scholarly journals Distribution of Virulence Factors and Antimicrobial Resistance Properties of Uropathogenic Escherichia coli Isolated from Diabetic and Healthy Males Suffered from Urinary Tract Infections

2016 ◽  
Vol 13 (2) ◽  
pp. 931-937
Author(s):  
Reza Rezaee ◽  
Amir Talebreza ◽  
Katayoun Ziari ◽  
Vahid Behnod ◽  
Bibi Fatemeh Shakhs Emampour
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Virulence Factors ◽  
Urinary Tract Infections ◽  
Uropathogenic Escherichia Coli ◽  
Tract Infections ◽  
Healthy Males

scholarly journals Virulence factors of uropathogenic Escherichia coli of urinary tract infections and asymptomatic bacteriuria in children

2014 ◽  
Vol 47 (6) ◽  
pp. 455-461 ◽  
Author(s):  
Ki Wook Yun ◽  
Hak Young Kim ◽  
Hee Kuk Park ◽  
Wonyong Kim ◽  
In Seok Lim
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Virulence Factors ◽  
Urinary Tract Infections ◽  
Asymptomatic Bacteriuria ◽  
Uropathogenic Escherichia Coli ◽  
Tract Infections

scholarly journals Virulence factors and antimicrobial resistance of uropathogenic Escherichia coli (UPEC) isolated from urinary tract infections: A systematic review and meta-analysis

2021 ◽  
Author(s):  
Gabriel Kambale Bunduki ◽  
Eva Heinz ◽  
Vincent Samuel Phiri ◽  
Patrick Noah ◽  
Nicholas Feasey ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Systematic Review ◽  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Virulence Factors ◽  
Urinary Tract Infections ◽  
Meta Analysis ◽  
Analysis Model ◽  
Beta Lactams ◽  
Tract Infections

Abstract Background Uropathogenic Escherichia coli (UPEC) are amongst the most frequent causes of urinary tract infections. We report a systematic review and meta-analysis of virulence factors and antimicrobial resistance of UPEC isolated from urinary tract infections. Methods A systematic review and meta-analysis were performed using PRISMA guidelines (Research Registry ref 5874). Data were extracted from PubMed/MEDLINE and ScienceDirect databases for studies published from January 1, 2000 to December 31, 2019. Studies reporting antimicrobial resistance and virulence factors of UPEC isolated in confirmed urinary tract infections (≥ 105CFU/ml) were eligible. Prevalence of antimicrobial resistance and virulence factors of UPEC were estimated using random-effects meta-analysis model. Estimates with 95% confidence intervals, I-square (I2) statistic, and Cochran’s Q test were computed using the score statistic and the exact binomial method by incorporating the Freeman-Tukey double arcsine transformation of proportions. Results Our search returned 2,504 hits, of which 13 studies were included in the meta-analysis, totalling 1,888 UPEC isolates. Highest antimicrobial resistance rates were observed among the antibiotic class of tetracycline in 69.1% (498/721), followed by sulphonamides in 59.3% (1119/1888), quinolones in 49.4% (1956/3956), and beta-lactams in 36.9% (4410/11964). Among beta-lactams, high resistance was observed in aminopenicillins in 74.3% (1157/1557) and first generation cephalosporins in 38.8% (370/953). Meanwhile, virulence factors with highest prevalence were immune suppressors (54.1%) followed by adhesins (45.9%). Taken individually, the most observed virulence genes were shiA (92.1%), CSH (80.0%), fimH/MSHA (75.3%), traT (75.1%), sisA (72.2%), iucD (65.7%), iutA (61.8%), kpsMTII (60.6%), and PAI (55.2%). Conclusions The increased antibiotic resistance of UPEC isolates was demonstrated and suggested a need for reassessment of empirical therapies in urinary tract infections treatment caused by this pathogen. In addition, this pathotype exhibited diverse surface and secreted virulence factors.

