scholarly journals Characterization of Regional Influenza Seasonality Patterns in China and Implications for Vaccination Strategies: Spatio-Temporal Modeling of Surveillance Data

PLoS Medicine ◽  
2013 ◽  
Vol 10 (11) ◽  
pp. e1001552 ◽  
Author(s):  
Hongjie Yu ◽  
Wladimir J. Alonso ◽  
Luzhao Feng ◽  
Yi Tan ◽  
Yuelong Shu ◽  
...  
2021 ◽  
Vol 10 (3) ◽  
pp. 188
Author(s):  
Cyril Carré ◽  
Younes Hamdani

Over the last decade, innovative computer technologies and the multiplication of geospatial data acquisition solutions have transformed the geographic information systems (GIS) landscape and opened up new opportunities to close the gap between GIS and the dynamics of geographic phenomena. There is a demand to further develop spatio-temporal conceptual models to comprehensively represent the nature of the evolution of geographic objects. The latter involves a set of considerations like those related to managing changes and object identities, modeling possible causal relations, and integrating multiple interpretations. While conventional literature generally presents these concepts separately and rarely approaches them from a holistic perspective, they are in fact interrelated. Therefore, we believe that the semantics of modeling would be improved by considering these concepts jointly. In this work, we propose to represent these interrelationships in the form of a hierarchical pyramidal framework and to further explore this set of concepts. The objective of this framework is to provide a guideline to orient the design of future generations of GIS data models, enabling them to achieve a better representation of available spatio-temporal data. In addition, this framework aims at providing keys for a new interpretation and classification of spatio-temporal conceptual models. This work can be beneficial for researchers, students, and developers interested in advanced spatio-temporal modeling.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Giulia Tedeschi ◽  
Lorenzo Scipioni ◽  
Maria Papanikolaou ◽  
Geoffrey W. Abbott ◽  
Michelle A. Digman

AbstractVoltage-gated potassium (Kv) channels are a family of membrane proteins that facilitate K+ ion diffusion across the plasma membrane, regulating both resting and action potentials. Kv channels comprise four pore-forming α subunits, each with a voltage sensing domain, and they are regulated by interaction with β subunits such as those belonging to the KCNE family. Here we conducted a comprehensive biophysical characterization of stoichiometry and protein diffusion across the plasma membrane of the epithelial KCNQ1-KCNE2 complex, combining total internal reflection fluorescence (TIRF) microscopy and a series of complementary Fluorescence Fluctuation Spectroscopy (FFS) techniques. Using this approach, we found that KCNQ1-KCNE2 has a predominant 4:4 stoichiometry, while non-bound KCNE2 subunits are mostly present as dimers in the plasma membrane. At the same time, we identified unique spatio-temporal diffusion modalities and nano-environment organization for each channel subunit. These findings improve our understanding of KCNQ1-KCNE2 channel function and suggest strategies for elucidating the subunit stoichiometry and forces directing localization and diffusion of ion channel complexes in general.


2021 ◽  
pp. 116927
Author(s):  
Bruna de Ramos ◽  
Melanie Vianna Alencar ◽  
Fábio Lameiro Rodrigues ◽  
Ana Luzia de Figueiredo Lacerda ◽  
Maíra Carneiro Proietti

2012 ◽  
Vol 204-208 ◽  
pp. 2721-2725
Author(s):  
Hua Ji Zhu ◽  
Hua Rui Wu

Village land continually changes in the real world. In order to keep the data up-to-date, data producers need update the data frequently. When the village land data are updated, the update information must be dispensed to the end-users to keep their client-databases current. In the real world, village land changes in many forms. Identifying the change type of village land (i.e. captures the semantics of change) and representing them in the data world can help end-users understand the change commonly and be convenient for end-users to integrate these change information into their databases. This work focuses on the model of the spatio-temporal change. A three-tuple model CAR for representing the spatio-temporal change is proposed based on the village land feature set before change and the village land feature set after change, change type and rules. In this model, the C denotes the change type. A denotes the attribute set; R denotes the judging rules of change type. The rule is described by the IF-THEN expressions. By the operations between R and A, the C is distinguished. This model overcomes the limitations of current methods. And more, the rules in this model can be easy realized in computer program.


2008 ◽  
Vol 41 (1) ◽  
pp. 204-216 ◽  
Author(s):  
T. Xiang ◽  
M.K.H. Leung ◽  
S.Y. Cho

2021 ◽  
Vol 58 (2) ◽  
pp. 281-299
Author(s):  
Somnath Bar ◽  
Bikash Ranjan Parida ◽  
Gareth Roberts ◽  
Arvind Chandra Pandey ◽  
Prasenjit Acharya ◽  
...  

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