this study, which has led the single mothers to poverty, such as lowincome employment, large numbers of self-employment, unemployed, low education level, lack of adequate skills and age factor. In addition to that, numerous lines of research have indicated that low social support from the surrounding area was the factor of the distress of single mothers. Previous studies showed that single mothers use negative coping strategies, for example, consuming drugs, cigarettes, alcohol, and antidepressants to alleviate the effects of stressful life. These coping strategies were found to be harmful to their physical and mental health. Therefore, suggestions and recommendations are provided to improve the lives of single mothers and their children to accomplish quality of life.