scholarly journals Association between periodontal disease, number of remaining teeth and high-sensitivity C-reactive protein in Korean adults aged 40 and older: Based on data from 2015 Korea National Health and Nutrition Examination Survey

2020 ◽  
Vol 20 (3) ◽  
2003 ◽  
Vol 49 (8) ◽  
pp. 1353-1357 ◽  
Author(s):  
Earl S Ford ◽  
Wayne H Giles ◽  
Gary L Myers ◽  
Nader Rifai ◽  
Paul M Ridker ◽  
...  

Abstract Background: The distribution of C-reactive protein (CRP) concentrations among children and young adults in the US is not known at present. Methods: We used data from 3348 US children and young adults 3–19 years of age who participated in the National Health and Nutrition Examination Survey, 1999–2000, to describe the distribution of CRP concentrations, based on results obtained with a high-sensitivity latex-enhanced turbidimetric assay. Results: The range of CRP concentrations was 0.1–90.8 mg/L (mean, 1.6 mg/L; geometric mean, 0.5 mg/L; median, 0.4 mg/L). CRP concentrations increased with age. Females 16–19 years of age had higher concentrations than males in this age range (P = 0.003). Mexican Americans had the highest CRP concentrations among the three major race or ethnic groups (P <0.001). Conclusions: For the first time, these data describe the CRP concentration distribution among US children and young adults, based on results obtained with a high-sensitivity assay.


2020 ◽  
Author(s):  
Se-Won Park ◽  
Seong-Sik Park ◽  
Eun-Jung Kim ◽  
Won-Suk Sung ◽  
In-Hyuk Ha ◽  
...  

Abstract Background No studies have investigated the association between self-rated health (SRH) and high-sensitivity C-reactive protein (hs-CRP) in South Koreans. This study explored the association and analyzed any sex differences.Method Using data from the 2015-2017 Korea National Health and Nutrition Examination Survey, we analyzed the association between SRH and high group (>1.0 mg/L) in 14,544 Koreans aged ≥19 years who responded to the SRH survey and who had hs-CRP test results. Results The percentage of having a very poor to poor SRH was higher in the high hs-CRP level group (22.4%) than in the low level group (17.66%). Among males, the risk of a high hs-CRP level increased with worse SRH (adjusted for confounders; P for trend <0.001). After adjusting for all confounders, including chronic diseases, males with a very poor SRH showed higher odds ratio (OR) for high group than those with a very good SRH (fully adjusted OR, 1.74; 95% confidence interval, 1.04-2.90). Significant correlations were absent among females. Conclusions A poor SRH was correlated with low-grade inflammation (high hs-CRP level) among male Korean adults. The findings could be useful for developing health improvement programs and in goal setting at a national scale.


2021 ◽  
Vol 9 ◽  
Author(s):  
Cristin D. W. Kaspar ◽  
Juan Lu

Importance: High uric acid (UA) is hypothesized to worsen kidney and cardiovascular disease morbidity via activation of systemic inflammation. Clinical trials of UA modification report reduction of the inflammatory marker high sensitivity C-reactive protein (hs-CRP) as an outcome measure, but studies have not demonstrated that hyperuricemia independently increases hs-CRP when adjusted for important confounders such as body mass index (BMI), sex, and age.Objective: To identify clinical risk factors for elevated hs-CRP, including but not limited to hyperuricemia, through a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) 2015–2018.Results: In the final multivariate logistic regression model, the exposure with the strongest effect on the odds of elevated hs-CRP was BMI in the fourth quartile, OR = 13.1 (95% CI 6.25–27.42), followed by female sex (OR = 4.9, 95% CI 2.92–8.34), hyperuricemia (OR = 2.2, 95% CI 1.36–3.45), urine albumin creatinine ratio (ACR; OR = 1.5, 95% CI 1.09–2.18), poor overall health (OR = 1.4, 95% CI 1.18–1.58), and interactions between hyperuricemia and sex (OR = 1.4, 95% CI 1.05–1.83), and between BMI and sex (OR = 1.2, 95% CI 1.03–1.47). Notably, chronic kidney disease (CKD) and CKD surrogates were not associated with hs-CRP despite urine ACR maintaining a significant independent effect.Conclusions: In this national population-based study, we demonstrated that hyperuricemia significantly increases the odds of elevated hs-CRP, independent from BMI, female sex, urine ACR, and overall health status. Further study is recommended to better understand the sex difference in this association and the role of albuminuria, but not CKD, in systemic inflammation.


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