Behçet’s Disease and Tuberculosis: A Complex Relationship

Behçet’s disease (BD) is a systemic vasculitis characterized by recurrent orogenital ulceration and several systemic manifestations (such as gastrointestinal involvement, vascular disease or arthritis). The pathogenesis is still unknown but the trigger role of certain pathogens such as Mycobacterium tuberculosis is well documented. Furthermore, patients with BD are more susceptible to tuberculosis due to immunity defects. Here, we describe the case of a 70-year-old woman with a history of recurrent oral aphthae and inflammatory arthritis presenting with extensive thrombosis of left upper limb major veins, a positive HLA B51 genotype and colon ulceration; hence, BD diagnosis was made after excluding other causes. Simultaneously, the patient had cutaneous abscesses not associated with immunosuppressive therapy with continuous development, and after recurrent negative tuberculosis work-up, M. tuberculosis was isolated in an abscess culture.

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Behcet's Disease and Endocrine System

Pathology Research International ◽

10.1155/2012/827815 ◽

2012 ◽

Vol 2012 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Onur Ozhan ◽

Kerem Sezer

Keyword(s):

Insulin Resistance ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Systemic Vasculitis ◽

Endocrine System ◽

The Body ◽

Behcet's Disease ◽

Systemic Manifestations ◽

Anterior Hypophysis

Behcet's disease (BD) is a chronic disease which is characterized by recurrent oral apthous ulcerations, recurrent genital ulcerations, skin eruptions, ocular involvements and other various systemic manifestations as well as systemic vasculitis. Endocrine involvement in BD regarding various systems can be seen. Hypophysis is one of the best and dense vascularized organs of the body, thus it is likely that it can be affected by BD. Not only anterior hypophysis functions, but posterior hypophysis functions as well can be affected. As BD is a disease of autoimmune process, it may be possible that adrenal insufficiency or alterations in the cortisol levels could be expected. Another concern is whether or not there is insulin resistance in patients with BD. The avaliable data suggests that there is an increased susceptibility to insulin resistance in patients with BD.

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Response to: ‘Correspondence on ‘Critical role of neutrophil extracellular traps (NETs) in patients with Behcet’s disease’’ by Chen et al

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-219484 ◽

2020 ◽

pp. annrheumdis-2020-219484

Author(s):

Alexandre Le Joncour ◽

David Saadoun ◽

Yacine Boulaftali

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Critical Role ◽

Neutrophil Extracellular Traps ◽

Behcet's Disease ◽

Extracellular Traps

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Role of miR-146a rs2910164 and UTS2 rs228648 Genetic Variants in Behçet’s Disease

Immunological Investigations ◽

10.1080/08820139.2021.1883647 ◽

2021 ◽

pp. 1-10

Author(s):

Asmaa Kamal ◽

Fatema T Elgengehy ◽

Zahraa Elawady ◽

Nahla A. Fawzy ◽

Ola El Sisi

Keyword(s):

Behçet’S Disease ◽

Genetic Variants ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Behcet's Disease

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French recommendations for the management of Behçet’s disease

Orphanet Journal of Rare Diseases ◽

10.1186/s13023-020-01620-4 ◽

2021 ◽

Vol 16 (S1) ◽

Author(s):

Isabelle Kone-Paut ◽

◽

Stéphane Barete ◽

Bahram Bodaghi ◽

Kumaran Deiva ◽

...

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Initial Assessment ◽

Diagnostic Process ◽

Behcet's Disease ◽

Therapeutic Modalities ◽

Clinical Presentations ◽

Key Points

AbstractBehçet’s disease (BD) is a systemic variable vessel vasculitis that involves the skin, mucosa, joints, eyes, arteries, veins, nervous system and gastrointestinal system, presenting with remissions and exacerbations. It is a multifactorial disease, and several triggering factors including oral cavity infections and viruses may induce inflammatory attacks in genetically susceptible individuals. BD vasculitis involves different vessel types and sizes of the vascular tree with mixed-cellular perivascular infiltrates and is often complicated by recurrent thrombosis, particularly in the venous compartment. Several new therapeutic modalities with different mechanisms of action have been studied in patients with BD. A substantial amount of new data have been published on the management of BD, especially with biologics, over the last years. These important therapeutic advances in BD have led us to propose French recommendations for the management of Behçet’s disease [Protocole National de Diagnostic et de Soins de la maladie de Behçet (PNDS)]. These recommendations are divided into two parts: (1) the diagnostic process and initial assessment; (2) the therapeutic management. Thirty key points summarize the essence of the recommendations. We highlighted the main differential diagnosis of BD according to the type of clinical involvement; the role of genetics is also discussed, and we indicate the clinical presentations that must lead to the search for a genetic cause.

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Old and New Challenges in Uveitis Associated with Behçet’s Disease

Journal of Clinical Medicine ◽

10.3390/jcm10112318 ◽

2021 ◽

Vol 10 (11) ◽

pp. 2318

Author(s):

Julie Gueudry ◽

Mathilde Leclercq ◽

David Saadoun ◽

Bahram Bodaghi

Keyword(s):

Behçet’S Disease ◽

Structural Damage ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Systemic Vasculitis ◽

Retinal Vasculitis ◽

Unknown Origin ◽

Current Data ◽

Ocular Involvement ◽

Behcet's Disease

Behçet’s disease (BD) is a systemic vasculitis disease of unknown origin occurring in young people, which can be venous, arterial or both, classically occlusive. Ocular involvement is particularly frequent and severe; vascular occlusion secondary to retinal vasculitis may lead to rapid and severe loss of vision. Biologics have transformed the management of intraocular inflammation. However, the diagnosis of BD is still a major challenge. In the absence of a reliable biological marker, diagnosis is based on clinical diagnostic criteria and may be delayed after the appearance of the onset sign. However, therapeutic management of BD needs to be introduced early in order to control inflammation, to preserve visual function and to limit irreversible structural damage. The aim of this review is to provide current data on how innovations in clinical evaluation, investigations and treatments were able to improve the prognosis of uveitis associated with BD.

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