KERNEL RECURSIVE DUAL CONTROL ALGORITHM FOR NONLINEAR DYNAMIC PROCESSES

В работе рассматривается задача адаптивной идентификации и управления нелинейными динамическими объектами. Предлагается новый рекуррентный ядерный алгоритм дуального управления с использованием идентификатора. Приводятся результаты численного исследования, подтверждающие эффективность предложенного алгоритма. The paper considers adaptive identification and control problem of nonlinear dynamic processes. For solution of the problem new recursive identification and control algorithms are proposed. The paper presents the results of a numerical study illustrating the performance of the proposed recursive identification and control algorithms.

CLAVATA3 mediated simultaneous control of transcriptional and post-translational processes provides robustness to the WUSCHEL gradient

Regulation of the homeodomain transcription factor WUSCHEL concentration is critical for stem cell homeostasis in Arabidopsis shoot apical meristems. WUSCHEL regulates the transcription of CLAVATA3 through a concentration-dependent activation-repression switch. CLAVATA3, a secreted peptide, activates receptor kinase signaling to repress WUSCHEL transcription. Considering the revised regulation, CLAVATA3 mediated repression of WUSCHEL transcription alone will lead to an unstable system. Here we show that CLAVATA3 signaling regulates nuclear-cytoplasmic partitioning of WUSCHEL to control nuclear levels and its diffusion into adjacent cells. Our work also reveals that WUSCHEL directly interacts with EXPORTINS via EAR-like domain which is also required for destabilizing WUSCHEL in the cytoplasm. We develop a combined experimental and computational modeling approach that integrates CLAVATA3-mediated transcriptional repression of WUSCHEL and post-translational control of nuclear levels with the WUSCHEL concentration-dependent regulation of CLAVATA3. We show that the dual control by the same signal forms a seamless connection between de novo WUSCHEL synthesis and sub-cellular partitioning in providing robustness to the WUSCHEL gradient.

Emulgel Approach to Formulation Development: A Review

Topical drug delivery is the delivery of drugs anywhere in the body through skin, vaginal, ophthalmic and rectal routes. Drugs may be given for localized or systemic effects. Topical formulations with varying physicochemical properties, such as solid, semisolid, or liquid, can be developed. The topical system is created by preparing a drug emulsion and incorporating it into an emulgel. Emulgel is a thermodynamically stable formulation with low interfacial tension that is made by combining a surfactant and a co-surfactant and has several properties such as increased permeability and good thermodynamic stability. Emulgel has a dual control and a sustained release pattern. Emulgel improves bioavailability as well as patient compliance. The pH, viscosity, particle size, zeta potential, drug content, stability study, skin irritation test, and other properties of the prepared formulation are evaluated.

Research and Application of Intelligent Monitoring System Platform for Safety Risk and Risk Investigation in Urban Rail Transit Engineering Construction

In recent years, the construction scale of urban rail transit project is still in a high growth stage. In addition, the geology and surrounding environment of crossing lines are complex, and all kinds of safety accidents are still in a high incidence stage. Based on the investigation and summary of safety risk events and their causes in urban rail transit engineering construction at home and abroad, this paper fully combines the current national security management policies, introduces the “dual control” concept of safety risk classification and hidden danger investigation, and develops the intelligent monitoring system platform for urban rail transit engineering construction based on advanced technologies such as intelligent Internet of Things, 3D visualization, and artificial intelligence. It realizes the intelligent collection and analysis of engineering field monitoring data, the dynamic early warning management of engineering risk sources, the process embedding “dual control” mechanism of safety risk and hidden danger investigation, the real-time supervision of large equipment operations such as shield and hoisting, and the real-time control of high-risk operation sections such as contact channels. At the same time, the traceability and assessment management of the safety supervision process are strengthened. The parties involved in the project can realize the synchronous sharing of information through the platform and improve the efficiency of on-site safety and quality control.