Incidence and prognosis of patients with spinal metastasis as the initial manifestation of malignancy

2019 ◽  
Vol 101-B (11) ◽  
pp. 1379-1384 ◽  
Author(s):  
Jin-Sung Park ◽  
Se-Jun Park ◽  
Chong-Suh Lee
Keyword(s):  
Surgical Treatment ◽  
Spinal Metastasis ◽  
Spinal Disease ◽  
Primary Malignancy ◽  
Initial Manifestation ◽  
Kaplan Meier ◽  
History Of ◽  
The Mean ◽  
The Difference

Aims This study aimed to evaluate the incidence and prognosis of patients with spinal metastasis as the initial manifestation of malignancy (SM-IMM). Patients and Methods We retrospectively reviewed the electronic medical records of 338 patients who underwent surgical treatment for metastatic spinal disease. The enrolled patients were divided into two groups. The SM-IMM group included patients with no history of malignancy whose site of primary malignancy was diagnosed after the identification of spinal metastasis. The other group included patients with a history of treatment for primary malignancy who then developed spinal metastasis (SM-DTM). The incidence of SM-IMM by site of primary malignancy was calculated. The difference between prognoses after surgical treatment for SM-IMM and SM-DTM was established. Results The median follow-up period was 11.5 months (interquartile range (IQR) 3.2 to 13.4) after surgical treatment. During the follow-up period, 264 patients died; 74 patients survived. The SM-IMM group consisted of 94 patients (27.8%). The site of primary malignancy in the SM-IMM group was lung in 35/103 patients (34.0%), liver in 8/45 patients (17.8%), kidney in 10/33 patients (30.3%), colorectum in 3/29 patients (10.3%), breast in 3/22 patients (13.6%), prostate in 3/10 patients (30%), thyroid in 4/8 patients (50%), and ‘other’ in 28/88 patients (31.8%). On Kaplan–Meier survival analysis, the SM-IMM group showed a significantly longer survival than the SM-DTM group (p = 0.013). The mean survival time was 23.0 months (95% confidence interval (CI) 15.5 to 30.5) in the SM-IMM group and 15.5 months (95% CI 11.8 to 19.2) in the SM-DTM group. Conclusion Of the 338 enrolled patients who underwent surgical treatment for spinal metastasis, 94 patients (27.8%) underwent surgical treatment for SM-IMM. The SM-IMM group had an acceptable prognosis with surgical treatment. Cite this article: Bone Joint J 2019;101-B:1379–1384.

The Carpal Boss

1995 ◽  
Vol 20 (3) ◽  
pp. 405-408 ◽  
Author(s):  
S. FUSI ◽  
H. K. WATSON ◽  
C. B. CUONO
Keyword(s):  
Surgical Treatment ◽  
Cancellous Bone ◽  
Symptomatic Relief ◽  
Surgical Patients ◽  
Male And Female ◽  
Articular Surfaces ◽  
History Of ◽  
The Mean ◽  
Bony Abnormality

Between 1969 and 1989,116 patients were evaluated and treated surgically for symptomatic carpal boss. Their mean age was 32 years and male and female patients were equally affected. 28 patients gave a history of previous injury. Surgical treatment consisted of excision of the localized bony abnormality and the associated degenerative arthritic process to the level of normal articular surfaces and normal adjacent cancellous bone. The mean follow-up period for the patients in this study was 42 months. Complete symptomatic relief was observed in 94% of the patients undergoing surgical treatment. Recurrence or persistence of symptoms developed in seven surgical patients. Six had a second operation with more extensive removal of sclerotic bone and degenerate cartilage, and all patients had relief of symptoms.

scholarly journals Experience of surgical treatment of infective endocarditis in children

2019 ◽  
pp. 67-83
Author(s):  
L. Prokopovуch ◽  
O. Golovenko ◽  
Y. Truba ◽  
M. Rudenko ◽  
O. Senyko ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Heart Defects ◽  
Subcutaneous Fat ◽  
Clinical Manifestations ◽  
Infectious Endocarditis ◽  
Average Weight ◽  
Kaplan Meier ◽  
The Mean

