Recurrent urethral pain syndrome in a pregnant patient: A case for low dose broad spectrum oral antibiotics

The aim: demonstration of our experience of surgical treatment of patients with migrated intrauterine device (IUD) into the abdominal cavity. The results of surgical treatment of migrated IUDs in the pelvic cavity are summarized in 17 women. The average age of the patients was 33,23,4 years. The timing of implantation of the IUDs varied from 10 days to 24 months. In all cases, the intra operational finding was T-shaped a copper device. The reason behind the women's consultation was an increase in pain syndrome in the lesser pelvis (n=15), dysuric phenomenon (n=1) and the onset of pregnancy (n=1). Perforation of the uterus and migration of the spiral occurred from 10 days to 2 years after its implantation. All patients were operated laparoscopicaly. The average duration of operations was 45,510,5 minutes. In the postoperative period there were no complications from the pelvic organs and postoperative wounds. The period of hospitalization of patients was 3,50,7 days. In all cases there was a regression of clinical signs and recovery. In one pregnant patient (gestation period 5-6 weeks) the pregnancy proceeded without particular pathological abnormalities and resulted in the birth of a full-term child. Laparoscopic removal of the IUD migrating from the uterine cavity to the abdominal cavity is the method of choice in the treatment of this group of patients, avoiding development of intra- and postoperative complications and a shorter length of stay in the hospital. The effectiveness of the procedure reaches 100%. The most common cause of complication of the IUD is the perforation of the uterus during its implantation.

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PD62-01 DAILY LOW DOSE TADALAFIL IN TREATMENT OF CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROME: RANDOMIZED CONTROLLED STUDY OF EFFICACY AND SAFETY

The Journal of Urology ◽

10.1016/j.juro.2018.02.2837 ◽

2018 ◽

Vol 199 (4S) ◽

Author(s):

Alaa Abdalla El Sayed ◽

hamdy dosyky ◽

aref marouf ◽

mohamrd nady ◽

gamal ragab ◽

...

Keyword(s):

Pelvic Pain ◽

Chronic Prostatitis ◽

Chronic Pelvic Pain ◽

Low Dose ◽

Chronic Pelvic Pain Syndrome ◽

Pain Syndrome ◽

Controlled Study ◽

Pelvic Pain Syndrome ◽

Efficacy And Safety ◽

Randomized Controlled

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The effect of intravesical cocktail therapy combined with low-dose amitriptyline on primary bladder pain syndrome

International Urogynecology Journal ◽

10.1007/s00192-021-05043-y ◽

2022 ◽

Author(s):

Deniz Abat ◽

Adem Altunkol ◽

Fatih Gökalp

Keyword(s):

Low Dose ◽

Pain Syndrome ◽

Bladder Pain Syndrome ◽

Bladder Pain ◽

Primary Bladder

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The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice

Signal Transduction and Targeted Therapy ◽

10.1038/s41392-021-00750-w ◽

2021 ◽

Vol 6 (1) ◽

Author(s):

Wenqiang Sun ◽

Lihong He ◽

He Zhang ◽

Xiaodong Tian ◽

Zhihua Bai ◽

...

Keyword(s):

Receptor Binding ◽

Humoral Immunity ◽

Broad Spectrum ◽

Neutralizing Antibodies ◽

Protective Immunity ◽

Cellular Response ◽

Low Dose ◽

The Self ◽

Receptor Binding Domain ◽

Self Assembled

AbstractAs COVID-19 continues to spread rapidly worldwide and variants continue to emerge, the development and deployment of safe and effective vaccines are urgently needed. Here, we developed an mRNA vaccine based on the trimeric receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein fused to ferritin-formed nanoparticles (TF-RBD). Compared to the trimeric form of the RBD mRNA vaccine (T-RBD), TF-RBD delivered intramuscularly elicited robust and durable humoral immunity as well as a Th1-biased cellular response. After further challenge with live SARS-CoV-2, immunization with a two-shot low-dose regimen of TF-RBD provided adequate protection in hACE2-transduced mice. In addition, the mRNA template of TF-RBD was easily and quickly engineered into a variant vaccine to address SARS-CoV-2 mutations. The TF-RBD multivalent vaccine produced broad-spectrum neutralizing antibodies against Alpha (B.1.1.7) and Beta (B.1.351) variants. This mRNA vaccine based on the encoded self-assembled nanoparticle-based trimer RBD provides a reference for the design of mRNA vaccines targeting SARS-CoV-2.

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Effects of Cranberry Juice on Pharmacokinetics of β-Lactam Antibiotics following Oral Administration

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00774-08 ◽

2009 ◽

Vol 53 (7) ◽

pp. 2725-2732 ◽

Cited By ~ 12

Author(s):

Meng Li ◽

Marilee A. Andrew ◽

Joanne Wang ◽

David H. Salinger ◽

Paolo Vicini ◽

...

Keyword(s):

Low Dose ◽

Recurrent Urinary Tract Infection ◽

Oral Absorption ◽

Test Dose ◽

Membrane Transporters ◽

Oral Antibiotics ◽

Cranberry Juice ◽

Oral Test ◽

Concurrent Use ◽

Dose Oral

ABSTRACT Cranberry juice consumption is often recommended along with low-dose oral antibiotics for prophylaxis for recurrent urinary tract infection (UTI). Because multiple membrane transporters are involved in the intestinal absorption and renal excretion of β-lactam antibiotics, we evaluated the potential risk of pharmacokinetic interactions between cranberry juice and the β-lactams amoxicillin (amoxicilline) and cefaclor. The amoxicillin-cranberry juice interaction was investigated in 18 healthy women who received on four separate occasions a single oral test dose of amoxicillin at 500 mg and 2 g with or without cranberry juice cocktail (8 oz) according to a crossover design. A parallel cefaclor-cranberry juice interaction study was also conducted in which 500 mg cefaclor was administered with or without cranberry juice cocktail (12 oz). Data were analyzed by noncompartmental methods and nonlinear mixed-effects compartmental modeling. We conclude that the concurrent use of cranberry juice has no significant effect on the extent of oral absorption or the renal clearance of amoxicillin and cefaclor. However, delays in the absorption of amoxicillin and cefaclor were observed. These results suggest that the use of cranberry juice at usual quantities as prophylaxis for UTI is not likely to alter the pharmacokinetics of these two oral antibiotics.

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