Potential for the Use of Adamantanes for the Prevention and Treatment of the Neurological Complications of COVID-19

154 Background: Neurological complications such as chemotherapy-induced peripheral neuropathy (CIPN) and neuropathic pain are frequent side-effects of neurotoxic chemotherapy agents. An increasing survival rate and frequent administration of adjuvant chemotherapy treatments involving neurotoxic agents makes it imperative that accurate diagnosis, prevention and treatment of these neurological complications be implemented to minimize the burden experienced by patients undergoing these treatments. Methods: To determine the potential use of pharmaceuticals, nutraceuticals and herbal medicines as adjuvants in cancer treatments a critical literature review was conducted by electronic and manual search on nine databases. These include PubMed, the Cochrane Library, Science Direct, Scopus, EMBASE, MEDLINE, Google Scholar and two Chinese databases CNKI and CINAHL. Thirty studies were selected for pharmaceutical agents, twenty-four studies for nutraceuticals and thirty-four studies for herbal medical trials. Seven acupuncture trials were also identified in relation to CIPN management. Data was collated and organised into chemotherapy drugs, agent’s trialled, number of participants, results and recommendations. Results: For pharmaceutical agents, amifostine has possible ototoxicity protection for children in cisplatin and duloxetine as a treatment option for pain. For nutraceuticals, vitamin E was found to have protective abilities for cisplatin ototoxicity, omega 3 fatty acids for taxane administration and vitamin B6 and lipoic acid for oxaliplatin CIPN. In herbal medicine, Goshajinkigan showed great promise for oxaliplatin-IPN protection. Vitamin B12 deficiencies have also been found to increase the onset and severity of CIPN. Conclusions: Currently, no pharmaceutical, nutraceutical or complementary agent has been found to be completely beneficial in preventing or treating CIPN. It is suggested clinicians identify the best option from the research to assist patients in both possible prevention and treatment of CIPN. In addition, research has found that a vitamin B12 deficiency may potentiate moderate to severe CIPN presentation and testing of this vitamin is suggested.

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Neurological disorders associated with Covid-19 (literature review)

Medical Science And Education Of Ural ◽

10.36361/1814-8999-2020-21-4-140-144 ◽

2020 ◽

Vol 21 (4) ◽

pp. 140-144

Author(s):

M. A. Ahmet’yanov ◽

◽

O. A. Kicherova ◽

L. I. Reikhert ◽

M. V. Deeva ◽

...

Keyword(s):

Nervous System ◽

Literature Review ◽

Healthcare System ◽

Neurological Disorders ◽

Neurological Complications ◽

Pathological Conditions ◽

Prevention And Treatment ◽

Coronavirus Infection ◽

Human Nervous System

The pandemic of the new SARS-CoV2, that started at the beginning of 2020, caused a catastrophic increase in morbidity and mortality in early 2020 and posed a number of challenges for healthcare system. Primarily, this concerns the study of the effect on different organs and systems, that new virus can exhibit. This knowledge further can serve as a key to the development of effective methods for the prevention and treatment of COVID-19 associated pathological conditions. The objectives of this review include the analysis of neurological complications caused by the new coronavirus infection and the determination of the possible mechanisms of the virus’s effect on the human nervous system.

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Current and Future Treatment Considerations in the Management of Aneurysmal Subarachnoid Hemorrhage

Journal of Pharmacy Practice ◽

10.1177/0897190010372334 ◽

2010 ◽

Vol 23 (5) ◽

pp. 408-424 ◽

Cited By ~ 4

Author(s):

Denise H. Rhoney ◽

Karen McAllen ◽

Xi Liu-DeRyke

Keyword(s):

Subarachnoid Hemorrhage ◽

Aneurysmal Subarachnoid Hemorrhage ◽

Supportive Therapy ◽

Neurological Complications ◽

Stunned Myocardium ◽

Medical Complications ◽

Pharmacological Management ◽

Quality Literature ◽

Prevention And Treatment ◽

Treatment Considerations

Aneurysmal subarachnoid hemorrhage (aSAH) is a type of hemorrhagic stroke that can cause significant morbidity and mortality. Although guidelines have been published to help direct the care of these patients, there is insufficient quality literature regarding the medical and pharmacological management of patients with aSAH. Treatment is divided into 3 categories: supportive therapy, prevention of complications, and treatment of complications. There are numerous pharmacological therapies that are targeted at prevention and treatment of the neurological and medical complications that may arise. Rebleeding, hydrocephalus, cerebral vasospasm, and seizures are the most common neurological complications while the most common medical complications include hyponatremia, pulmonary edema, cardiac arrhythmias, neurogenic stunned myocardium, fever, anemia, infection, hyperglycemia, and venous thromboembolism. Risk factors, clinical presentation, diagnosis, pathophysiology, as well as initial management, prevention, and treatment of complications will be the focus of this discussion.

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Patient management with diabetes mellitus in outpatient practice: prevention and treatment of vascular and neurological complications

Consilium Medicum ◽

10.26442/20751753.2019.4.190325 ◽

2019 ◽

Vol 21 (4) ◽

pp. 45-49

Author(s):

Tatiana E. Morozova ◽

◽

Natalia A. Konyshko ◽

Keyword(s):

Diabetes Mellitus ◽

Patient Management ◽

Neurological Complications ◽

Prevention And Treatment ◽

Outpatient Practice

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