Fluorescence Lifetime Study of Cyclodextrin Complexes of Substituted Naphthalenes

1987 ◽  
Vol 41 (7) ◽  
pp. 1235-1238 ◽  
Author(s):  
Gregory Nelson ◽  
Gabor Patonay ◽  
Isiah M. Warner
Keyword(s):  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Fluorescence Lifetime ◽  
Fluorescence Decay ◽  
Cyclodextrin Complexes ◽  
Naphthalene Derivatives ◽  
Lifetime Measurements ◽  
Total Fluorescence

The interactions of α, β, and -γ-cyclodextrins and selected naphthalene derivatives as observed through fluorescence lifetime measurements are discussed in detail. These systems can be quickly characterized with the use of the parameters obtained from experimental fluorescence decay curves. The formation of inclusion complexes can be followed with the appearance of a long-lived fluorophore which contributes to the total fluorescence according to the cyclodextrin concentration. This fluorophore is determined to be an inclusion complex between a naphthalene and cyclodextrin.

scholarly journals Solution inclusion complexes of cyclodextrins with sodium perfluorooctanoate

1989 ◽  
Vol 67 (10) ◽  
pp. 1550-1553 ◽  
Author(s):  
Ramamurthy Palepu ◽  
Vincent C. Reinsborough
Keyword(s):  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Goodness Of Fit ◽  
Sodium Ion ◽  
The Other ◽  
Cyclodextrin Complexes ◽  
Fluorocarbon Surfactant ◽  
Other Hand ◽  
Fluorocarbon Chain ◽  
Sodium Perfluorooctanoate

Pre-micellar and micellar sodium perfluorooctanoate solutions (SPFO) were examined conductometrically with added α-cyclodextrin(α-CD), β-cyclodextrin (β-CD), and γ-cyclodextrin (γ-CD). The order of stability of the 1:1 inclusion complex was (β-CD > γ-CD > α-CD determined largely by the goodness of fit of the fluorocarbon chain in the CD cavity. Sodium ion electrode studies revealed that some Na+ ion is associated with the (β-CD/SPFO complex. As shown by fluorine-19 nmr, (β-CD girds the SPFO molecule snugly amidship with the terminal CF3 group still in solution. On the other hand, SPFO manages only a weak penetration of the fluorocarbon chain into the smaller α-CD cavity. Keywords: perflurooctanoate, cyclodextrin complexes, fluorocarbon surfactant, 19F nmr.

Studies of Chiral Modifiers on γ-Cyclodextrin-Pyrene Complexes Using Fluorescence Lifetime Measurements

1995 ◽  
Vol 49 (12) ◽  
pp. 1762-1765 ◽  
Author(s):  
A. Yvette Will ◽  
Jodi M. Schuette-Parsons ◽  
Rezik A. Agbaria ◽  
Isiah M. Warner
Keyword(s):  
Inclusion Complexes ◽  
Fluorescence Lifetime ◽  
Pure Water ◽  
Formation Constants ◽  
Chiral Alcohols ◽  
Lifetime Measurements

This work focuses on the inclusion complexes of γ-cyclodextrin and pyrene as indicated by fluorescence lifetime analyses and the influences of chiral alcohols and diols on these complexes. The 2-butanol participates in the γ-cyclodextrin-pyrene complexation and produces a longer lifetime of complexed pyrene than the value determined for the complex in pure water. The enantiomeric 1,3-butanediol also produces a longer lifetime of complexed pyrene. However, a decrease in this lifetime is observed in the presence of racemic 1,3-butanediol. This study also involves an estimation of formation constants for γ-cyclodextrin-pyrene complexes by use of the fluorescence lifetime measurements.

