scholarly journals Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome

PLoS Genetics ◽  
2020 ◽  
Vol 16 (2) ◽  
pp. e1008300
Author(s):  
Terren K. Niethamer ◽  
Teng Teng ◽  
Melanie Franco ◽  
Yu Xin Du ◽  
Christopher J. Percival ◽  
...  
Genetics ◽  
1996 ◽  
Vol 144 (2) ◽  
pp. 511-521 ◽  
Author(s):  
Dorina Avram ◽  
Alan T Bakalinsky

Abstract An ssu2 mutation in Sacccharomyces cermisiae, previously shown to cause sulfite sensitivity, was found to be allelic to GRR1, a gene previously implicated in glucose repression. The suppressor rgt1, which suppresses the growth defects of grr1 strains on glucose, did not fully suppress the sensitivity on glucose or nonglucose carbon sources, indicating that it is not strictly linked to a defect in glucose metabolism. Because the Cln1 protein was previously shown to be elevated in grr1 mutants, the effect of CLN1 overexpression on sulfite sensitivity was investigated. Overexpression in GRR1 cells resulted in sulfite sensitivity, suggesting a connection between CLN1 and sulfite metabolism. Multicopy FZF1, a putative transcription factor, was found to suppress the sulfite sensitive phenotype of grr1 strains, but not the glucose derepression or aberrant cell morphology. Multicopy FZF1 was also found to suppress the sensitivity of a number of other unrelated sulfite-sensitive mutants, but not that of ssu1 or met20, implying that FZF1 may act through Ssulp and Met20p. Disruption of FZF1 resulted in sulfite sensitivity when the construct was introduced in single copy at the FZF1 locus in a GRR1 strain, providing evidence that FZF1 is involved in sulfite metabolism.


Nature ◽  
1959 ◽  
Vol 183 (4668) ◽  
pp. 1101-1104 ◽  
Author(s):  
A. A. EDDY ◽  
D. H. WILLIAMSON

2020 ◽  
Vol 640 ◽  
pp. A57 ◽  
Author(s):  
C. E. Alissandrakis ◽  
A. Nindos ◽  
T. S. Bastian ◽  
S. Patsourakos

Observations of the Sun at millimeter wavelengths with the Atacama Large Millimeter/submillimeter Array (ALMA) offer a unique opportunity to investigate the temperature structure of the solar chromosphere. In this article we expand our previous work on modeling the chromospheric temperature of the quiet Sun, by including measurements of the brightness temperature in the network and cell interiors, from high-resolution ALMA images at 3 mm (Band 3) and 1.26 mm (Band 6). We also examine the absolute calibration of ALMA full-disk images. We suggest that the brightness temperature at the center of the solar disk in Band 6 is ∼440 K above the value recommended by White et al. (2017, Sol. Phys., 292, 88). In addition, we give improved results for the electron temperature variation of the average quiet Sun with optical depth and the derived spectrum at the center of the disk. We found that the electron temperature in the network is considerably lower than predicted by model F of Fontenla et al. (1993, ApJ, 406, 319) and that of the cell interior considerably higher than predicted by model A. Depending on the network/cell segregation scheme, the electron temperature difference between network and cell at τ = 1 (100 GHz) ranges from ∼660 K to ∼1550 K, compared to ∼3280 K predicted by the models; similarly, the electron temperature, Te ratio ranges from ∼1.10 to 1.24, compared to ∼1.55 of the model prediction. We also found that the network/cell Te(τ) curves diverge as τ decreases, indicating an increase of contrast with height and possibly a steeper temperature rise in the network than in the cell interior.


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