scholarly journals Hyperglycemia associated with Chagas disease

2022 ◽  
Vol 3 (6) ◽  
pp. 1-5
Author(s):  
Imelda Menchaca Armenta ◽  
Antonio E. Gutiérrez Rodríguez ◽  
Hortencia Cortes Pérez ◽  
Jessica Zaragoza Cortes ◽  
Karen Zamora Cerritos
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Screening Test ◽  
Enzyme Linked Immunosorbent Assay ◽  
Chi Square ◽  
Long Term Follow Up ◽  
Chi Square Test ◽  
Years Lived With Disability

Chagas disease and type 2 diabetes mellitus are the two main causes of Years Lived with Disability. The consequences and possible interaction between both illnesses have been scarcely studied. A population study of blood donors from the Centro Estatal de Transfusión Sanguinea (CETS) was carried out with a reagent related to the Chagas test. Detection was carried out with an enzyme-linked immunosorbent assay (ELISA) of anti- Trypanosoma cruzi antibodies and also, an HbA1C test was performed with 4 mL of whole blood. Descriptive statistics were used to analyze quantitative and qualitative data. The Chi-square test was applied to determine the existence of an association between hyperglycemia and Chagas disease. A total of 4,952 participants were screened. All of the participants (100%) were from Hidalgo State and did not have a chagoma as evidence of having been bitten or denied contact with a “kissing bug”. Of the total, 26 reacted to the first screening test to detect anti-Trypanosoma cruzi antibodies; of these, five were confirmed as positive on the second screening test. The seroprevalence of T. cruzi was 0.01%. The results do not show a clear association but the frequency of hyperglycemia in population with Chagas coincides with that reported by other authors. Considering the scarce clinical–epidemiological evidence between Chagas disease, obesity, and hyperglycemia, long-term follow up of both morbidities is an area of opportunity for clinical and epidemiological study of T. cruzi reactivity.

scholarly journals Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole

2020 ◽  
Vol 14 (9) ◽  
pp. e0008726
Author(s):  
Claudia Magalhães Calvet ◽  
Tatiana Araújo Silva ◽  
Diane Thomas ◽  
Brian Suzuki ◽  
Ken Hirata ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Long Term Follow Up ◽  
Cruzi Infection

P3747Does pulmonary vein isolation have similar results for treating AF in Chagas disease?

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
P Macedo ◽  
P Rueda ◽  
L Serafim ◽  
E Oliveira ◽  
S Santos ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Binary Logistic Regression ◽  
Long Term Results ◽  
Categorical Variables ◽  
Chi Square ◽  
Af Ablation ◽  
Predictors Of Recurrence ◽  
Chi Square Test

Abstract Background AF is reported in up to 20% of patients with Chagas, a prevalent disease in Latin-America. PV isolation (PVI) in the cornerstone of AF ablation. However, in Chagas cardiopathy (ChC), microvascular and autonomic abnormalities, atrial fibrosis and sinoatrial dysfunction are possible mechanisms of AF. Therefore, the results of PVI may be different in this subgroup. Objectives To describe long-term results of AF ablation in pts with Chagas versus non-Chagas disease (ChC x NonCh) and evaluate risk factors for post-ablation recurrence. Methods This is a prospective, single-center study that included pts with nonvalvular AF who underwent PVI between 2013 and 2016. All procedures were guided by eletroanatomic mapping and intracardiac echocardiogram. Categorical variables were analyzed using chi-square test and numerical variables with t-student test. Binary logistic regression was performed to identify independent predictors of recurrence of any sustained atrial tachyarrhythmias. Results Ablation was performed in 160 pts (54±15 yo, 59% male): 42 pts with ChC (26%, 62±8 yo) and 118 NonChC (74%, 53±15 yo; p<0,001)). There was no difference in AF type (38x34% paroxysmal, 42x43% persistent, and 19x23% long-term persistent, p=NS) and left atrium diameter (38±5 vs 40±8mm, p=NS). In ChC the mean CHADSVASC score was higher (2.4 vs 1.4, p<0,001) and LVEF was lower (52±18% vs 64±8%, p=0.02). After a follow-up of 31±14 mo and 1.1 ablation per group, recurrence of AF/AT was higher in ChC (33% vs 14%, p=0.03) although more pts with Chagas were on AAD (71 vs 31%, p<0,001). During follow-up, occurrence of embolic events and cardiac or all-cause mortality were not different between groups (0% vs 1.7%, p=NS and 2.4 vs 1.7% p=NS; for ChC vs and NonChC, respectively). At multivariate analysis, long-term persistent AF, hypertension and Chagas disease (HR= 2.21, 3.36 and 3.16, respectively) were independent predictors of recurrence. Conclusions Chagas disease is an independent predictor of recurrence after PVI. Further studies should address which strategy is more appropriate to this group of patients.

