Another Fatal Case of Hyperphosphatemia Associated with a Phosphosoda Bowel Preparation; Intravenous Immune Globulin Causes Myocardial Infarction; Hepatotoxicity Due to Acarbose Therapy; Mitochondrial Toxicity with Linezolid; Venlafaxine and the Rapid Development of Anasarca; Neuropathy Exacerbated by Rituximab Therapy; Drug-Related Emergency Department Visits in an Elderly Population; House Staff Report on Adverse Events and Their Causes

2006 ◽  
Vol 41 (3) ◽  
pp. 225-304
Author(s):  
Joel Shuster
2021 ◽  
Vol 3 (1) ◽  
pp. 1-155
Author(s):  
Malaysian Society of Neurosciences

The 1st Clinical Practice Guideline (CPG) on the management of ischaemic stroke was published in 2006 and the second edition was published in 2012. Since then, there was a rapid development in the management of acute stroke, mainly with the improvement and advancement of reperfusion therapy, encompassing both medical thrombolysis and mechanical thrombectomy. Furthermore, the importance of timely intervention, especially in the emergency department, had significantly improved the outcome in stroke patients. Therefore, this current CPG emphasizes the hyperacute management and has introduced new chapters, for example, emergency medical services. With the growing numbers of elderly population in Malaysia, we have also included a new chapter on stroke in the older person. This 3rd edition was developed to provide a clear and concise approach based on current evidence with the focus being on the efforts to reduce time and improve pre-hospital care. We have summarised and adapted relevant clinical trials data and published literatures to our local practice.


2011 ◽  
Vol 126 (3) ◽  
pp. 312-317 ◽  
Author(s):  
Maribeth C. Lovegrove ◽  
Nadine Shehab ◽  
Craig M. Hales ◽  
Kathy Poneleit ◽  
Elizabeth Crane ◽  
...  

2015 ◽  
Vol 115 (2) ◽  
pp. 167-170 ◽  
Author(s):  
Michael J. Ward ◽  
Sunil Kripalani ◽  
Yuwei Zhu ◽  
Alan B. Storrow ◽  
Robert S. Dittus ◽  
...  

2010 ◽  
Vol 27 (Suppl 1) ◽  
pp. A6.2-A6
Author(s):  
Richard Body

BackgroundIn recent years there has been growing interest in the identification of novel biomarkers that may enable early exclusion of acute coronary syndromes (ACS) in the Emergency Department (ED). Soluble CD40 ligand (sCD40L) has been identified as a potential marker of coronary plaque destabilisation and platelet activation. We aimed to investigate the value of sCD40L measured at the time of ED presentation for enabling early diagnosis and exclusion of ACS.MethodsWe recruited patients presenting to the ED with suspected cardiac chest pain within the previous 24 h. We measured sCD40L in plasma samples taken at the point of ED presentation. All patients had troponin T measured at least 12 h after symptom onset and were followed up for 6 months for adverse events (death, acute myocardial infarction (AMI) or the need for urgent revascularisation).Results706 patients were recruited to the study. sCD40L levels were significantly lower in smokers, in patients with hyperlipidaemia or prior coronary revascularisation and in patients taking statins, r angiotensin-converting enzyme or calcium blockers. There was no significant difference in sCD40L levels between patients with (median 33.8ng/ml, IQR 18.0–80.5) and without (36.3 ng/ml, IQR 14.2–94.3) AMI (p=0.92) or between patients who did (34.0 ng/ml, 14.2–94.3) and who did not (34.9, 18.2–80.4) develop adverse events (p=0.82). The area under the Receiver Operating Characteristic curve was 0.50 (95% CI 0.45 to 0.56) for AMI and 0.49 (0.44–0.55) for adverse events. There was no trend towards increasing incidence of either outcome with ascending quintiles of sCD40L.ConclusionssCD40L is unhelpful in the ED diagnosis of ACS. Future work in this area should focus on other biomarkers.


2018 ◽  
Vol 33 (7) ◽  
pp. 1060-1068 ◽  
Author(s):  
Andrew I. Geller ◽  
Maribeth C. Lovegrove ◽  
Nadine Shehab ◽  
Lauri A. Hicks ◽  
Mathew R. P. Sapiano ◽  
...  

PEDIATRICS ◽  
2010 ◽  
Vol 126 (2) ◽  
pp. 247-259 ◽  
Author(s):  
C. Wang ◽  
B. Hefflin ◽  
J. U. Cope ◽  
T. P. Gross ◽  
M. B. Ritchie ◽  
...  

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