NMR Studies of the Inclusion Complexes Between Ezetimibe and Cyclodextrins

2018 ◽  
Vol 69 (7) ◽  
pp. 1838-1841
Author(s):  
Hajnal Kelemen ◽  
Angella Csillag ◽  
Bela Noszal ◽  
Gabor Orgovan
Keyword(s):  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Water Solubility ◽  
Solution Nmr ◽  
Spectroscopic Techniques ◽  
Nmr Studies ◽  
The Poor ◽  
Poor Water Solubility

Ezetimibe, the antihyperlipidemic drug of poor bioavailability was complexed with native and derivatized cyclodextrins.The complexes were characterized in terms stability, stoichiometry and structure using various 1D and 2D solution NMR spectroscopic techniques. The complexes were found to be of moderate stability (logK[3). The least stable inclusion complex is formed with b-cyclodextrin, while the ezetimibe-methylated-b--cyclodextrin has a 7-fold higher stability. The results can be useful to improve the poor water-solubility and the concomitant bioavailability of ezetimibe.

scholarly journals The guest polymer effect on the dissolution of drug–polymer crystalline inclusion complexes

RSC Advances ◽  
2021 ◽  
Vol 11 (22) ◽  
pp. 13091-13096
Author(s):  
Lu Chen ◽  
Yanbin Huang
Keyword(s):  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Significant Influence ◽  
Crystalline Inclusion ◽  
Complex Crystals

Guest polymers have significant influence on the dissolution of drug–polymer inclusion complex crystals.

Fluorescence Lifetime Measurements and Spectral Analysis of Adamantyldiazirine

1997 ◽  
Vol 119 (15) ◽  
pp. 3580-3591 ◽  
Author(s):  
Jeffrey S. Buterbaugh ◽  
John P. Toscano ◽  
William L. Weaver ◽  
James R. Gord ◽  
Christopher M. Hadad ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
Fluorescence Lifetime ◽  
Lifetime Measurements

Mn4+ non-equivalent doped fluoride phosphor towards a short fluorescence decay time for backlighting

2022 ◽  
Author(s):  
Jie Li ◽  
Xinyi Yang ◽  
Tong Li ◽  
Yan-Qing Ye ◽  
Yayun Zhou ◽  
...  
Keyword(s):  
Ion Exchange ◽  
Fluorescence Lifetime ◽  
Decay Time ◽  
Fluorescence Decay ◽  
Compensation Mechanism ◽  
Exchange Method ◽  
Fluorescence Decay Time ◽  
Ion Exchange Method

The non-equivalent doping of Mn4+ in the red-emitting fluoride phosphors effectively shortens the fluorescence lifetime. Herein, we successfully synthesized Rb2NaInF6:Mn4+ phosphors by an ion-exchange method. The compensation mechanism of Mn4+...

scholarly journals Preparation, characterization and featuring of an inclusion complex of nerol with β-cyclodextrin

2017 ◽  
Vol 5 (2) ◽  
pp. 195
Author(s):  
Mayara Coêlho ◽  
Herlane Da Silva ◽  
Muhammad Islam ◽  
Vicente Viana ◽  
Ana Amélia Melo-Cavalcante
Keyword(s):  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Biological Activities ◽  
Aqueous Media ◽  
Limiting Factor ◽  
Thermo Gravimetric ◽  
Drug Molecules ◽  
Complex Cavity ◽  
Nonpolar Molecules ◽  
Low Solubility

Nerol is an acyclic type monoterpene with important biological activities. However, the low solubility in aqueous media is a limiting factor for its user. Cyclodextrins have been widely used in order to improve the solubility, stability and bioavailability of nonpolar molecules through the formation of inclusion complexes. Thus, the present study consists in the development of nerol inclusion complex in combination with the β-cyclodextrin (β-CD) followed by characterizing by thermal analysis and spectrophotometric absorption in the infrared (FTIR). The results suggest a complexation of nerol with β-CD having detours and changed the intensity of various bands. The thermo gravimetric curve of CI found to indicate an output of solvating water molecules from the complex cavity formed for replacement of drug molecules probably included. Thus, it is concluded a possibility to obtain inclusion complexes of nerol monoterpene with β-CD, which will increase its solubility and facilitate delivery process.

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