Impact of Diabetes Duration on the Extent and Severity of Coronary Atheroma Burden in Type 2 Diabetic Patients : Evaluation by Coronary CT Angiography

Abstract Funding Acknowledgements Type of funding sources: None. Introdution The use of coronary angiography by cardiac CT for the active search for coronary disease in asymptomatic diabetic patients is not generally indicated. On the other hand, in the case of high-risk patients with a high calcium score, there are results that do show a potential benefit of expanding the study with CT coronary angiography. Purpose The aim was to determine the medium-term prognostic value of computed tomography non-invasive coronary angiography (CT angiography) to predict major cardiac events in type 2 diabetic patients (p) without previous cardiac symptoms Methods Observational and prospective study in diabetic patients without symptoms suggestive of coronary heart disease (CHD), derived from performing a CT in the previous 5 years, for different reasons, not related to acute coronary syndrome. The presence of CHD was analyzed, as well as the incidence for cardiac events during follow-up. Results 402 diabetic patients, mean evolution time of the disease: 6.8 +/- 2.1 years, mean Hb1Ac 8.1 +/- 0.7%. 60% of patients were male. Regarding other cardiovascular risk factors: 66.3% were hypertensive. 58.8% dyslipidemic. 26.3% obese. 27.5% smokers. 32.5% ex-smokers. 36.3% had a family history of CHD. Most frequent indication for CT: CHD screening, with previous inconclusive tests (26.3%), followed by pre-surgery evaluation (25%). Agatston Score 278.3 ± 235.8, Agatston Score> 400 132 (32.8%), significant CHD 174 (43.2%), Vulnerable plaques 84 (20.9%) The average follow-up was 5 years (+/- 1.3); 90 p (22.3%) suffered cardiac events (63 cardiac deaths, 27 non-fatal myocardial infarction). Best correlation with events was observed with the presence of significant coronary disease (ostruction> 50%) compared to the Agatston score and the presence of vulnerable plaques (adjusted c-index of 0.59 versus univariate c-index of 0.42, respectively) The annual event rate for patients with normal coronary arteries was 1.8%, which translated into a 5-year event-free survival period. The highest annual event rate of 22.3% was detected in patients with obstructive 3-vessel CAD Conclusions Non-invasive CT angiography allows, after quantifying plaque severity in diabetic patients, to reclassify patients at high / very high risk Diabetic patients with normal coronary arteries on CT angiography had a 5-year survival period free of major cardiac events.

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Blood urea level and diabetes duration are independently associated with ankle-brachial index in type 2 diabetic patients

Diabetes & Metabolic Syndrome Clinical Research & Reviews ◽

10.1016/j.dsx.2012.05.006 ◽

2012 ◽

Vol 6 (1) ◽

pp. 32-35

Author(s):

Marijan Bosevski ◽

Sabita S. Soedamah-Muthu

Keyword(s):

Ankle Brachial Index ◽

Diabetes Duration ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Urea Level ◽

Blood Urea Level ◽

Type 2 Diabetic

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Faktor Risiko yang Berpengaruh terhadap Terjadinya Hipertensi pada Penderita Diabetes Melitus Tipe II di Wilayah Puskesmas Kabupaten Pati

Jurnal Epidemiologi Kesehatan Komunitas ◽

10.14710/j.e.k.k.v2i2.3996 ◽

2017 ◽

Vol 2 (2) ◽

pp. 54

Author(s):

Gracilaria Puspa Sari ◽

Shofa Chasani ◽

Tjokorda Gde Dalem Pemayun ◽

Suharyo Hadisaputro ◽

Heri Nugroho

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Type 2 Diabetes ◽

Medication Adherence ◽

Coffee Consumption ◽

Diabetes Duration ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

Background: The prevalence of hypertension in type 2 diabetic patients is 1,5-3 times higher than it is in nondiabetic individuals This chronic condition accelerates macrovascular complications. Research about risk factors of hypertension in type 2 diabetic patients is still rare because its causes multifactorial. The objectives of this research is to explain the risk factors affecting hypertension in type 2 diabetic patients.Methods: An observational studies with case-control study design in Primary Healthcare Centers patients in Pati District. Patients with hypertension in type 2 diabetes are the case, while the type 2 diabetes patients without hypertension are the control. There were 57 cases and 57 controls included. Data were obtained from medical records and qualitative interviews. Chi-square test in bivariate and multiple logistic regression in multivariate analysis.Results: Factors that influence hypertension in type 2 diabetic patients were physical activity (OR=6,4; 95% CI: 2,18 - 18,77; p=0,001), diabetes duration ≥ 5 years (OR=5,4; 95% CI: 1,97 - 14,704; p=0,001), and medication adherence (OR=3,6; 95% CI: 1,32 - 9,83; p=0,012). Other risk factors i.e age ≥45 years, male, diet compliance, history of hypertension, smoking, salt consumption, coffee consumption, and sleep duration were not significantly influenced.Conclusion: In this study, physical activity, diabetes duration, and DM medication adherence are risk factors that influence of hypertension in type 2 diabetic patients.

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