scholarly journals Tumor Morphology and Immunohistochemical Expression of Estrogen Receptor, Progesterone Receptor, p53, and Ki67 in Urogenital Carcinomas of California Sea Lions (Zalophus californianus)

2009 ◽  
Vol 46 (4) ◽  
pp. 642-655 ◽  
Author(s):  
K. M. Colegrove ◽  
F. M. D. Gullanda ◽  
D. K. Naydan ◽  
L. J. Lowenstine
Keyword(s):  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Intraepithelial Neoplasia ◽  
Metastatic Carcinoma ◽  
Receptor Expression ◽  
Epithelial Dysplasia ◽  
California Sea Lions ◽  
P53 Expression ◽  
Sea Lions ◽  
Intraepithelial Lesions

Metastatic carcinoma of urogenital origin is a common cause of mortality in free-ranging California sea lions (Zalophus californianus). The etiology of this cancer is likely multifactorial, with viral infection, genetic factors, and exposure to environmental organochlorine contaminants possible contributing factors. In this study, expression of estrogen receptor α (ER α), progesterone receptor (PR), p53, and Ki67 were evaluated by immunohistochemistry in 12 sea lions with metastatic carcinoma, genital epithelial dysplasia, and intraepithelial neoplasia; 4 with genital epithelial dysplasia and intraepithelial neoplasia without metastases; and 6 control animals. Dysplastic and neoplastic lesions were identified in multiple areas of the cervix, vagina, penis, prepuce, and urethra in affected animals, suggesting multicentric development. Lesions were graded according to degree of epithelial dysplasia and infiltration and lesions of different grades were evaluated separately. Estrogen receptor expression was lower in intraepithelial lesions compared with normal genital epithelium, and expression in metastatic lesions was completely absent. There was progesterone receptor expression in neoplastic cells in intraepithelial lesions of all grades and in metastases, with no significant difference between lesion grades or between control and affected epithelium. Ki67 index and p53 expression increased with lesion grade and were higher in lesions than normal epithelium. Metastatic tumors exhibited highly variable morphology; however, proliferation index, ER α, PR, and p53 expression were similar in tumors with different patterns of growth. These results suggest that endogenous hormones, environmental contaminants that interact with steroid hormone receptors, and alterations in p53 may play a role in urogenital carcinogenesis in California sea lions.

scholarly journals Ki-67 Expression is a Significant Prognostic Factor Only When Progesterone Receptor Expression is Low in Estrogen Receptor-Positive and HER2-Negative Early Breast Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Young-Joon Kang ◽  
Han-Byoel Lee ◽  
Yun Gyoung Kim ◽  
JaiHong Han ◽  
Yumi Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Prognostic Factor ◽  
Progesterone Receptor ◽  
Cancer Patients ◽  
Early Breast Cancer ◽  
Receptor Expression ◽  
Breast Cancer Patients ◽  
Ki 67 ◽  
End Point

Objective. While the value of Ki-67 has been recognized in breast cancer, controversy also exists. The goal of this study is to show the prognostic value of Ki-67 according to progesterone receptor (PgR) expression in patients who have estrogen receptor- (ER-) positive, human epidermal growth factor receptor 2- (HER2-) negative early breast cancer. Methods. The records of nonmetastatic invasive breast cancer patients who underwent surgery at a single institution between 2009 and 2012 were reviewed. Primary end point was recurrence-free survival (RFS), and secondary end point was overall survival (OS). Ki-67 and PgR were assessed with immunohistochemistry for the tumor after surgery. Results. A total of 1848 patients were enrolled in this study. 223 (12%) patients had high (≥10%) Ki-67, and 1625 (88%) had low Ki-67 expression. Significantly worse RFS and OS were observed in the high vs. low Ki-67 expression only when the PgR was low (<20%) (p<0.001 and 0.005, respectively, for RFS and OS). There was no significant difference in RFS and OS according to Ki-67 when the PgR was high (p=0.120 and 0.076). RFS of four groups according to high/low Ki-67 and PgR expression was compared. The low PgR and high Ki-67 expression group showed worst outcome among them (p<0.001). In a multivariate analysis, high Ki-67 was an independent prognostic factor when the PgR was low (HR 3.05; 95% CI 1.50–6.19; p=0.002). Conclusions. Ki-67 had a value as a prognostic factor only under low PgR expression level in early breast cancer. PgR should be considered in evaluating the prognosis of breast cancer patients using Ki-67.

scholarly journals Estrogen Receptor, Progesterone Receptor and Glucocorticoid Receptor Expression in Normal Myometrium and in Leomyoma

2017 ◽  
Vol 1 (2) ◽  
Keyword(s):  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Glucocorticoid Receptor ◽  
Uterine Leiomyoma ◽  
Receptor Expression ◽  
Therapeutic Action ◽  
Estrogen Sulfotransferase ◽  
Smooth Muscle Tumour ◽  
Significant Difference ◽  
Expression Status

Uterine leiomyoma is the most common benign smooth muscle tumour that originates from the myometrium. Ovarian sex steroids are responsible for the growth of such tumours, though estrogen and progesterone are not the only modulators involved in the tumourigenesis and growth of leiomyomata. The activation of glucocorticoid receptor (GR) can induce the expression and activity of estrogen sulfotransferase, an enzyme that generally inactivates estrogen, because of the effects of sulfonated estrogen fails to activate the estrogen receptor, it is of interest to know whether GR is present or not in leiomyomata and in the normal myometrium. The aim of this study is to analyse the expression of GR in leiemyoma and myometrium. Method: The immunohistochemistry of 47 patients was tested to find the expression status of estrogen receptor (ER), progesterone receptor (PR) and GR in leiemyoma and normal myometrium. Results: GR, ER and PR were expressed in both normal myometrium and in leiomyoma. There was a significant difference in the expression of GR found in normal myometrium compared with those expressed in leiomyoma (Allred Score, 256±29 versus 91 ±23). The GR expressed was significantly lower than the ER and PR expressed in leiomyoma. Conclusion: This presence of GR in the normal myometrium and in myomas is interesting and could be used for therapeutic action. But, first, the roles of G on myomas have to be understand.

Sex differences in progesterone receptor immunoreactivity in neonatal mouse brain depend on estrogen receptor ? expression

2001 ◽  
Vol 47 (3) ◽  
pp. 176-182 ◽  
Author(s):  
Christine K. Wagner ◽  
Jennifer L. Pfau ◽  
Geert J. De Vries ◽  
Istvan J. Merchenthaler
Keyword(s):  
Estrogen Receptor ◽  
Sex Differences ◽  
Progesterone Receptor ◽  
Mouse Brain ◽  
Neonatal Mouse ◽  
Receptor Expression ◽  
Estrogen Receptor Expression
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