Association between Stage and Degree of Differentiation with Ca-125 Levels and Inflammatory Response Markers in Malignant Serous Tumors of the Ovary

Abstract Background: This study attempts to evaluate whether preoperative systemic inflammatory response (SIR) markers or other hematological variables, such as albumin, D-dimer, and carbohydrate antigen 125, play roles in predicting chemotherapy response and survival outcome in patients with ovarian clear cell carcinoma (OCCC).Methods: Preoperative leukocyte differential counts, as well as platelet, serum albumin, plasma D-dimer and CA-125 levels, were measured in patients with FIGO IC-IV ovarian clear cell cancer. The correlations of these hematological biomarkers with clinicopathological features, chemotherapy response, and survival outcomes were further analyzed. Survival time was estimated using the Kaplan-Meier model, whereas Cox regression was conducted for multivariate analysis.Results: Among the 84 patients, 28.6% were classified as platinum resistant, and 69.0% were platinum sensitive. Preoperative CA125, albumin, and D-dimer levels; neutrophil to lymphocyte ratios (NLR); and monocyte to lymphocyte ratios were significantly correlated with FIGO stage, residual tumor, and platinum response. Platelet to lymphocyte ratio was not related to platinum response (P=0.060). The median follow-up time was 28 months (range, 1 to 128 months). Preoperative CA125, albumin, and D-dimer levels were significant prognostic factors for overall survival (OS) and progression-free survival (PFS). In the univariate analysis, only NLR exhibited prognostic significance for PFS (P = 0.007). Multivariate analysis indicated that D-dimer > 3.27 (P = 0.001 for OS; P = 0.040 for PFS) and albumin <39.6 (P = 0.005 for OS and P = 0.041 for PFS) retained significance.Conclusions: Preoperative NLR has some predictive value for platinum resistance in patients with IC-IV stage OCCC but has little predictive effect on prognosis. Elevated D-dimer and reduced albumin might be potential biomarkers for worse response to first-line platinum-based chemotherapy and poor clinical outcomes.

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Serum D-dimer, Albumin and Systemic Inflammatory Response Markers in Ovarian Clear Cell Carcinoma and Their Prognostic Implications

10.21203/rs.3.rs-16438/v1 ◽

2020 ◽

Author(s):

Wei Chen ◽

Siyuan Zhong ◽

Boer Shan ◽

Shuling Zhou ◽

Xiaohua Wu ◽

...

Keyword(s):

Inflammatory Response ◽

Cell Carcinoma ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Systemic Inflammatory Response ◽

Ca 125 ◽

Chemotherapy Response ◽

Ovarian Clear Cell Carcinoma ◽

Lymphocyte Ratio ◽

D Dimer

Abstract Background The study aims to evaluate whether preoperative systemic inflammatory response (SIR) markers or other hematologic variables, such as albumin, D-dimer, carbohydrate antigen 125 play a role in predicting chemotherapy response and survival outcome in patients with ovarian clear cell carcinoma (OCCC). Methods Preoperative leukocyte differential counts, platelet, serum albumin, plasma D-dimer and CA-125 levels were measured in patients with FIGO IC-IV ovarian clear cell cancer. The correlations of these hematologic biomarkers with clinicopathological features, chemotherapy response, and survival outcomes were further analyzed. Survival time was estimated using the Kaplan-Meier model, whereas Cox regression was conducted for multivariate analysis.Results Among the 84 patients, 28.6% were classified as platinum-resistant and 69.0% as platinum sensitive. Preoperative CA125, albumin, D-dimer, and neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio were significantly correlated with FIGO stage, residual tumor, and platinum response. Platelet to lymphocyte ratio was not related to platinum response ( P =0.060). The median follow-up time was 28 months (range, 1 to 128 months). Preoperative CA125, albumin, and D-dimer were significant prognostic factors for overall survival (OS) and progression-free survival (PFS). In the univariate analysis, only NLR had prognostic significance for PFS ( P =0.007). Multivariate analysis indicated that D-dimer > 3.27 ( P = 0.001 for OS; P = 0.040 for PFS) and albumin <39.6 ( P = 0.005 for OS and P = 0.041 for PFS) retained significance.Conclusions Preoperative NLR has some predictive value for platinum resistance in patients with IC-IV stage OCCC, but has little predictive effect on prognosis. Elevated D-dimer and reduced albumin might be potential biomarkers for worse response to first-line platinum-based chemotherapy and poor clinical outcomes.

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The Relationship Between Serum Levels Of CA- 125 and Interleukin -6 with the Degree of Differentiation in Ovarian Neoplasms

Annals of Pathology and Laboratory Medicine ◽

10.21276/apalm.2549 ◽

2019 ◽

Vol 6 (7) ◽

pp. A392-397

Author(s):

Minakshi Rajput ◽

◽

C. V. Kulkarni ◽

Ashok Yadav ◽

Sachin Sharma ◽

...

Keyword(s):

Interleukin 6 ◽

Ovarian Neoplasms ◽

Serum Levels ◽

Ca 125 ◽

Degree Of Differentiation ◽

The Relationship

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Systemic Inflammatory Response Markers and CA-125 Levels in Ovarian Clear Cell Carcinoma: A Two Center Cohort Study

Cancer Research and Treatment ◽

10.4143/crt.2014.324 ◽

2016 ◽

Vol 48 (1) ◽

pp. 250-258 ◽

Cited By ~ 25

Author(s):

Hee Seung Kim ◽

Hwa-Young Choi ◽

Maria Lee ◽

Dong Hoon Suh ◽

Kidong Kim ◽

...

Keyword(s):

Cohort Study ◽

Inflammatory Response ◽

Cell Carcinoma ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Systemic Inflammatory Response ◽

Ca 125 ◽

Ovarian Clear Cell Carcinoma

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Ultrastructure of mesotheliomas

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100110775 ◽

1984 ◽

Vol 42 ◽

pp. 98-101

Author(s):

Irving Dardick

Keyword(s):

Electron Microscopy ◽

Latent Period ◽

Spindle Cell ◽

Spindle Cell Sarcoma ◽

Metastatic Adenocarcinoma ◽

Cell Sarcoma ◽

Cytological Features ◽

Industrial Use ◽

Degree Of Differentiation

With the extensive industrial use of asbestos in this century and the long latent period (20-50 years) between exposure and tumor presentation, the incidence of malignant mesothelioma is now increasing. Thus, surgical pathologists are more frequently faced with the dilemma of differentiating mesothelioma from metastatic adenocarcinoma and spindle-cell sarcoma involving serosal surfaces. Electron microscopy is amodality useful in clarifying this problem.In utilizing ultrastructural features in the diagnosis of mesothelioma, it is essential to appreciate that the classification of this tumor reflects a variety of morphologic forms of differing biologic behavior (Table 1). Furthermore, with the variable histology and degree of differentiation in mesotheliomas it might be expected that the ultrastructure of such tumors also reflects a range of cytological features. Such is the case.

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