scholarly journals Emulgel Approach to Formulation Development: A Review

2021 ◽  
Vol 18 (3) ◽  
pp. 459-465
Author(s):  
Brijesh Mahesh Patel ◽  
Ashwin Bhanudas Kuchekar ◽  
Saish Rajendra Pawar
Keyword(s):  
Skin Irritation ◽  
Stability Study ◽  
The Body ◽  
Systemic Effects ◽  
Dual Control ◽  
Topical Drug Delivery ◽  
Formulation Development ◽  
Irritation Test ◽  
Low Interfacial Tension ◽  
Skin Irritation Test

Topical drug delivery is the delivery of drugs anywhere in the body through skin, vaginal, ophthalmic and rectal routes. Drugs may be given for localized or systemic effects. Topical formulations with varying physicochemical properties, such as solid, semisolid, or liquid, can be developed. The topical system is created by preparing a drug emulsion and incorporating it into an emulgel. Emulgel is a thermodynamically stable formulation with low interfacial tension that is made by combining a surfactant and a co-surfactant and has several properties such as increased permeability and good thermodynamic stability. Emulgel has a dual control and a sustained release pattern. Emulgel improves bioavailability as well as patient compliance. The pH, viscosity, particle size, zeta potential, drug content, stability study, skin irritation test, and other properties of the prepared formulation are evaluated.

scholarly journals Formulation and Evaluation of Polyherbal Oil

2021 ◽  
pp. 690-697
Author(s):  
Neha N. Jagatap
Keyword(s):  
Radical Scavenging Activity ◽  
Skin Irritation ◽  
Radical Scavenging ◽  
Coconut Oil ◽  
Acid Value ◽  
Stability Study ◽  
Aloe Barbadensis ◽  
Plant Materials ◽  
Irritation Test ◽  
Skin Irritation Test

The aim of present study involves preparation of polyherbal hair oil using plant materials. The prepared polyherbal hair oil evaluated different parameters within the acceptable limits. Such as phytochemical screening, organoleptic characterization, specific gravity, pH, viscosity, acid value, saponification value, refractive index, and also stability study. Antimicrobial assay of the polyherbal hair oil was studied by the zone inhibition method. And these helps reduces dandruffs and scalp of hairs. And to provide nutrition’s of hairs. The antioxidant activity of the oil was studied by DPPH radical scavenging activity. The primary skin irritation test is carried out. Hence, these polyherbal hair oil increases hair growth, reduces hair loss, providing protection against dandruff. Now-a-days increasing demand of herbal formulation than synthetic formulation. They have better safety and also fewer side effects. Polyherbal hair oil using various fresh leaves of Hibiscus Rosa Sinesis, Aloe Barbadensis leaf, curry leaves, amla, shikekai. These formulations coconut oil as the base. Hair care products used both hair tonic as well as hair grooming aids.

scholarly journals Preparation and evaluation of poly herbal hair oil

2019 ◽  
Vol 9 (1) ◽  
pp. 68-73
Author(s):  
B. Ramya Kuber ◽  
Ch. Lavanya ◽  
Ch.Naga Haritha ◽  
S. Preethi ◽  
G. Rosa
Keyword(s):  
Skin Irritation ◽  
Radical Scavenging ◽  
Acid Value ◽  
The Body ◽  
Good Growth ◽  
Stability Studies ◽  
Irritation Test ◽  
Skin Irritation Test ◽  
Wrightia Tinctoria ◽  
Herbal Formulations

In Ayurvedic medicine, herbs are used as an integral part of health care system. Besides healthcare, herbs are also used for beautification of the body and for preparation of various cosmetics and colours. The aim of present study involves preparation of poly herbal hair oil using fresh leaves of various plants. The prepared herbal oils were subjected to phytochemical screening, General characterization, Physical and Biological evaluation.The aim of present study involves preparation of poly herbal hair oil using fresh leaves of Sphaeranthus indicus, Wrightia tinctoria, Eclipta alba, Hibiscus Rosa sinensis. The oil was prepared according to Ayurvedic pharmacopeia. The evaluation of prepared poly herbal hair oil was carried out by various parameters such as organoleptic, phytochemical, specific gravity, pH, viscosity, acid value, saponification value, refractive index and stability studies. Antimicrobial activity of the poly herbal hair oil was studied by the zone of inhibition method. The Antioxidant activity of the oil was studied by DPPH radical scavenging test. The prepared formulations are assessed for primary skin irritation test on our forearm. Above parameters were found to be good and within the standards and among three concentrations of prepared poly herbal hair oil, third concentration showed better results than other two concentrations. All the values in the evaluation of finished product showed that they are within the acceptable limits. Hence, it is concluded that the oil is beneficial in maintaining good growth of hairs, turning grey hairs to black, providing protection from dandruff, and results in lustrous looking hairs. Keywords: Hair, Herbal formulations, Hair oil, Stability studies.

