scholarly journals First-trimester NRBC Count in Maternal Circulation: Correlation with Doppler Ultrasound Studies

2005 ◽  
Vol 53 (3) ◽  
pp. 315-317
Author(s):  
Ariadni Mavrou ◽  
Aggeliki Kolialexi ◽  
Athena Souka ◽  
Athanasios Pilalis ◽  
Yannis Kavalakis ◽  
...  
Keyword(s):  
Blood Flow ◽  
High Resistance ◽  
First Trimester ◽  
Maternal Circulation ◽  
Arterial Perfusion ◽  
Uterine Arteries ◽  
Nucleated Red Blood Cells ◽  
High Impedance ◽  
First Trimester Of Pregnancy ◽  
Doppler Indices

This study aimed to determine whether the number of nucleated red blood cells (NRBCs) in maternal circulation during the first trimester of pregnancy could identify pregnancies that will have an anomalous Doppler in the second trimester. A total of 85 blood samples were obtained at 11–14 weeks of gestation with mean uterine arterial perfusion index >1.6, as noted by Doppler ultrasonography. NRBCs were enriched by magnetic automated cell sorting using anti-CD71 and were stained with May/Grunwald/Giemsa. A total of 4.8 NRBCs (range 1–75) were identified in 68 cases. Follow-up scans at 22–24 weeks were available in 46 cases. In 39 women, blood flow in the uterine arteries normalized, whereas in seven, high resistance was noted. One woman in the high-resistance group developed preeclampsia (PET; four NRBCs) and another delivered an intrauterine growth restriction (IUGR) baby (75 NRBCs). The number of NRBCs in women whose Doppler indices later normalized and in those who continued to have increased impedance was similar. The study indicates that NRBC number in maternal circulation during the first trimester cannot be used to screen pregnancies at high risk for developing preeclampsia (PET)/IUGR. High-impedance blood flow in the uterine arteries in the first trimester may be due to an unfinished process of trophoblastic invasion, most likely to be completed successfully by 22–24 weeks.

Diagnostic role of uterine artery dopplerometry in the first trimester of pregnancy

2021 ◽  
Vol 50 (4) ◽  
pp. 25-28
Author(s):  
V. I. Orlov ◽  
A. V. Orlov ◽  
T. A. Zamanskaya ◽  
T. V. Podolskaya
Keyword(s):  
Blood Flow ◽  
First Trimester ◽  
Uterine Blood Flow ◽  
Sonographic Examination ◽  
New Approach ◽  
Uterine Arteries ◽  
Diagnostic Role ◽  
Threatened Abortion ◽  
First Trimester Of Pregnancy

A Doppler sonographic examination of blood flow in the left and right uterine arteries was carried out in women in the first trimester of pregnancy. Systolic- diastolic ratio (S/D) andpulsative index (PI) were assessed in 71 women with physiological course of pregnancy and in 49 women with threatened abortion. The investigation revealed clear connection of the uterine blood flow lateralization and corpus luteum localization. These interrelations are characterized differently in case of physiological pregnancy and threatened abortion. The new approach to the evaluation of uterine blood flow gives an ability ofpreclinical diagnostics of threatened abortion.

Ductus venosus revisited: A Doppler blood flow evaluation in the first trimester of pregnancy

1997 ◽  
Vol 23 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Nuno Montenegro ◽  
Alexandra Matias ◽  
JoséCarlos Areias ◽  
Henrique Barros
Keyword(s):  
Blood Flow ◽  
First Trimester ◽  
Ductus Venosus ◽  
First Trimester Of Pregnancy ◽  
Blood Flow Evaluation

Predicting small for gestational age in the first trimester of pregnancy using maternal ophthalmic artery Doppler indices

2015 ◽  
Vol 29 (7) ◽  
pp. 1190-1194 ◽  
Author(s):  
Júlio Augusto Gurgel Alves ◽  
Sammya Bezerra Maia e Holanda Moura ◽  
Edward Araujo Júnior ◽  
Gabriele Tonni ◽  
Wellington P. Martins ◽  
...  
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Ophthalmic Artery ◽  
First Trimester ◽  
First Trimester Of Pregnancy ◽  
Doppler Indices

Ultrasound diagnosis of endometritis: hemodynamic features of the uterus

2019 ◽  
Vol 22 (6) ◽  
pp. 82-96
Author(s):  
I. A. Ozerskaya ◽  
A. A. Semiletova ◽  
G. G. Kazaryan
Keyword(s):  
Blood Flow ◽  
Comparison Group ◽  
Reproductive Age ◽  
Flow Index ◽  
Color Mapping ◽  
Arterial Perfusion ◽  
Uterine Arteries ◽  
Vascular Flow ◽  
Spectral Doppler ◽  
Vascularization Index

