Research on Microfluidic Chip for High-throughput Gene Transfer into Cells by Electrically-induced Bubbles

2020 ◽  
Vol 2020 (0) ◽  
pp. 1A1-N13
Author(s):  
Taiga Michimoto ◽  
Kevin Theodric Uning ◽  
Keita Ichikawa ◽  
Yoko Yamanishi
Keyword(s):  
Gene Transfer ◽  
High Throughput ◽  
Microfluidic Chip

scholarly journals Identification of novel small molecule inhibitors of adenovirus gene transfer using a high throughput screening approach

2013 ◽  
Vol 170 (1) ◽  
pp. 132-140 ◽  
Author(s):  
Margaret R. Duffy ◽  
Alan L. Parker ◽  
Eric R. Kalkman ◽  
Katie White ◽  
Dmytro Kovalskyy ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Small Molecule ◽  
High Throughput ◽  
High Throughput Screening ◽  
Small Molecule Inhibitors ◽  
Screening Approach

Microfluidic Combinatorial Screening Platform

2012 ◽  
Author(s):  
Helena Zec ◽  
Tushar D. Rane ◽  
Wen-Chy Chu ◽  
Tza-Huei Wang
Keyword(s):  
High Throughput ◽  
Microfluidic Chip ◽  
Linear Array ◽  
Large Array ◽  
Snp Detection ◽  
Combinatorial Screening ◽  
Biological Assays ◽  
Reagent Consumption ◽  
Daughter Droplets ◽  
Screening Platform

We propose a microfluidic droplet-based platform that accepts an unlimited number of sample plugs from a multi-well plate, performs splitting of these sample droplets into smaller daughter droplets and subsequent synchronization-free, reliable fusion of sample daughter droplets with multiple reagents simultaneously. This system consists of two components: 1) a custom autosampler which generates a linear array of sub-microliter plugs in a microcapillary from a multi-well plate and 2) A microfluidic chip with channels for sample plug introduction, reagent merging and droplet incubation. This novel system generates large arrays of heterogeneous droplets from hundreds to thousands of samples while concurrently screening these arrays against a large array of reagents. This high throughput system minimizes sample and reagent consumption and can be applied to a gamut of biological assays, ranging from SNP detection to forensic screening.

Drug effects analysis on cells using a high throughput microfluidic chip

2010 ◽  
Vol 13 (1) ◽  
pp. 215-219 ◽  
Author(s):  
Zhongcheng Gong ◽  
Hong Zhao ◽  
Tianhua Zhang ◽  
Fang Nie ◽  
Pushparaj Pathak ◽  
...  
Keyword(s):  
High Throughput ◽  
Microfluidic Chip ◽  
Drug Effects

A high-throughput microfluidic chip for size sorting of cells

2011 ◽  
Author(s):  
Xuebin Tan ◽  
Hyeun-Joong Yoon ◽  
James Granneman ◽  
Hsiao-Ping Moore ◽  
Mark Ming-Cheng Cheng
Keyword(s):  
High Throughput ◽  
Microfluidic Chip ◽  
Size Sorting

Rational design of a turn-on fluorescent sensor for α-ketoglutaric acid in a microfluidic chip

2014 ◽  
Vol 5 (10) ◽  
pp. 4012-4016 ◽  
Author(s):  
Pengwei Jin ◽  
Changhong Jiao ◽  
Zhiqian Guo ◽  
Ye He ◽  
Shiqin Zhu ◽  
...  
Keyword(s):  
High Throughput ◽  
Microfluidic Chip ◽  
High Throughput Screening ◽  
Rational Design ◽  
Fluorescent Sensor ◽  
Fluorescent Chemosensors ◽  
Turn On

A rational design of turn-on fluorescent chemosensors for monitoring α-ketoglutaric acid has been developed with a microfluidic chip, indicative of a potential platform for high-throughput screening and monitoring of kinetics, especially in biological fields.

scholarly journals Mutation Scanning Using MUT-MAP, a High-Throughput, Microfluidic Chip-Based, Multi-Analyte Panel

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e51153 ◽  
Author(s):  
Rajesh Patel ◽  
Alison Tsan ◽  
Rachel Tam ◽  
Rupal Desai ◽  
Nancy Schoenbrunner ◽  
...  
Keyword(s):  
High Throughput ◽  
Microfluidic Chip ◽  
Mutation Scanning
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