scholarly journals Pre-validation of an in vitro skin irritation test for medical devices using the reconstructed human tissue model EpiDerm™

2018 ◽  
Vol 50 ◽  
pp. 407-417 ◽  
Author(s):  
Helena Kandarova ◽  
Jamin A. Willoughby ◽  
Wim H. De Jong ◽  
Silvia Letasiova ◽  
Tatiana Milasova ◽  
...  
Keyword(s):  
Medical Devices ◽  
Human Tissue ◽  
Skin Irritation ◽  
Tissue Model ◽  
Irritation Test ◽  
Skin Irritation Test

Development, optimization and standardization of an in vitro skin irritation test for medical devices using the reconstructed human tissue model epiderm

2015 ◽  
Vol 238 (2) ◽  
pp. S351-S352 ◽  
Author(s):  
H. Kandarova ◽  
J. Willoughby ◽  
W. de Jong ◽  
M. Bachelor ◽  
S. Letasiova ◽  
...  
Keyword(s):  
Medical Devices ◽  
Human Tissue ◽  
Skin Irritation ◽  
Tissue Model ◽  
Irritation Test ◽  
Skin Irritation Test

scholarly journals Formulation of tretinoin-loaded topical proniosomes for treatment of acne:in-vitrocharacterization, skin irritation test and comparative clinical study

Drug Delivery ◽  
2014 ◽  
Vol 22 (6) ◽  
pp. 731-739 ◽  
Author(s):  
Salwa Abdel Rahman ◽  
Nevine Shawky Abdelmalak ◽  
Alia Badawi ◽  
Tahany Elbayoumy ◽  
Nermeen Sabry ◽  
...  
Keyword(s):  
Clinical Study ◽  
Skin Irritation ◽  
Irritation Test ◽  
Comparative Clinical Study ◽  
Skin Irritation Test

Optimized Preparation of Capsaicin-Loaded Nanoparticles Gel by Box-Behnken Design

2014 ◽  
Vol 1061-1062 ◽  
pp. 359-368 ◽  
Author(s):  
Mei Ling Tang ◽  
Li Hua Chen ◽  
Dong Sheng Zhou ◽  
Wei Feng Zhu ◽  
Yong Mei Guan ◽  
...  
Keyword(s):  
Skin Permeation ◽  
Skin Irritation ◽  
Morphological Characteristics ◽  
Entrapment Efficiency ◽  
Box Behnken Design ◽  
Irritation Test ◽  
Predicted Values ◽  
Skin Irritation Test

A three-factor three-level Box-Behnken design(BBD) was employed to optimize capsaicin-loaded nanoparticles(Cap-NPs), and its properties in vitro and in vivo were evaluated. Particle size, morphological characteristics, entrapment efficiency of Cap-NPs were investigated respectively by Zetasizer, H7000 TEM and HPLC. Release, skin permeation and skin irritation test were investigated on mouse and rabbits. The predicted values of Cap-NPs were 94.50±6.33% for entrapment efficiency(EE) and 170.30±7.81 nm for particle mean diameter(PMD) under optimal conditions which were 346.33 bar (homogenization pressure, X1), 4.67 min(homogenization time, X2), and 15421.42 rpm (shear rate, X3). The in vitro permeation study showed that capsaicin permeability in NPs-gel was a 2.80-fold greater flux values than conventional ointment after 24 h. Cap-NPs-gel produce no observable skin irritation in rabbits within 72h. The optimized Cap-NPs-gel would be a good candidate for transdermal delivery.

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