Neurological disorders associated with Covid-19 (literature review)

2020 ◽  
Vol 21 (4) ◽  
pp. 140-144
Author(s):  
M. A. Ahmet’yanov ◽  
◽  
O. A. Kicherova ◽  
L. I. Reikhert ◽  
M. V. Deeva ◽  
...  
Keyword(s):  
Nervous System ◽  
Literature Review ◽  
Healthcare System ◽  
Neurological Disorders ◽  
Neurological Complications ◽  
Pathological Conditions ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Human Nervous System

The pandemic of the new SARS-CoV2, that started at the beginning of 2020, caused a catastrophic increase in morbidity and mortality in early 2020 and posed a number of challenges for healthcare system. Primarily, this concerns the study of the effect on different organs and systems, that new virus can exhibit. This knowledge further can serve as a key to the development of effective methods for the prevention and treatment of COVID-19 associated pathological conditions. The objectives of this review include the analysis of neurological complications caused by the new coronavirus infection and the determination of the possible mechanisms of the virus’s effect on the human nervous system.

scholarly journals Neurological and mental disorders associated with COVID-19

2020 ◽  
Vol 26 (3) ◽  
pp. 317-326
Author(s):  
L. B. Novikova ◽  
A. P. Akopian ◽  
K. M. Sharapova ◽  
R. F. Latypova
Keyword(s):  
Nervous System ◽  
Mental Disorders ◽  
Emotional Disorders ◽  
Neurological Disorders ◽  
Neurological Complications ◽  
Toxic Encephalopathy ◽  
Clinical Observations ◽  
Demyelinating Lesions ◽  
Coronavirus Infection ◽  
Neurological Pathology

The article presents a narrative review, clinical observations. Special attention is given to the pathogenesis, features of neurological manifestations and mental disorders, neurological complications in coronavirus infection, illustrated by clinical cases. Neurological disorders occur in approximately 36,4 % patients with COVID-19. Currently, severe viral hemorrhagic encephalitis, toxic encephalopathy, acute demyelinating lesions of the peripheral nervous system, stroke, behavioral and emotional disorders have been described. Despite numerous publications on the neurological pathology in COVID-19, pathogenesis, risk factors, and relation between neurological disorders and coronavirus infection remain unclear. There is a need for systematization of the accumulated data on the damage to the nervous system during the COVID-19 epidemic for clinical routine use, further development of the optimal treatment strategy and implementation of effective preventive measures.

scholarly journals Analytical Methods for the Determination of Neuroactive Steroids

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 553
Author(s):  
Michal Kaleta ◽  
Jana Oklestkova ◽  
Ondřej Novák ◽  
Miroslav Strnad
Keyword(s):  
Nervous System ◽  
Steroid Hormone ◽  
Neuroactive Steroids ◽  
Physiological Changes ◽  
Biological Matrices ◽  
Pathological Conditions ◽  
Reliable Monitoring ◽  
Hormonal Steroids ◽  
Endocrine Tissues

Neuroactive steroids are a family of all steroid-based compounds, of both natural and synthetic origin, which can affect the nervous system functions. Their biosynthesis occurs directly in the nervous system (so-called neurosteroids) or in peripheral endocrine tissues (hormonal steroids). Steroid hormone levels may fluctuate due to physiological changes during life and various pathological conditions affecting individuals. A deeper understanding of neuroactive steroids’ production, in addition to reliable monitoring of their levels in various biological matrices, may be useful in the prevention, diagnosis, monitoring, and treatment of some neurodegenerative and psychiatric diseases. The aim of this review is to highlight the most relevant methods currently available for analysis of neuroactive steroids, with an emphasis on immunoanalytical methods and gas, or liquid chromatography combined with mass spectrometry.