Objective.To determine the characteristics of hemodynamics of the uterus with endometritis.Material and methods.A retrospective analysis of 420 patients of reproductive age (19–53 years old) diagnosed with endometritis. The comparison group consisted of 323 women aged 17–52 without gynecological pathology.Blood flow indicators in the uterine arteries, such as maximum systolic, end-diastolic, and average blood flow velocity (Vmax, Vmin, Vmean), were estimated, and an arterial perfusion index (API) was calculated. With 3D reconstruction of the uterus in angioregime, a vascularization index (VI), a flow index (FI) and a vascular flow index (VFI) of the uterus and endometrium were obtained.Result.An increase in Vmax, Vmin, Vmean, as well as VI, VFI of the uterus and VI, FI and VFI of the endometrium in the early and middle proliferative phase of the cycle. API had monotonous values, but it should be taken into account in conjunction with VI.Conclusions.Echography combined with color mapping, spectral Doppler graphics and vascularization index determination using 3D in angio mode is a highly effective method for the diagnosis of endometritis. Characteristic changes in hemodynamics in endometritis manifest as a violation of the venous outflow in the uterus and, especially, in the endometrium, in the presence of hypervascu larization according to data VI in the aggregate of regulatory or reduced indicators of API.

scholarly journals Human Placenta Exosomes: Biogenesis, Isolation, Composition, and Prospects for Use in Diagnostics

2021 ◽  
Vol 22 (4) ◽  
pp. 2158 ◽  
Author(s):  
Evgeniya E. Burkova ◽  
Sergey E. Sedykh ◽  
Georgy A. Nevinsky
Keyword(s):  
Fetal Development ◽  
Biochemical Composition ◽  
First Trimester ◽  
Maternal Blood ◽  
Target Cells ◽  
Normal Functioning ◽  
Maternal Circulation ◽  
Placental Dysfunction ◽  
Bioactive Proteins ◽  
First Trimester Of Pregnancy

Exosomes are 40–100 nm nanovesicles participating in intercellular communication and transferring various bioactive proteins, mRNAs, miRNAs, and lipids. During pregnancy, the placenta releases exosomes into the maternal circulation. Placental exosomes are detected in the maternal blood even in the first trimester of pregnancy and their numbers increase significantly by the end of pregnancy. Exosomes are necessary for the normal functioning of the placenta and fetal development. Effects of exosomes on target cells depend not only on their concentration but also on their intrinsic components. The biochemical composition of the placental exosomes may cause various complications of pregnancy. Some studies relate the changes in the composition of nanovesicles to placental dysfunction. Isolation of placental exosomes from the blood of pregnant women and the study of protein, lipid, and nucleic composition can lead to the development of methods for early diagnosis of pregnancy pathologies. This review describes the biogenesis of exosomes, methods of their isolation, analyzes their biochemical composition, and considers the prospects for using exosomes to diagnose pregnancy pathologies.

scholarly journals The Correlation Between Abnormal Uterine Artery Flow in the First Trimester and Genetic Thrombophilic Alteration: A Prospective Case-Controlled Pilot Study

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 654
Author(s):  
Natalija Vedmedovska ◽  
Diana Bokucava ◽  
Anda Kivite-Urtane ◽  
Vita Rovite ◽  
Liene Zake-Nikitina ◽  
...  
Keyword(s):  
Blood Flow ◽  
Uterine Artery ◽  
Matched Control ◽  
First Trimester ◽  
Flow Patterns ◽  
Uterine Arteries ◽  
Sequence Variations ◽  
Artery Flow ◽  
Blood Flow Patterns ◽  
Singleton Pregnancies

Introduction. Evaluation of the first trimester uterine artery flow can predict the development of obstetrical complications. A genotype, making women prone to microthrombi. constitutes the main known susceptibility factor for anomalous development of placenta. Our aim was to study whether polymorphisms of 10 genes leading to blood clotting abnormalities are related to abnormal uterine artery blood flow in the first trimester, and may predict placenta-related diseases. Material and methods. In primary analyses we included 19 singleton pregnancies with abnormal blood flow in the uterine arteries during the first trimester of gestation, and 24 matched control with normal flow patterns. All patients were genotyped for sequence variations in F5, F2, F11, MTHFR, SERPINE-1, CYP4V2, SELE, GP6, angiotensinogen (AGT) and fibrinogen gamma (FGG) genes and followed up until delivery. Results. There were no differences between groups regarding selected sequence variations in any of these genes. The co-occurrence of several polymorphisms in the same patient was also not related to the blood flow patterns in the uterine arteries. Conclusions. Although we found certain trends of genetic polymorphisms being related to preeclampsia and fetal growth, we failed to find an association between clotting gene polymorphisms, single or in combination, with the abnormal uterine flow in the first trimester.

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