Daptomycin Versus Other Antimicrobial Agents for the Treatment of Skin and Soft Tissue Infections: A Meta-Analysis

2010 ◽  
Vol 44 (1) ◽  
pp. 97-106 ◽  
Author(s):  
loannis A Bliziotis ◽  
Eleni Plessa ◽  
George Peppas ◽  
Matthew E Falagas
Keyword(s):  
Soft Tissue ◽  
Antimicrobial Agents ◽  
Meta Analysis ◽  
Soft Tissue Infections

scholarly journals PIN1 A BAYESIAN META-ANALYSIS OF THE EFFICACY OF SIX ANTIMICROBIAL AGENTS FOR CONFIRMED STAPHYLOCOCCUS AUREUS COMPLICATED SKIN AND SOFT-TISSUE INFECTIONS (CSSTIS)

2008 ◽  
Vol 11 (6) ◽  
pp. A428
Author(s):  
JFS Logman ◽  
MJ Treur ◽  
BG Verheggen ◽  
BMS Heeg ◽  
J Stephens ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Antimicrobial Agents ◽  
Meta Analysis ◽  
Soft Tissue Infections ◽  
Complicated Skin

Linezolid versus vancomycin for MRSA skin and soft tissue infections (systematic review and meta-analysis)

2009 ◽  
Vol 79 (9) ◽  
pp. 629-635 ◽  
Author(s):  
Tristan John Dodds ◽  
Catherine Isobel Hawke
Keyword(s):  
Systematic Review ◽  
Soft Tissue ◽  
Meta Analysis ◽  
Soft Tissue Infections

scholarly journals Controlled and Local Delivery of Antibiotics by 3D Core/Shell Printed Hydrogel Scaffolds to Treat Soft Tissue Infections

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2151
Author(s):  
Ashwini Rahul Akkineni ◽  
Janina Spangenberg ◽  
Michael Geissler ◽  
Saskia Reichelt ◽  
Hubert Buechner ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Antimicrobial Agents ◽  
Release Kinetics ◽  
Core Shell ◽  
Burst Release ◽  
High Morbidity ◽  
Local Concentration ◽  
Soft Tissue Infections ◽  
Antibiotic Delivery

Soft tissue infections in open fractures or burns are major cause for high morbidity in trauma patients. Sustained, long-term and localized delivery of antimicrobial agents is needed for early eradication of these infections. Traditional (topical or systemic) antibiotic delivery methods are associated with a variety of problems, including their long-term unavailability and possible low local concentration. Novel approaches for antibiotic delivery via wound coverage/healing scaffolds are constantly being developed. Many of these approaches are associated with burst release and thus seldom maintain long-term inhibitory concentrations. Using 3D core/shell extrusion printing, scaffolds consisting of antibiotic depot (in the core composed of low concentrated biomaterial ink 3% alginate) surrounded by a denser biomaterial ink (shell) were fabricated. Denser biomaterial ink (composed of alginate and methylcellulose or alginate, methylcellulose and Laponite) retained scaffold shape and modulated antibiotic release kinetics. Release of antibiotics was observed over seven days, indicating sustained release characteristics and maintenance of potency. Inclusion of Laponite in shell, significantly reduced burst release of antibiotics. Additionally, the effect of shell thickness on release kinetics was demonstrated. Amalgamation of such a modular delivery system with other biofabrication methods could potentially open new strategies to simultaneously treat soft tissue infections and aid wound regeneration.

scholarly journals Role of topical nadifloxacin as an empirical treatment in patients with skin and soft-tissue infections in India: A review and consensus

2021 ◽  
Vol 1 ◽  
pp. 61
Author(s):  
Rashmi Sarkar ◽  
Sushil Tahiliani ◽  
Amit Madan ◽  
Anil Abraham ◽  
Anil Ganjoo ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Antimicrobial Agents ◽  
Efflux Pump ◽  
Empirical Treatment ◽  
Cochrane Library ◽  
Extensive Literature ◽  
Soft Tissue Infections ◽  
Topical Formulation ◽  
Topoisomerase Iv ◽  
Development Of Resistance

Dermatologists often come across cases of skin and soft-tissue infections (SSTIs) which have diverse clinical presentations. Various local, systemic, and environmental risk factors predispose an individual to develop SSTIs. Topical antimicrobial agents are frequently used in superficial uncomplicated SSTIs, whereas systemic therapy is generally reserved for use in severe cases. However, emergence of resistance to these agents is becoming a common problem in clinical practice. This necessitates the use of other classes of antimicrobials for the effective treatment of SSTIs. Nadifloxacin, a potential drug belonging to the fluoroquinolone group, has various advantages such as binding to bacterial DNA gyrase and topoisomerase IV enzymes, inhibition of nor-A efflux pump, survival in acidic pH, anti-MRSA activity, and biofilms penetration. It has also shown least development of resistance since its introduction. Although its topical formulation has shown superior efficacy as an anti-acne agent, there are no specific guidelines for its appropriate use in SSTIs. Hence, a panel of experts was formed, under whose guidance an extensive literature search was performed in MEDLINE, Cochrane Library, and Science Direct databases. Using the modified Delphi technique, the available evidence was reviewed and corresponding recommendations were given for the use of topical Nadifloxacin as an empirical treatment in SSTIs.

scholarly journals Hepatic disease and the risk of mortality of Vibrio vulnificus necrotizing skin and soft tissue infections: A systematic review and meta-analysis

PLoS ONE ◽  
2019 ◽  
Vol 14 (10) ◽  
pp. e0223513
Author(s):  
Po-Yao Chuang ◽  
Tien-Yu Yang ◽  
Tsan-Wen Huang ◽  
Yao-Hung Tsai ◽  
Kuo-Chin Huang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Soft Tissue ◽  
Vibrio Vulnificus ◽  
Meta Analysis ◽  
Hepatic Disease ◽  
Soft Tissue Infections ◽  
Risk Of Mortality

scholarly journals The safety and efficacy of daptomycin versus other antibiotics for skin and soft-tissue infections: a meta-analysis of randomised controlled trials

BMJ Open ◽  
2014 ◽  
Vol 4 (6) ◽  
pp. e004744-e004744 ◽  
Author(s):  
S. Z. Wang ◽  
J. T. Hu ◽  
C. Zhang ◽  
W. Zhou ◽  
X. F. Chen ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Soft Tissue Infections ◽  
Safety And Efficacy ◽  
Randomised Controlled

scholarly journals Antibiotic therapy for skin and soft tissue infections: a protocol for a systematic review and network meta-analysis

2018 ◽  
Vol 7 (1) ◽  
Author(s):  
Jessica J. Bartoszko ◽  
Dominik Mertz ◽  
Lehana Thabane ◽  
Mark Loeb
Keyword(s):  
Systematic Review ◽  
Soft Tissue ◽  
Antibiotic Therapy ◽  
Meta Analysis ◽  
Soft Tissue Infections

Global patterns of necrotizing soft tissue infections: A systematic review and meta-analysis

Surgery ◽  
2021 ◽  
Author(s):  
Chathurika S. Dhanasekara ◽  
Brianna Marschke ◽  
Erin Morris ◽  
Chanaka N. Kahathuduwa ◽  
Sharmila Dissanaike
Keyword(s):  
Systematic Review ◽  
Soft Tissue ◽  
Meta Analysis ◽  
Soft Tissue Infections ◽  
Necrotizing Soft Tissue Infections ◽  
Global Patterns
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