Surgical treatment of infectious endocarditis in children, single-center experience. The paper analyzes the experience of surgical treatment of infectious endocarditis (IE) in children. In the period from January 1999 to July 2019, 69 children with IE were operated at National Amosov Institute of Cardiovascular Surgery of NAMS of Ukraine, 44 of them (63.8%) developed the disease on the background of congenital heart defects (CHD). The mean age of the patients at the time of surgery was 9.1 ± 6.1 years. The average weight is 31.5 ± 21.7 (3.6 to 85 kg). The duration of the disease at the time of hospitalization was 5.3 ± 1.1 months. The average duration of the fever before hospitalization was 10.2 ± 8.5 weeks. Among the causes of IE, we observed three groups of inflammatory diseases: infections of the skin and subcutaneous fat in 15 (21.7%) cases, pathology of ENT – organs – 14 (20.2%) and broncho-pulmonary diseases – 9 (13.1%) cases. The risk factors were: presence of CHD – 44 (63.7%) and also nosocomial factors. The microbiological spectrum of pathogens included gram-positive microorganisms – 33 (71.7%), gram-negative microorganisms 4 (8.7%) and fungal microflora 9 (19.6%). The mean values of bypass circulation were 111.5 ± 62.4 minutes, and the time of aortic clamping was 71.4 ± 43.9 minutes, respectively. Hospital mortality in the general group of patients was 4 (5.8%) cases. In the follow-up period, 59 patients were examined, representing 90.7% of those discharged at the hospital stage. The observation period lasted from one month to 19.4 years (9.6 ± 5.7 years). According to the Kaplan-Meier analysis, the cumulative survival rate of patients in the CHD group at one year after surgery was 97.1%, at 10 years – 93.5%; after 15 years – 93.5%. Survival in the non-CHD group at 5, 10, and 15 years was 100%. In the long term, two patients died (3.4%). The recurrence rate of IE in the distant period was 2 (3.4%) cases. The incidence of long-term reoperation was 8 (13.6%) cases, three were recurrent IE and five were non-recurrent. According to Kaplan-Meier analysis, the proportion of patients without recurrent surgery in the long-term follow-up at 5 years was 87.9%, at 10 years – 84.1%, after 15 years – 77.1% in the CHD group. In the group without CHD 5 years – 95.2%, 10 years – 95.2%, 15 years – 81.6%. In the long term, as a result of performed surgical interventions, the regression of clinical manifestations of heart failure was noted in the majority of patients.

scholarly journals Relationship of femoral offset and clinical outcomes of femoral neck fracture patients following bipolar hip arthroplasty

2020 ◽  
Author(s):  
Sung Soo Kim ◽  
Hyeon Jun Kim ◽  
Seung Yup Lee
Keyword(s):  
Femoral Neck ◽  
Femoral Neck Fracture ◽  
Clinical Outcomes ◽  
Correlation Coefficient ◽  
Pearson Correlation ◽  
Neck Fracture ◽  
History Of ◽  
The Mean ◽  
The Difference

