scholarly journals Recurrence of Graves’ Disease (a Th1-type Cytokine Disease) Following SARS-CoV-2 mRNA Vaccine Administration: A Simple Coincidence?

2021 ◽  
Author(s):  
Guillaume Pierman ◽  
Etienne Delgrange ◽  
Corinne Jonas
Keyword(s):  
Immune Response ◽  
Interferon Gamma ◽  
Young Women ◽  
Systematic Study ◽  
Tsh Receptor ◽  
Graves Disease ◽  
Immune Disease ◽  
Vaccine Administration ◽  
Class 1 ◽  
Th1 Immune Response

Graves’ disease is the most frequent cause of hyperthyroidism in young women. This auto-immune disease is due to the production of class 1 IgG stimulating the TSH receptor. These antibodies are produced secondary to a Th1 immune response in which interferon gamma plays a key role. Vaccination is ongoing worldwide against SARS-CoV-2 and some of the vaccines include mRNA which seems to stimulate the Th1 immune response. Here, we report a case of recurrence of hyperthyroidism due to Graves’ disease following mRNA vaccination and discuss the possible implicated mechanism. This observation argues for a systematic study of a population of patients with previous Graves’ disease in order to assess the risk of recurrence following vaccination.

scholarly journals Induction of Interferon-Gamma (IFN-γ) and T Helper 1 (Th1) Immune Response by Bitter Gourd Extract

2005 ◽  
Vol 67 (5) ◽  
pp. 521-524 ◽  
Author(s):  
Kazunori IKE ◽  
Yuko UCHIDA ◽  
Tomohiko NAKAMURA ◽  
Soichi IMAI
Keyword(s):  
Immune Response ◽  
Interferon Gamma ◽  
Bitter Gourd ◽  
T Helper ◽  
T Helper 1 ◽  
Ifn Gamma ◽  
Th1 Immune Response

Interferon-gamma ELISPOT detecting reactivity of T cells to TSH receptor peptides in Graves' disease

2013 ◽  
Vol 80 (2) ◽  
pp. 296-300 ◽  
Author(s):  
Sarah Côté-Bigras ◽  
Audrey Dionne ◽  
Patrick Asselin-Mullen ◽  
Coralie Leblicq ◽  
Diane Rottembourg
Keyword(s):  
T Cells ◽  
Interferon Gamma ◽  
Tsh Receptor ◽  
Graves Disease

Relevance of TSH-Receptor stimulating and blocking autoantibody measurement for the prediction of relapse in Graves' disease

2005 ◽  
Vol 113 (S 1) ◽  
Author(s):  
M Schott ◽  
WB Minich ◽  
C Papewalis ◽  
J Seissler ◽  
WA Scherbaum ◽  
...  
Keyword(s):  
Tsh Receptor ◽  
Graves Disease ◽  
Prediction Of Relapse

Anti-thyrotrophin receptor antibodies in Graves' disease as demonstrated directly by immunoprecipitation assay

1983 ◽  
Vol 102 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Tjerk W. A de Bruin ◽  
Daan van der Heide ◽  
Maria C. Krol
Keyword(s):  
Binding Site ◽  
Tsh Receptor ◽  
Graves Disease ◽  
Immunoprecipitation Assay ◽  
Receptor Complexes ◽  
Auto Antibody ◽  
Receptor Antibodies ◽  
Normal Controls

Abstract. An immunoprecipitation assay was developed to determine the presence of antibodies against human TSH1 receptors. With this assay we were able to demonstrate that in comparison with sera from normal controls, 24 out of 30 (80%) sera from patients with untreated Graves' disease could immunoprecipitate more [125I]TSH-TSH receptor complexes. In 9 assays, an average of 14.1 ± 3.7% (sd) of the [125I]TSH-TSH receptor complexes was immunoprecipitated by the 30 Graves' sera vs 9.8 ± 3.0% by the normal pool serum (n = 23) (P < 0.001) and 7.7 ± 2.8% by the 22 normal sera (P < 0.001). One serum of the 24 positive Graves' sera was studied in detail. The results suggest that this serum contained an anti-TSH receptor auto-antibody directed towards a different determinant on the TSH receptor than the TSH binding site.

