507 Reaction time difference between species of blood coagulation factors under a uniform shear flow field

2015 ◽  
Vol 2015.23 (0) ◽  
pp. 41-42
Author(s):  
Koki KAWAKAMI ◽  
Daisuke SAKOTA ◽  
Ryo KOSAKA ◽  
Masahiro NISHIDA ◽  
Yasuo KAWAGUCHI ◽  
...  
Keyword(s):  
Reaction Time ◽  
Shear Flow ◽  
Flow Field ◽  
Blood Coagulation ◽  
Coagulation Factors ◽  
Time Difference ◽  
Reaction Time Difference ◽  
Blood Coagulation Factors ◽  
Uniform Shear ◽  
Uniform Shear Flow

Natural Oestrogen in the Female Climacteric - Influence on Blood Coagulation and Fibrinolysis

1978 ◽  
Vol 40 (02) ◽  
pp. 532-541 ◽  
Author(s):  
Anders Lagrelius ◽  
Nils-Olov Lunell ◽  
Margareta Blombäck
Keyword(s):  
Blood Coagulation ◽  
Antithrombin Iii ◽  
Coagulation Factors ◽  
Control Group ◽  
Blood Coagulation Factors ◽  
Excessive Bleeding ◽  
Oestrone Sulphate ◽  
Menopausal Women ◽  
History Of ◽  
Coagulation And Fibrinolysis

SummaryThe aim of the present study was to investigate the effect on blood coagulation and fibrinolysis of a natural oestrogen preparation, piperazine oestrone sulphate, prospectively in menopausal women. Scopolamine was given to the control group.The women were investigated before and during treatment with regard to factors VIII, VII, X, V, fibrinopeptide A, antithrombin III, plasminogen, rapid antiplasmin and α1-antitrypsin. There was no significant change towards hypercoagulability or decreased fibrinolysis in any group. In the oestrogen group, however, a tendency towards an increased level of plasminogen and a decreased level of antiplasmin was demonstrated. In the scopolamine group there was an unexpected fall in factors X and V and also in plasminogen and α1,-antitrypsin. A low level of some blood coagulation factors in some of the women before treatment is somewhat astonishing; none of them had any history of excessive bleeding.

STEROIDSTRUKTUR UND LEBERTOXIZITÄT

1967 ◽  
Vol 54 (1) ◽  
pp. 73-84 ◽  
Author(s):  
H. L. Krüskemper ◽  
G. Noell
Keyword(s):  
Alkaline Phosphatase ◽  
Liver Function ◽  
Blood Coagulation ◽  
Electrophoretic Pattern ◽  
Coagulation Factors ◽  
Blood Coagulation Factors ◽  
Methyl Group ◽  
Liver Functions ◽  
Male Subjects ◽  
Androstane Derivatives

ABSTRACT In male subjects investigations have been carried out regarding the effect of C1- and C17-methylated androstane derivatives (20 mg per day, orally, two weeks) on liver functions (parameters: activities of GPT, GOT, alkaline phosphatase and cholinesterase in serum; electrophoretic pattern; blood coagulation factors V, VII, X and prothrombin; BSP-retention). In addition to the well known hepatotropic action of 17α-alkylated C-19-steroids a quasi-axial 1α-methyl configuration (in 1α-methylandrost-2-en-17β-ol) definitely increased BSP-retention and several coagulation factors. These steroid effects decreased gradually when a methyl group was introduced in C1 equatorially (1-methylandrost-1-en-17β-ol-3-one) or quasi-equatorially (1β-methylandrost-2-en-17β-ol), the latter compound completely lacking from any influence on parameters of liver function under investigation.

EXPRESSION IN ONTOGENESIS OF HUMAN BLOOD COAGULATION FACTORS

1987 ◽  
Author(s):  
H J Hassan ◽  
A Leonardi ◽  
C Chelucci ◽  
R Guerriero ◽  
P M Mannucci ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Protein C ◽  
Antithrombin Iii ◽  
Liver Homogenate ◽  
Coagulation Factor ◽  
Coagulation Factors ◽  
Factor Ix ◽  
Adult Liver ◽  
Blood Coagulation Factors ◽  
Guanidine Isothiocyanate