Abstract PurposeThis study aimed to investigate the relationship between femoral offset(FO) and clinical outcomes of patients with femoral neck fracture following bipolar hip arthroplasty(BHA). Materials and MethodsThis study recruited 520 patients who underwent BHA for femoral neck fracture from December 2003 to September 2018 with a minimum follow-up of one year. Excluding those with unclear medical records, a previous surgical history on the affected or contralateral hip, a congenital deformity and preoperative trauma history of the hip, high-energy multiple trauma, a history of neurodegenerative disease or cerebrovascular disease, a total of 77 patients were included in the analysis. The subjects were 54 females and 23 males. The mean age of patients was 74.6(65-95) years old and the mean follow-up period was 30.5 (12-136) months. For clinical assessment, postoperative pain visual analogue scale(VAS) and Harris hip score (HHS) were analyzed at each follow-up period. For radiological assessment, the difference in leg length discrepancy (LLD) and FO was measured. FO nearest to the real value was calculated using the values corrected for magnification and rotation errors on the anteroposterior view of plain radiographs taken at the first year of follow-up. In statistical analyses, the statistical significance between FO and clinical outcomes was analyzed using the Pearson correlation tests with SPSS v. 25.0. A value of p < 0.05 was considered statistically significant.ResultsThe difference in mean FO postoperatively was 6.7(±4.8) mm, and the difference in mean postoperative LLD was 4.9 (±3.4). The mean HHS was 77.1(±7.7), 82.3(±8.6), 83.4(±7.7), and 86.4(±6.7) at 1st , 3rd , 6th and 12th postoperative months, respectively. In the analysis using the Pearson correlation coefficient, the correlation coefficient between FO and HHS in 1-year follow-up was -0.38, and a significant outcome was found (p=0.001). Of HHS domain, the correlation coefficient for function in 1-year follow-up was -0.42, revealing a significant outcome (p=0.0001).ConclusionThere was a stastically significant correlation between clinical oucomes and FO difference at 1 year after BHA in patients with femoral neck fractures older than 65 years.

Longitudinal follow-up of vision in a neuromyelitis optica cohort

2013 ◽  
Vol 19 (10) ◽  
pp. 1320-1322 ◽  
Author(s):  
M Bouyon ◽  
N Collongues ◽  
H Zéphir ◽  
L Ballonzoli ◽  
L Jeanjean ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Past History ◽  
Optical Coherence ◽  
Individual Level ◽  
History Of ◽  
The Mean ◽  
The Difference

Background: Neuromyelitis optica (NMO) is an inflammatory disease associated with optic neuritis and myelitis. Recently, several studies showed that optical coherence tomography (OCT) could be an interesting method for the evaluation of disease severity; however, to date there are no studies with a longitudinal follow-up of visual function in NMO. The aim of this study was to assess the ability of OCT to evaluate the progression of visual dysfunction in NMO. Patients and methods: A group of 30 NMO patients (thus, 60 eyes), comprised of 20 women and 10 men with a mean age of 43.7 +/− 12.3 years, were prospectively evaluated clinically and by a whole neuro-ophthalmological work-up, including: visual acuity (VA), fundoscopy, visual evoked potential (VEP), visual field (VF) and optical coherence tomography (OCT). All patients were tested at baseline (after a mean disease duration of 6.1 years) and after a mean time of follow-up of 18 months (range: 12–36 months). Results: Mean VA was similar at the two evaluation times (0.77 +/− 0.36 versus 0.77 +/− 0.35). The mean VF defect decreased slightly, but the difference was not significant (−5.9 +/− 1.3 dB versus −5.3 +/− 1.3 dB). In contrast, the mean retinal thickness seen on OCT decreased from 87.4 +/− 23.3 µm to 79.7 +/- 22.4 µm ( p = 0.006). These modifications were only observed in eyes with a past or a recent history of optic neuritis (−15.1 µm; p < 0.001) and not in eyes without any history of optic neuritis (−2.4 µm; not significant). Also, they occurred independently of the occurrence of relapses ( n = 13) and especially optic neuritis episodes; however, the number of optic neuritis episodes was low ( n = 5). Conclusion: OCT seems to be a more sensitive test than VA or VF for monitoring ophthalmological function in NMO and it seems to be helpful for the detection of infra-clinical episodes in patients with a past history of optic neuritis. Our results suggest that this easily performed technique should be used in the follow-up of NMO, but complementary studies are warranted to confirm its interest at an individual level.

scholarly journals Tiempo de inicio de complicación obstétrica en embarazadas de alto riesgo de una comunidad Maya de Yucatán, México

2019 ◽  
pp. 1-5
Author(s):  
Elsa RODRÍGUEZ-ANGULO ◽  
Alejandro OSORIO-EUÁN ◽  
Ricardo OJEDA-RODRÍGUEZ ◽  
Jolly HOIL-SANTOS
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Onset Time ◽  
Timely Manner ◽  
Kaplan Meier ◽  
History Of ◽  
The Mean ◽  
Time Of Presentation ◽  
In Pregnancy