scholarly journals Multimodality MRI Findings in Patients with End-Stage Renal Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Hui Juan Chen ◽  
Long Jiang Zhang ◽  
Guang Ming Lu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Neurological Disorders ◽  
Neurological Complications ◽  
Mri Findings ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Patients with end-stage renal disease (ESRD) suffer from a number of complex neurological complications including vascular damage and cognitive dysfunction. It is of great significance to detect the neurological complications and improve the prognosis of ESRD patients. Many new noninvasive MRI techniques have been steadily used for the diagnosis of occult central nervous system complications in ESRD patients. This gives an opportunity to understand the pathophysiological mechanisms of these neurological disorders. This paper is a review that presents the MRI findings of occult brain damage in ESRD patients, outlines the applications of advanced MRI techniques, and introduces a brief perspective in this study field.

scholarly journals Neurological disorders in autism: A systematic review and meta-analysis

Autism ◽  
2020 ◽  
pp. 136236132095137 ◽  
Author(s):  
Pei-Yin Pan ◽  
Sven Bölte ◽  
Preet Kaur ◽  
Sadia Jamil ◽  
Ulf Jonsson
Keyword(s):  
Systematic Review ◽  
Health Care ◽  
Nervous System ◽  
Cerebral Palsy ◽  
General Population ◽  
Neurological Disorders ◽  
Migraine Headache ◽  
Meta Analysis ◽  
Full Range ◽  
Neurological Complications

The etiological significance of neurological disorders in autism is debated, but it is clear that they complicate support provision and clinical management, and can have negative impact on outcomes. This systematic review and meta-analysis explored the full range of co-occurring neurological disorders in autism. We estimated the odds of having neurological complications compared to the general population and other neurodevelopmental conditions, as well as the overall prevalence of different neurological disorders. Seventy-nine articles were eligible for the systematic review, including 28 case-control studies, 43 prevalence studies, and 8 cohort studies. Findings were heterogeneous across studies. Overall, autistic individuals were significantly more likely than the general population to exhibit epilepsy, macrocephaly, hydrocephalus, cerebral palsy, migraine/headache, and congenital abnormalities of the nervous system, with prevalence estimates ranging from 1.1% (0%–3.3%; hydrocephalus) to 14.2% (11.3%–17.2%; epilepsy). Epilepsy was also more common in autism than in attention-deficit/hyperactivity disorder (odds ratio [95% confidence interval] = 4.06 [2.81–5.88]). Findings indicate that awareness of neurological disorders and neurological check-ups are indicated in autism to ensure adequate physical health care and support. Prospective studies of neurological disorders in children diagnosed with or at risk of autism might further enhance our understanding of causal pathways. Lay abstract Neurological disorders, such as epilepsy and cerebral palsy, have been reported to occur among individuals with autism beyond chance and may have an impact on daily living across the lifespan. Although there has been research investigating neurological disorders in autism, the findings are not always conclusive. Previous summaries of existing studies have not evaluated the full range of neurological disorders. This study aimed to comprehensively explore the neurological problems appearing in autism to provide updated information that is needed for better healthcare and support in this population. We looked at already published studies focusing on risk or frequency of neurological disorders in autism. Our results suggest that individuals with autism are more likely than the general population to have a range of neurological disorders, including epilepsy, macrocephaly, hydrocephalus, cerebral palsy, migraine/headache, and inborn abnormalities of the nervous system. In order to provide individualized healthcare and support of high quality to individuals diagnosed with autism, health care professionals and other support providers need to be attentive to neurological complications. To further improve our understanding about the link between autism and neurological disorders, future research should follow the neurological health of children who are diagnosed with or are at increased likelihood of autism.

scholarly journals Neurology of COVID-19

2021 ◽  
Keyword(s):  
Nervous System ◽  
Neurological Disorders ◽  
Neurological Complications ◽  
Reference Book ◽  
Direct Response ◽  
New Developments ◽  
Specific Subject ◽  
International Experts ◽  
The Impact ◽  
Extensive Clinical Experience