Biological Underpinnings of Health Alterations in Women With PTSD: A Sex Disparity

2005 ◽  
Vol 7 (1) ◽  
pp. 44-54 ◽  
Author(s):  
Jessica M. Gill ◽  
Sarah L. Szanton ◽  
Gayle G. Page
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Immune Response ◽  
Major Depressive Disorder ◽  
Stress Disorder ◽  
Neuroendocrine System ◽  
Major Depressive ◽  
Fourfold Increase ◽  
Sex Disparity ◽  
Th1 Immune Response

Women develop posttraumatic stress disorder (PTSD) at twice the rate of men, even though fewer women than men experience traumatic events over their lifetimes. Current studies of individuals with PTSD provide evidence of alterations in the neuroendocrine system that involve levels and activity of cortisol and DHEA and changes in immune function that predispose these individuals toward an innate (Th1) immune response. Yet few studies have addressed the possible role of these biologic alterations in women’s increased vulnerability to developing PTSD. In addition, current studies are limited in their ability to link biologic alterations to the observed fourfold increase in medical conditions in women with PTSD as compared to women without PTSD. And finally, few studies have addressed the biologic impact of co-occurring major depressive disorder (MDD) in individuals with PTSD. This critical review provides an update on neuroendocrine and immune perturbations associated with PTSD with and without cooccurring MDD to suggest links to health and possible mechanisms underlying the observed sex disparity in the development of PTSD.

scholarly journals Determinants of Extraocular Muscle Volume in Patients with Graves' Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Samer El-Kaissi ◽  
Jack R. Wall
Keyword(s):  
Extraocular Muscle ◽  
Tsh Receptor ◽  
Graves Disease ◽  
Thyroid Function Tests ◽  
Thyroid Scintigraphy ◽  
Free T4 ◽  
Receptor Antibody ◽  
Tsh Receptor Antibody ◽  
Antibody Positivity ◽  
Serum Tsh

Background. To examine factors contributing to extraocular muscle (EOM) volume enlargement in patients with Graves’ hyperthyroidism.Methods. EOM volumes were measured with orbital magnetic resonance imaging (MRI) in 39 patients with recently diagnosed Graves’ disease, and compared to EOM volumes of 13 normal volunteers. Thyroid function tests, uptake on thyroid scintigraphy, anti-TSH-receptor antibody positivity and other parameters were then evaluated in patients with EOM enlargement.Results. 31/39 patients had one or more enlarged EOM, of whom only 2 patients had clinical EOM dysfunction. Compared to Graves’ disease patients with normal EOM volumes, those with EOM enlargement had significantly higher mean serum TSH (0.020±0.005versus0.007±0.002mIU/L;Pvalue 0.012), free-T4 (52.9±3.3versus41.2±1.7 pmol/L;Pvalue 0.003) and technetium uptake on thyroid scintigraphy (13.51±1.7%versus8.55±1.6%;Pvalue 0.045). There were no differences between the 2 groups in anti-TSH-receptor antibody positivity, the proportion of males, tobacco smokers, or those with active ophthalmopathy.Conclusions. Patients with recently diagnosed Graves’ disease and EOM volume enlargement have higher serum TSH and more severe hyperthyroidism than patients with normal EOM volumes, with no difference in anti-TSH-receptor antibody positivity between the two groups.

Whither TSH Receptor Blocking Antibodies in the Treatment of Graves' Disease?

Thyroid ◽  
2008 ◽  
Vol 18 (7) ◽  
pp. 695-696 ◽  
Author(s):  
Basil Rapoport ◽  
Sandra M. McLachlan
Keyword(s):  
Tsh Receptor ◽  
Graves Disease ◽  
Receptor Blocking ◽  
Blocking Antibodies
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