Objectives. To assess the onset time to present obstetric complications in high-risk pregnant women from the Mayan community of Mayapan, Yucatan, Mexico. Methodology. Longitudinal, retrospective, observational, descriptive, survival analysis type study. Follow-up was carried out for 46 weeks of 100 high-risk pregnant women. The event was the beginning time of presentation of the complication of the pregnant woman. Kaplan-Meier method was used for follow-up analysis. The mean follow-up time and overall survival at the end of pregnancy were calculated. Contribution. Provide the population with better prenatal control, refer in a timely manner to patients classified as high risk and have better control of records of pregnant women with a gyneco-obstetric history of risks, in order to reduce the incidence of complications in pregnancy and contribute to Maternal mortality reduction.

scholarly journals Relationship of Femoral Offset and Clinical Outcomes of Femoral Neck Fracture Patients Following Bipolar Hip Arthroplasty

2020 ◽  
Author(s):  
Sung Soo Kim ◽  
Hyeon Jun Kim ◽  
Seung Yup Lee
Keyword(s):  
Femoral Neck ◽  
Femoral Neck Fracture ◽  
Clinical Outcomes ◽  
Correlation Coefficient ◽  
Pearson Correlation ◽  
Neck Fracture ◽  
History Of ◽  
The Mean ◽  
The Difference

Abstract Background This study aimed to investigate the relationship between femoral offset(FO) and clinical outcomes of patients with femoral neck fracture following bipolar hip arthroplasty(BHA). Methods A hospital registry-based retrospective study, involving 520 patients who underwent BHA for femoral neck fracture and with a minimum follow-up of one year, Dong-A university hospital, from December 1, 2003, to September 31, 2018, was carried out. Excluding those with unclear medical records, a previous surgical history on the affected or contralateral hip, a congenital deformity and preoperative trauma history of the hip, high-energy multiple trauma, a history of neurodegenerative disease or cerebrovascular disease, a total of 77 patients were included in the analysis. The subjects were 54 females and 23 males. The mean age of patients was 74.6(65–95) years old and the mean follow-up period was 30.5 (12–136) months. For clinical assessment, postoperative pain visual analogue scale(VAS) and Harris hip score (HHS) were analyzed at each follow-up period. For radiological assessment, the difference in leg length discrepancy (LLD) and FO was measured. FO nearest to the real value was calculated using the values corrected for magnification and rotation errors on the anteroposterior view of plain radiographs taken at the first year of follow-up. In statistical analyses, the statistical significance between FO and clinical outcomes was analyzed using the Pearson correlation tests with SPSS v. 25.0. A value of p < 0.05 was considered statistically significant. Results The difference in mean FO postoperatively was 6.7(± 4.8) mm, and the difference in mean postoperative LLD was 4.9 (± 3.4). The mean HHS was 77.1(± 7.7), 82.3(± 8.6), 83.4(± 7.7), and 86.4(± 6.7) at 1st, 3rd, 6th and 12th postoperative months, respectively. In the analysis using the Pearson correlation coefficient, the correlation coefficient between FO and HHS in 1-year follow-up was − 0.38, and a significant outcome was found (p = 0.001). Of HHS domain, the correlation coefficient for function in 1-year follow-up was − 0.42, revealing a significant outcome (p = 0.0001). Conclusions There was a stastically significant correlation between clinical oucomes and FO difference at 1 year after BHA in patients with femoral neck fractures older than 65 years.

scholarly journals Acute bilateral foot drop with or without cauda equina syndrome—a case series

2021 ◽  
Vol 163 (4) ◽  
pp. 1191-1198
Author(s):  
Andreas K. Demetriades ◽  
Marco Mancuso-Marcello ◽  
Asfand Baig Mirza ◽  
Joseph Frantzias ◽  
David A. Bell ◽  
...  
Keyword(s):  
Cauda Equina Syndrome ◽  
Cauda Equina ◽  
Case Series ◽  
Foot Drop ◽  
Spinal Disease ◽  
Full Resolution ◽  
Degenerative Spinal Disease ◽  
The Mean ◽  
The One