The authors will present a comprehensive account of the neurological aspects of SARS-CoV-2 infection. The aim is to provide a practical clinical book which will serve as a guide for clinicians from all specialties involved in the management of COVID-19 patients. The authors share the extensive clinical experience gained in major hospitals in Lombardy, the first European region to face the COVID-19 emergency in 2020. All are recognized international experts in their respective fields and have been involved in the management of COVID-19 cases from the very beginning of the Italian SARS-CoV-2 outbreak. The text begins with a description of pathobiological and pathophysiological aspects related to the involvement of the nervous system, moving on to the discussion of the neurological complications observed in COVID-19 patients; these range from central to peripheral symptoms, and can occur in the acute or post-acute phases of the disease. Further topics are: neuropathology, seizures and EEG, neuroimaging, delirium, encephalomyelitis, stroke, psychopathology and psychiatry, neuropsychology and cognitive impairment, neuromuscu-lar disorders, and the impact of COVID-19 on other pre-existing neurological disorders. In addi-tion, the book will discuss the new developments in teleneurology approaches, which have been a direct response to the ongoing pandemic. Finally, the possible neurological complications of the COVID-19 vaccines and the neurological complications in children will be considered.Each chapter will present a critical review of the existing literature concerning the specific subject matter, followed by practical clinical recommendations, as well as personal considerations based on the experience gained by each author during the course of the COVID-19 pandemic. Neurology of COVID-19 will be an original and innovative reference book for clinicians of all the specialties involved in the management of patients with SARS-CoV-2 infection

scholarly journals Pharmacoresistance in epilepsy and ways for overcoming it (literature review)

2020 ◽  
Vol 15 (3) ◽  
pp. 184-197
Author(s):  
Gulshirin Charyyeva ◽  
◽  
Liudmila Tibekina ◽  
Olga Subbotina ◽  
◽  
...  
Keyword(s):  
Nervous System ◽  
Surgical Treatment ◽  
Literature Review ◽  
Natural Resistance ◽  
Living Standard ◽  
Differential Diagnostics ◽  
Considerable Influence ◽  
Definition Of ◽  
True Definition ◽  
Human Nervous System

Epilepsy is the most taking place disease of the human nervous system. Despite the fact that we are continuously introducing new medicines into therapy of this illness we still are failing to take control over seizures in 1/3 cases. Persisting seizures gain considerable influence on patients’ living standard and within children audience cause delays in person maturity. Given article shows deep analysis of the last years researches which gave background to discover main mechanisms of pharmacoresistance. The issues of pathophysiological features of medicine resistance and reasons of false diagnostics are as well discussed. Authors highlighted few pathologic conditions where applied differential diagnostics allowed to avoid diagnostical mistakes. True definition of the certain seizures features according to the up to date classification makes it possible for clinical staff to prescribe correct anticonvulsant therapy, so far diminishing the risk of pseudo resistance outcome of disease. The article introduces criteria of natural resistance which if being recognized allows to perform dew time surgical treatment and therefore cuts seizures in most of the cases.

scholarly journals The Anti-Neuroinflammatory Role of Anthocyanins and Their Metabolites for the Prevention and Treatment of Brain Disorders

2020 ◽  
Vol 21 (22) ◽  
pp. 8653
Author(s):  
Joana F. Henriques ◽  
Diana Serra ◽  
Teresa C. P. Dinis ◽  
Leonor M. Almeida
Keyword(s):  
Neurological Disorders ◽  
Fruits And Vegetables ◽  
Molecular Mechanisms ◽  
Brain Inflammation ◽  
Brain Diseases ◽  
Naturally Occurring ◽  
Pathological Conditions ◽  
Promising Strategy ◽  
Prevention And Treatment

Anthocyanins are naturally occurring polyphenols commonly found in fruits and vegetables. Numerous studies have described that anthocyanin-rich foods may play a crucial role in the prevention and treatment of different pathological conditions, which have encouraged their consumption around the world. Anthocyanins exhibit a significant neuroprotective role, mainly due to their well-recognized antioxidant and anti-inflammatory properties. Neuroinflammation is an intricate process relevant in both homeostatic and pathological circumstances. Since the progression of several neurological disorders relies on neuroinflammatory process, targeting brain inflammation has been considered a promising strategy in those conditions. Recent data have shown the anti-neuroinflammatory abilities of many anthocyanins and of their metabolites in the onset and development of several neurological disorders. In this review, it will be discussed the importance and the applicability of these polyphenolic compounds as neuroprotective agents and it will be also scrutinized the molecular mechanisms underlying the modulation of neuroinflammation by these natural compounds in the context of several brain diseases.

