scholarly journals Effect of MATE 1, MATE 2 and OCT1 Single Nucleotide Polymorphisms on Metformin Action in Recently Diagnosed Egyptian Type-2 Diabetic Patients

2018 ◽  
Vol 11 (1) ◽  
pp. 149-157
Author(s):  
Gomaa Mostafa-Hedeab ◽  
Alaa Abdelhamed Mohamed ◽  
Gamal Thabet ◽  
Dina Sabry ◽  
Randa Fayez Salam ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Detection System ◽  
Diabetic Patients ◽  
Nucleotide Polymorphisms ◽  
Type 2 Diabetic Patients ◽  
Single Nucleotide ◽  
Sequence Detection ◽  
Factors Affecting ◽  
Type 2 Diabetic

Objective: to study the effect of MATE 1, MATE 2 and OCT1 genetic variants on metformin action in recently diagnosed Egyptian Type-2 diabetic patients. Patients & Methods: One hundred type-2 DM patients and forty healthy control were included in the study. All patients were recently diagnosed receiving no treatment before participation in the study. Three single nucleotide polymorphisms (SNPs) were Genotyped using real time PCR, Sequence Detection System: MATE1 (rs2252281), OCT1 coding variants (rs12208357) (SLC22A1) and MATE2 (rs12943590). Results: there is a significant differences between control and patients regarding MATE2 (p<0.05), OCT1 (P<0.005) distribution; in which GG (54%), CC (62%) is the most prevalent among studied patients respectively. MATE1 SNP; Patients with CC alleles and TT allele had better HBA1C (8.577±.2924), (8.7±.25) compared to CT allele patients (9.584±.3023) (P= .04) (P=.019) respectively. OCT1 SNP; CG allele patients showed better RBS (251±9.565) compared to CC allele (294.42±8.476) (p=0.004). Logistic regression test showed that RBS (p=.00001), ALT (p=.0001) and TLC (p=.025) are independent factors affecting blood glucose. Conclusion: MATE1 and OCT1 SNPs may have a potential role in metformin efficacy.

TCF7L2 rs7903146 C>T gene polymorphism is not associated with hypoglycemia in sulfonylurea-treated type 2 diabetic patients

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Georgia Ragia ◽  
Evgenia Katsika ◽  
Charalampia Ioannou ◽  
Vangelis G. Manolopoulos
Keyword(s):  
Common Adverse Effect ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Factors Affecting ◽  
Potential Association ◽  
Pcr Rflp ◽  
Polymerase Chain ◽  
Type 2 Diabetic ◽  
Tcf7l2 Rs7903146

Abstract Objectives Hypoglycemia is the most common adverse effect of sulfonylureas (SUs) and a major concern when using these drugs. Transcription factor 7-like 2 (TCF7L2) rs7903146 C>T polymorphism is an established and well characterized genetic marker of type 2 diabetes (T2DM) risk. The aim of the present study was to analyze the potential association of TCF7L2 rs7903146 C>T polymorphism with SU-induced hypoglycemia in a well characterized cohort of SU-treated patients previously genotyped for cytochrome P450 2C9 (CYP2C9) and P450 oxidoreductase (POR). Methods The study group consisted of 176 SU-treated T2DM patients of whom 92 had experienced at least one drug-associated hypoglycemic event. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for TCF7L2 rs7903146 genotyping. Results TCF7L2 rs7903146 C>T genotype and allele frequency did not differ between cases and controls (p=0.745 and 0.671, respectively). In logistic regression analysis adjusted for other factors affecting hypoglycemia, including CYP2C9 and POR genotypes, TCF7L2 rs7903146 C>T polymorphism did not increase the risk of hypoglycemia (OR=1.238, 95% C.I.=0.750–2.044, p=0.405). Conclusions TCF7L2 rs7903146 C>T polymorphism is not associated with SU-induced hypoglycemia. Identifying additional gene polymorphisms associated with SU-induced hypoglycemia is crucial for improving T2DM patient therapy with SUs.

Factors affecting hospitalization costs in Type 2 diabetic patients

2009 ◽  
Vol 23 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Eva Pagano ◽  
Simona Bo ◽  
Michele Petrinco ◽  
Rosalba Rosato ◽  
Franco Merletti ◽  
...  
Keyword(s):  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Factors Affecting ◽  
Hospitalization Costs ◽  
Type 2 Diabetic

scholarly journals Prevalence of Early B-Cell Factor 1 Gene rs4704963 Single Nucleotide Polymorphism (T>C) in a Population of Type 2 Diabetic Patients with Obesity

2018 ◽  
Vol 86 (5) ◽  
pp. 310-316
Author(s):  
Mario B. Principato ◽  
Rocío Castilla ◽  
Alejandra Duarte ◽  
Julio C. Bragagnolo ◽  
Graciela Ortensi ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
B Cell ◽  
Diabetic Patients ◽  
Nucleotide Polymorphism ◽  
Type 2 Diabetic Patients ◽  
Single Nucleotide ◽  
Early B Cell Factor ◽  
Type 2 Diabetic

scholarly journals Lack of Association betweenTLR4Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Danfeng Peng ◽  
Jie Wang ◽  
Jiemin Pan ◽  
Rong Zhang ◽  
Shanshan Tang ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Chinese Population ◽  
Diabetic Patients ◽  
Low Grade ◽  
Nucleotide Polymorphisms ◽  
Type 2 Diabetic Patients ◽  
Single Nucleotide ◽  
Patients With Diabetes ◽  
Low Grade Inflammation

Objective. Toll-like receptor 4 (TLR4) plays a central role in innate immunity. Activation of innate immune response and subsequent chronic low-grade inflammation are thought to be involved in the pathogenesis of diabetic nephropathy. In this study, we aimed to investigate whetherTLR4variants are associated with diabetic nephropathy in the Chinese population.Methods. Seven tagging single nucleotide polymorphisms (SNPs) ofTLR4based on HapMap Chinese data were genotyped in 1,455 Chinese type 2 diabetic patients. Of these patients, 622 were diagnosed with diabetic nephropathy and 833 were patients with diabetes for over 5 years but without diabetic nephropathy.Results. None of the SNPs and haplotypes showed significant association to diabetic nephropathy in our study. No association between the SNPs and quantitative traits was observed either.Conclusion. We concluded that common variants withinTLR4genes were not associated with diabetic nephropathy in the Chinese type 2 diabetes patients.

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