Abstract Introduction Isolated acute bilateral foot drop due to degenerative spine disease is an extremely rare neurosurgical presentation, whilst the literature is rich with accounts of chronic bilateral foot drop occurring as a sequela of systemic illnesses. We present, to our knowledge, the largest case series of acute bilateral foot drop, with trauma and relevant systemic illness excluded. Methods Data from three different centres had been collected at the time of historic treatment, and records were subsequently reviewed retrospectively, documenting the clinical presentation, radiological level of compression, timing of surgery, and degree of neurological recovery. Results Seven patients are presented. The mean age at presentation was 52.1 years (range 41–66). All patients but one were male. All had a painful radiculopathic presentation. Relevant discopathy was observed from L2/3 to L5/S1, the commonest level being L3/4. Five were treated within 24 h of presentation, and two within 48 h. Three had concomitant cauda equina syndrome; of these, the first two made a full motor recovery, one by 6 weeks follow-up and the second on the same-day post-op evaluation. Overall, five out of seven cases had full resolution of their ankle dorsiflexion pareses. One patient with 1/5 power has not improved. Another with 1/5 weakness improved to normal on the one side and to 3/5 on the other. Conclusion When bilateral foot drop occurs acutely, we encourage the consideration of degenerative spinal disease. Relevant discopathy was observed from L2/3 to L5/S1; aberrant innervation may be at play. Cauda equina syndrome is not necessarily associated with acute bilateral foot drop. The prognosis seems to be pretty good with respect to recovery of the foot drop, especially if partial at presentation and if treated within 48 h.

scholarly journals Sialendoscopy With Intraductal Steroid Irrigation in Patients With Sialadenitis Without Sialoliths

2019 ◽  
Vol 98 (5) ◽  
pp. 291-294 ◽  
Author(s):  
Saudamini J. Lele ◽  
Mickie Hamiter ◽  
Torrey Louise Fourrier ◽  
Cherie-Ann Nathan
Keyword(s):  
Treatment Option ◽  
Case Series ◽  
Complete Response ◽  
Definitive Treatment ◽  
Invasive Technique ◽  
Effective Treatment Option ◽  
Patient Reported ◽  
History Of ◽  
The Mean

Sialendoscopy has emerged as a safe, effective and minimally invasive technique for management of obstructive and inflammatory salivary gland disease. The aim of our study was to analyze outcomes of sialendoscopy and steroid irrigation in patients with sialadenitis without sialoliths. We performed a retrospective analysis of patients who underwent interventional sialendoscopy with steroid irrigation from 2013 to 2016, for the treatment of sialadenitis without sialolithiasis. Twenty-two patients underwent interventional sialendoscopy with ductal dilation and steroid irrigation for the treatment of sialadenitis without any evidence of sialolithiasis. Conservative measures had failed in all. Eleven patients had symptoms arising from the parotid gland, 4 patients had symptoms arising from the submandibular gland, while 6 patients had symptoms in both parotid and submandibular glands. One patient complained of only xerostomia without glandular symptoms. The mean age of the study group which included 1 male and 21 females was 44.6 years (range: 3-86 years). Four patients had autoimmune disease, while 7 patients had a history of radioactive iodine therapy. No identifiable cause for sialadenitis was found in the remaining 11 patients. The mean follow-up period was 378.9 days (range: 16-1143 days). All patients underwent sialendoscopy with ductal dilation and steroid irrigation. Twelve patients showed a complete response and 9 patients had a partial response, while 1 patient reported no response. Only 3 patients required repeat sialendoscopy. The combination of sialendoscopy with ductal dilation and steroid irrigation is a safe and effective treatment option for patients with sialadenitis without sialoliths refractory to conservative measures. Prospective studies with a larger case series are needed to establish its role as a definitive treatment option.