Genetic relation and virulence factors of carbapenemase-producing Uropathogenic Escherichia coli from urinary tract infections in Iraq

Gene Reports ◽  
2020 ◽  
Vol 21 ◽  
pp. 100911
Author(s):  
Amal Talib Al-Sa'ady ◽  
Ghaidaa Jihadi Mohammad ◽  
Bashdar Mahmud Hussen
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Virulence Factors ◽  
Urinary Tract Infections ◽  
Uropathogenic Escherichia Coli ◽  
Genetic Relation ◽  
Tract Infections

scholarly journals Outcome of acute urinary tract infections caused by uropathogenic Escherichia coli with phenotypically demonstrable virulence factors

2019 ◽  
Vol 18 (3) ◽  
pp. 138 ◽  
Author(s):  
Sadia Khan ◽  
Unnimaya Pullanhi ◽  
Vivek Vinod ◽  
Karthika Mohan ◽  
Anil Kumar
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Virulence Factors ◽  
Urinary Tract Infections ◽  
Uropathogenic Escherichia Coli ◽  
Tract Infections

scholarly journals Virulence factors and antimicrobial resistance of uropathogenic Escherichia coli (UPEC) isolated from urinary tract infections: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Gabriel Kambale Bunduki ◽  
Eva Heinz ◽  
Vincent Samuel Phiri ◽  
Patrick Noah ◽  
Nicholas Feasey ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Systematic Review ◽  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Virulence Factors ◽  
Urinary Tract Infections ◽  
Meta Analysis ◽  
Analysis Model ◽  
Beta Lactams ◽  
Tract Infections

Abstract Background Uropathogenic Escherichia coli (UPEC) are amongst the most frequent causes of urinary tract infections. We report a systematic review and meta-analysis of virulence factors and antimicrobial resistance of UPEC isolated from urinary tract infections. Methods A systematic review and meta-analysis were performed using PRISMA guidelines (Research Registry ref. 5874). Data were extracted from PubMed/MEDLINE and ScienceDirect databases for studies published from January 1, 2000 to December 31, 2019. Studies reporting antimicrobial resistance and virulence factors of UPEC isolated in confirmed urinary tract infections (≥105CFU/ml) were eligible. Prevalence of antimicrobial resistance and virulence factors of UPEC were estimated using random-effects meta-analysis model. Estimates with 95% confidence intervals, I-square (I2) statistic, and Cochran’s Q test were computed using the score statistic and the exact binomial method by incorporating the Freeman-Tukey double arcsine transformation of proportions. Results Our search returned 2504 hits, of which 13 studies were included in the meta-analysis, totalling 1888 UPEC isolates. Highest antimicrobial resistance rates were observed among the antibiotic class of tetracycline in 69.1% (498/721), followed by sulphonamides in 59.3% (1119/1888), quinolones in 49.4% (1956/3956), and beta-lactams in 36.9% (4410/11964). Among beta-lactams, high resistance was observed in aminopenicillins in 74.3% (1157/1557) and first generation cephalosporins in 38.8% (370/953). Meanwhile, virulence factors with highest prevalence were immune suppressors (54.1%) followed by adhesins (45.9%). Taken individually, the most observed virulence genes were shiA (92.1%), CSH (80.0%), fimH/MSHA (75.3%), traT (75.1%), sisA (72.2%), iucD (65.7%), iutA (61.8%), kpsMTII (60.6%), and PAI (55.2%). Conclusions The increased antibiotic resistance of UPEC isolates was demonstrated and suggested a need for reassessment of empirical therapies in urinary tract infections treatment caused by this pathogen. In addition, this pathotype exhibited diverse surface and secreted virulence factors.

Molecular Analysis of Uropathogenic E.coli Isolates from Urinary Tract Infections

2019 ◽  
Vol 19 (3) ◽  
pp. 322-326 ◽  
Author(s):  
Hassan Valadbeigi ◽  
Elham Esmaeeli ◽  
Sobhan Ghafourian ◽  
Abbas Maleki ◽  
Nourkhoda Sadeghifard
Keyword(s):  
Escherichia Coli ◽  
Polymerase Chain Reaction ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Multiplex Polymerase Chain Reaction ◽  
Virulence Genes ◽  
Uropathogenic Escherichia Coli ◽  
Chain Reaction ◽  
Polymerase Chain ◽  
Tract Infections

Introduction: The aim of the current study was to investigate the prevalence of virulence genes in uropathogenic Escherichia coli (UPEC) isolates in Ilam. Materials and Methods: For this purpose, a total of 80 UPEC isolates were collected for patients with UTIs during a 6 months period. The multiplex polymerase chain reaction (multiplex PCR) was used to detect the papEF, fimH, iucD, hlyA, fyuA, and ompT genes. Results: The prevalence of fimH, papEF, iucD, fyuA, hlyA, hlyA, and ompT genes were 87.5%, 47.5%, 60%, 67.5%, 27.5%, 47.5% and 71.2%, respectively. Among all of the isolates, 27 profiles were obtained. Conclusion: Our findings demonstrated that the most prevalence was found for fimH, and different distribution of virulence genes suggested different ability of pathogenicity.

Sign in / Sign up

Export Citation Format

Share Document