What does remain a growing concern for many users of Data Centers is their continuing availability following the explosive growth of internet services in recent years, The recent maximizing of Data Center IT virtualization investments has resulted in improving the consolidation of prior (under utilized) server and cabling resources resulting in higher overall facility utilization and IT capacity. It has also resulted in excessive levels of equipment heat release, e.g. high energy (i.e. blade type) servers and telecommunication equipment, that challenge central and distributed air conditioning systems delivering air via raised floor or overhead to rack mounted servers arranged in alternate facing cold and hot isles (in some cases reaching 30 kW/rack or 300 W/ft2) and returning via end of isle or separated room CRAC units, which are often found to fight each other, contributing to excessive energy use. Under those circumstances, hybrid, indirect liquid cooling facilities are often required to augment above referenced air conditioning systems in order to prevent overheating and degradation of mission critical IT equipment to maintain rack mounted subject rack mounted server equipment to continue to operate available within ASHRAE TC 9.9 prescribed task psychometric limits and IT manufacturers specifications, beyond which their operational reliability cannot be assured. Recent interest in new web-based software and secure cloud computing is expected to further accelerate the growth of Data Centers which according to a recent study, the estimated number of U.S. Data Centers in 2006 consumed approximately 61 billion kWh of electricity. Computer servers and supporting power infrastructure for the Internet are estimated to represent 1.5% of all electricity generated which along with aggregated IT and communications, including PC’s in current use have also been estimated to emit 2% of global carbon emissions. Therefore the projected eco-footprint of Data Centers into the future has now become a matter of growing concern. Accordingly our paper will focus on how best to improve the energy utilization of fossil fuels that are used to power Data Centers, the energy efficiency of related auxiliary cooling and power infrastructures, so as to reduce their eco-footprint and GHG emissions to sustainable levels as soon as possible. To this end, we plan to demonstrate significant comparative savings in annual energy use and reduction in associated annual GHG emissions by employing a on-site cogeneration system (in lieu of current reliance on remote electric power generation systems), introducing use of energy efficient outside air (OSA) desiccant assisted pre-conditioners to maintain either Class1, Class 2 and NEBS indoor air dew-points, as needed, when operated with modified existing (sensible only cooling and distributed air conditioning and chiller systems) thereby eliminating need for CRAC integral unit humidity controls while achieving a estimated 60 to 80% (virtualized) reduction in the number servers within a existing (hypothetical post-consolidation) 3.5 MW demand Data Center located in southeastern (and/or southern) U.S., coastal Puerto Rico, or Brazil characterized by three (3) representative microclimates ranging from moderate to high seasonal outside air (OSA) coincident design humidity and temperature.