scholarly journals Utilization of laser interstitial thermotherapy guided by real-time thermal MRI as an alternative to separation surgery in the management of spinal metastasis

2015 ◽  
Vol 23 (4) ◽  
pp. 400-411 ◽  
Author(s):  
Claudio E. Tatsui ◽  
R. Jason Stafford ◽  
Jing Li ◽  
Jonathan N. Sellin ◽  
Behrang Amini ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Spinal Cord ◽  
Real Time ◽  
Spinal Cord Compression ◽  
Spinal Metastasis ◽  
Cord Compression ◽  
The Mean ◽  
Interstitial Thermotherapy

OBJECT High-grade malignant spinal cord compression is commonly managed with a combination of surgery aimed at removing the epidural tumor, followed by spinal stereotactic radiosurgery (SSRS) aimed at local tumor control. The authors here introduce the use of spinal laser interstitial thermotherapy (SLITT) as an alternative to surgery prior to SSRS. METHODS Patients with a high degree of epidural malignant compression due to radioresistant tumors were selected for study. Visual analog scale (VAS) scores for pain and quality of life were obtained before and within 30 and 60 days after treatment. A laser probe was percutaneously placed in the epidural space. Real-time thermal MRI was used to monitor tissue damage in the region of interest. All patients received postoperative SSRS. The maximum thickness of the epidural tumor was measured, and the degree of epidural spinal cord compression (ESCC) was scored in pre- and postprocedure MRI. RESULTS In the 11 patients eligible for study, the mean VAS score for pain decreased from 6.18 in the preoperative period to 4.27 within 30 days and 2.8 within 60 days after the procedure. A similar VAS interrogating the percentage of quality of life demonstrated improvement from 60% preoperatively to 70% within both 30 and 60 days after treatment. Imaging follow-up 2 months after the procedure demonstrated a significant reduction in the mean thickness of the epidural tumor from 8.82 mm (95% CI 7.38–10.25) before treatment to 6.36 mm (95% CI 4.65–8.07) after SLITT and SSRS (p = 0.0001). The median preoperative ESCC Grade 2 was scored as 4, which was significantly higher than the score of 2 for Grade 1b (p = 0.04) on imaging follow-up 2 months after the procedure. CONCLUTIONS The authors present the first report on an innovative minimally invasive alternative to surgery in the management of spinal metastasis. In their early experience, SLITT has provided local control with low morbidity and improvement in both pain and the quality of life of patients.

Frequency, Predictors, and Outcome of Seizures in Patients With Myelomeningocele: Single-Center Retrospective Cohort Study

2021 ◽  
pp. 088307382110531
Author(s):  
Cemal Karakas ◽  
Emin Fidan ◽  
Kapil Arya ◽  
Troy Webber ◽  
Joan B. Cracco
Keyword(s):  
Good Prognosis ◽  
Cortical Atrophy ◽  
Seizure Freedom ◽  
Single Center ◽  
Seizure Onset ◽  
Shunt Procedure ◽  
History Of ◽  
The Mean

To determine the frequency, predictors, and outcomes of seizures in patients with myelomeningocele, we retrospectively analyzed the data from patients with myelomeningocele followed longitudinally at a single center from 1975 to 2013. We identified a total of 122 patients (61% female). The mean follow-up duration was 11.1 years (minimum-maximum = 0-34.5 years, SD = 8.8, median = 9.1 years). A total of 108 (88.5%) patients had hydrocephalus, and 98 (90.7%) of those patients required a ventriculoperitoneal shunt procedure. Twenty-four (19.7%) patients manifested with seizures, 23 of whom had hydrocephalus. The average age of seizure onset was 4.8 years (median 2 years of age). Falx dysgenesis ( P = .004), lumbar myelomeningocele ( P = .007), and cortical atrophy ( P = .028) were significantly associated with epileptic seizure development. The average seizure-free period at the last follow-up in patients with a history of myelomeningocele and seizures was 8.1 years. We conclude that myelomeningocele patients with seizures have an overall good prognosis with considerable long-term seizure freedom.

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