scholarly journals Predicting the risk of neurological complications in the erythemal form of ixodes Lyme disease

2016 ◽  
Vol 21 (6) ◽  
pp. 341-346
Author(s):  
D. Yu Moshkova ◽  
Marina G. Avdeeva
Keyword(s):  
Nervous System ◽  
Lyme Disease ◽  
Peripheral Nervous System ◽  
Lyme Borreliosis ◽  
Inflammatory Cytokine ◽  
Neurological Complications ◽  
Average Level ◽  
Pathogenetic Therapy ◽  
Chronic Course

The aim. The prediction of risk degrees of neurological complications in adult patients with erythemal form of borreliosis for the timely appointment of causal and pathogenetic therapy. Materials and methods. We observed 46 patients hospitalized in infectious hospital in Krasnodar in 2013-2014, with a diagnosis of Ixodes tick-borne Lyme disease, erythemal form, acute course was observed in 41 (89.1%) person, subacute - in 2 (4.4%), chronic - 3 (6.5%). In the course of the disease there was studied the level of pro-inflammatory cytokine IFN-y. Results. The average age of patients was 41.1 ± 1.83 years, among them women (63%) dominated. In 31% of patients there were observed symptoms of the damage of the nervous system. From the first week of the disease there was noted a significant increase in the level of IFN-y, which persisted both in the subacute and chronic course of the disease. The average level of IFN-y in patients with signs of the damage of the central and peripheral nervous system accounted for 64.8±14.19 pg/ml being ignificantly higher (P 20.0 pg/ml symptoms of the damage of the nervous system were recorded in 50% of cases. The degrees of neurological complications risk in patients with tick-borne Lyme disease are determined: the IFN-y level of 20.0-34.99 pg/ml predicted the risk of 1 degree (12.5%), level of 35,0-79,99 pg/ml - the risk of 2 degree (45%), the level higher than 80.0pg/ml - the risk of 3 degree (100%). Conclusion. The use of the determination of the IFN-y level can increase the accuracy and provide the timeliness of diagnosis of neurological complications in Lyme borreliosis cases, that is important for the prognosis and treatment of the disease.

scholarly journals Neurological manifestations and complications in patients with covid-19

2020 ◽  
Vol 7 (3) ◽  
pp. 21-29
Author(s):  
I. K. Ternovyh ◽  
M. P. Topuzova ◽  
A. D. Chaykovskaya ◽  
P. Sh. Isabekova ◽  
T. M. Alekseeva
Keyword(s):  
Nervous System ◽  
Neurological Diseases ◽  
Neurological Complications ◽  
Epidemiological Studies ◽  
Neurological Manifestations ◽  
Long Time ◽  
The Central Nervous System ◽  
Coronavirus Infection ◽  
Mechanisms Of Development ◽  
Large Groups

It becomes apparent that the neurological complications of COVID-19 are significantly common, but in some cases, establishing a causal relationship is difficult. For example, a stroke can occur for reasons unrelated to coronavirus infection, while Guillain–Barré syndrome and meningoencephalitis are likely to be a parainfection. Only long-term epidemiological studies in large groups of patients can clarify some of these issues. This will help to better understand the mechanisms of development of complications and develop schemes for their treatment and subsequent rehabilitation. The article presents the mechanisms of penetration of the coronavirus into the nervous system and systematizes the neurological manifestations and complications of COVID-19, which were described in the first 3 months of the pandemic. Particular attention is paid to the consideration of the complications of COVID-19 from the central and peripheral nervous system, the most interesting clinical examples are considered. Summing up the analysis of the literature, we can say that the clinical picture of neurological diseases and syndromes caused by coronavirus infection corresponds to the usual notions. Also considered is the assumption that SARS-CoV-2 can persist for a long time in the central nervous system in the form of inactive fragments, which means that it can recur in predisposed individuals when appropriate conditions arise. This suggestion is alarming regarding distant neurological complications in infected and cured patients.

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