Infant Leukaemia and Maternal Exposures during Pregnancy

2014 ◽  
Vol 2014 (1) ◽  
pp. 2730
Author(s):  
Ludwine Castelyn* ◽  
karel van damme
Keyword(s):  
Maternal Exposures ◽  
Exposures During Pregnancy

scholarly journals A systematic review of associations between maternal exposures during pregnancy other than smoking and antenatal fetal measurements

2019 ◽  
Vol 173 ◽  
pp. 528-538 ◽  
Author(s):  
Ivory Huang ◽  
Diane Mak ◽  
Prudence Cheung ◽  
Miriam Abraham ◽  
Tom Clemens ◽  
...  
Keyword(s):  
Systematic Review ◽  
Maternal Exposures ◽  
Exposures During Pregnancy

scholarly journals Genome-wide interaction study implicates VGLL2 and alcohol exposure and PRL and smoking in orofacial cleft risk

2020 ◽  
Author(s):  
Jenna C. Carlson ◽  
John R. Shaffer ◽  
Fred Deleyiannis ◽  
Jacqueline T. Hecht ◽  
George L. Wehby ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Alcohol Exposure ◽  
Behavioral Changes ◽  
Interaction Study ◽  
Stage Design ◽  
Risk Variants ◽  
Genome Wide ◽  
A Genome ◽  
Maternal Exposures ◽  
Exposures During Pregnancy

ABSTRACTNon-syndromic cleft lip with or without cleft palate (NSCL/P) is a common birth defect, affecting approximately 1 in 700 births. NSCL/P has complex etiology including several known genes and environmental factors; however, known genetic risk variants only account for a small fraction of the heritability of NSCL/P. It is commonly suggested that gene-by-environment (G×E) interactions may help explain some of the “missing” heritability of NSCL/P. We conducted a genome-wide G×E interaction study in European cases and controls with three common maternal exposures during pregnancy: alcohol, smoking, and vitamin use using a two-stage design. After selecting 127 loci with suggestive 2df tests for gene and G x E effects, 40 loci showed significant G x E effects after correcting for multiple tests. Notable interactions included SNPs of 6q22 near VGLL2 with alcohol and 6p22.3 near PRL with smoking. These interactions could provide new insights into the etiology of CL/P and new opportunities to modify risk through behavioral changes.

Adverse maternal exposures, methylation of glucocorticoid-related genes and perinatal outcomes: a systematic review

Epigenomics ◽  
2016 ◽  
Vol 8 (7) ◽  
pp. 925-944 ◽  
Author(s):  
Sairaman Nagarajan ◽  
Bobak Seddighzadeh ◽  
Andrea Baccarelli ◽  
Lauren A Wise ◽  
Michelle Williams ◽  
...  
Keyword(s):  
Systematic Review ◽  
Perinatal Outcomes ◽  
Maternal Exposures

scholarly journals Chemical Mixture Exposures during Pregnancy and Cognitive Abilities in School-Aged Children

2019 ◽  
Vol 3 ◽  
pp. 190
Author(s):  
Kalloo G ◽  
Wellenius G ◽  
McCandless L ◽  
Calafat A ◽  
Sjodin A ◽  
...  
Keyword(s):  
Cognitive Abilities ◽  
Chemical Mixture ◽  
School Aged Children ◽  
Exposures During Pregnancy

Congenital cardiac anomalies relative to selected maternal exposures and conditions during early pregnancy

1992 ◽  
Vol 8 (5) ◽  
pp. 757-760 ◽  
Author(s):  
G. M. Shaw ◽  
L. H. Malcoe ◽  
S. H. Swan ◽  
S. K. Cummins ◽  
J. Schulman
Keyword(s):  
Early Pregnancy ◽  
Cardiac Anomalies ◽  
Congenital Cardiac Anomalies ◽  
Maternal Exposures

Nutrition and Lifestyle for Pregnancy and Breastfeeding

2015 ◽  
Author(s):  
Peter Gluckman ◽  
Mark Hanson ◽  
Chong Yap Seng ◽  
Anne Bardsley
Keyword(s):  
Birth Outcomes ◽  
Health Care Providers ◽  
Care Providers ◽  
Foetal Development ◽  
Online Resource ◽  
Lifestyle Choices ◽  
Exposures During Pregnancy ◽  
The Impact ◽  
Diet Behaviour ◽  
Practical Implications

Explaining the practical implications of new discoveries in 'life-course biology', Nutrition and Lifestyle for Pregnancy and Breastfeeding is an informed resource on factors that affect offspring development. The impact of parental lifestyle and behavioural choices influence not only foetal development and birth outcomes, but also postnatal development, yet guidance on appropriate diet, behaviour, and exposures during pregnancy is often confusing and contradictory. With accessible explanations of the latest scientific research, and clear summaries and recommendations, this online resource is a valuable and authoritative guide for all levels of health care providers. It provides an overview of the background evidence, highlighting the importance of lifestyle choices prior to and during pregnancy, and it includes in-depth discussions of nutritional and lifestyle factors that impact on pregnancy and offspring that are based on the latest research and exploration of key scientific studies.

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