We have analyzed the expression of several blood coagulation factors (IX, VIII, X, fibrinogen chains) and inhibitors (antithrombin III, protein C) in human embryonic and fetal livers, obtained from legal abortions at 6-11 week post-conception. The age was established by morphologic staging and particularly crown-rump lenght measurement.Total cellular RNA was isolated from partially purified hepatocytes or total liver homogenate using the guanidine isothiocyanate method. Poly(A)+ RNA was selected by oligodT cellulose chromatography. The size and the number of the embryonic and fetal transcripts are equivalent to those observed in adult liver, as evaluated by Northern blot analysis of total or poly(A)+ RNA hybridized to human cDNA probes.The level of coagulation factor transcripts in embryonic and fetal liver was evaluated by dot hybridization of total RNA (0.5-10 ug), as compared to RNA extracted from normal adult liver biopsies. The expression of blood coagulation factors in embryos is generally reduced for all factors, but at a different degree. In 5-11 wk liver, the level of factor IX is 5-10% of that observed in adults, while fibrinogen, protein C, antithrombin III RNA level rises from 25 to 50% and factor X is expressed at a level comparable to that observed in adult liver.We conclude that during these stages of development blood coagulation factors are expressed according to three different time, curves, possibly due to the effect of different types of regulatory mechanisms.

Formation of Vortex Street in Laminar Boundary Layer

1980 ◽  
Vol 47 (2) ◽  
pp. 227-233 ◽  
Author(s):  
M. Kiya ◽  
M. Arie
Keyword(s):  
Boundary Layer ◽  
Shear Flow ◽  
Laminar Boundary Layer ◽  
Solid Wall ◽  
Vortex Sheet ◽  
Vortex Street ◽  
Bluff Bodies ◽  
Uniform Shear ◽  
Uniform Shear Flow ◽  
Vortex Patterns

Main features of the formation of vortex street from free shear layers emanating from two-dimensional bluff bodies placed in uniform shear flow which is a model of a laminar boundary layer along a solid wall. This problem is concerned with the mechanism governing transition induced by small bluff bodies suspended in a laminar boundary layer. Calculations show that the background vorticity of shear flow promotes the rolling up of the vortex sheet of the same sign whereas it decelerates that of the vortex sheet of the opposite sign. The steady configuration of the conventional Karman vortex street is not possible in shear flow. Theoretical vortex patterns are experimentally examined by a flow-visualization technique.

Phenindione and Blood-coagulation Factors

BMJ ◽  
1961 ◽  
Vol 1 (5242) ◽  
pp. 1831-1831
Author(s):  
F. Nour-Eldin
Keyword(s):  
Blood Coagulation ◽  
Coagulation Factors ◽  
Blood Coagulation Factors

The formation mechanism and shedding frequency of vortices from a sphere in uniform shear flow

1995 ◽  
Vol 287 ◽  
pp. 151-171 ◽  
Author(s):  
Hiroshi Sakamoto ◽  
Hiroyuki Haniu
Keyword(s):  
Reynolds Number ◽  
Shear Flow ◽  
Formation Mechanism ◽  
Vortex Shedding ◽  
Uniform Flow ◽  
Sphere Diameter ◽  
Uniform Shear ◽  
Uniform Shear Flow ◽  
Vortex Loops ◽  
Shear Parameter

Experiments to investigate the formation mechanism and frequency of vortex shedding from a sphere in uniform shear flow were conducted in a water channel using flow visualization and velocity measurement. The Reynolds number, defined in terms of the sphere diameter and approach velocity at its centre, ranged from 200 to 3000. The shear parameter K, defined as the transverse velocity gradient of the shear flow non-dimensionalized by the above two parameters, was varied from 0 to 0.25. The critical Reynolds number beyond which vortex shedding from the sphere occurred was found to be lower than that for uniform flow and decreased approximately linearly with increasing shear parameter. Also, the Strouhal number of the hairpin-shaped vortex loops became larger than that for uniform flow and increased as the shear parameter increased.The formation mechanism and the structure of vortex shedding were examined on the basis of series of photographs and subsequent image processing using computer graphics. The range of Reynolds number in the present investigation, extending up to 3000, could be classified into three regions on the basis of this study, and it was observed that the wake configuration did not differ substantially from that for uniform flow. Also, unlike the detachment point of vortex loops in uniform flow, which was irregularly located along the circumference of the sphere, the detachment point in shear flow was always on the high-velocity side.

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