scholarly journals Evaluation of Durability of a Single Dose of the Bivalent HPV Vaccine: The CVT Trial

2020 ◽  
Vol 112 (10) ◽  
pp. 1038-1046 ◽  
Author(s):  
Aimée R Kreimer ◽  
Joshua N Sampson ◽  
Carolina Porras ◽  
John T Schiller ◽  
Troy Kemp ◽  
...  
Keyword(s):  
Single Dose ◽  
Hpv Vaccine ◽  
Hpv Vaccination ◽  
Vaccine Trial ◽  
Enzyme Linked Immunosorbent Assay ◽  
Virus Like Particle ◽  
Long Term Follow Up ◽  
Antibody Levels

Abstract Background The authors investigated the durability of vaccine efficacy (VE) against human papillomavirus (HPV)16 or 18 infections and antibody response among nonrandomly assigned women who received a single dose of the bivalent HPV vaccine compared with women who received multiple doses and unvaccinated women. Methods HPV infections were compared between HPV16 or 18-vaccinated women aged 18 to 25 years who received one (N = 112), two (N = 62), or three (N = 1365) doses, and age- and geography-matched unvaccinated women (N = 1783) in the long-term follow-up of the Costa Rica HPV Vaccine Trial. Cervical HPV infections were measured at two study visits, approximately 9 and 11 years after initial HPV vaccination, using National Cancer Institute next-generation sequencing TypeSeq1 assay. VE and 95% confidence intervals (CIs) were estimated. HPV16 or 18 antibody levels were measured in all one- and two-dose women, and a subset of three-dose women, using a virus-like particle-based enzyme-linked immunosorbent assay (n = 448). Results Median follow-up for the HPV-vaccinated group was 11.3 years (interquartile range = 10.9–11.7 years) and did not vary by dose group. VE against prevalent HPV16 or 18 infection was 80.2% (95% CI = 70.7% to 87.0%) among three-dose, 83.8% (95% CI = 19.5% to 99.2%) among two-dose, and 82.1% (95% CI = 40.2% to 97.0%) among single-dose women. HPV16 or 18 antibody levels did not qualitatively decline between years four and 11 regardless of the number of doses given, although one-dose titers continue to be statistically significantly lower compared with two- and three-dose titers. Conclusion More than a decade after HPV vaccination, single-dose VE against HPV16 or 18 infection remained high and HPV16 or 18 antibodies remained stable. A single dose of bivalent HPV vaccine may induce sufficiently durable protection that obviates the need for more doses.

Long-term follow-up of co-infected HIV and Trypanosoma cruzi Brazilian patients

2004 ◽  
Vol 98 (12) ◽  
pp. 728-733 ◽  
Author(s):  
A.M. Da-Cruz ◽  
R.P. Igreja ◽  
W. Dantas ◽  
A.C.V. Junqueira ◽  
R.S. Pacheco ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Long Term Follow Up

scholarly journals The Trypomastigote Small Surface Antigen from Trypanosoma cruzi Improves Treatment Evaluation and Diagnosis in Pediatric Chagas Disease

2017 ◽  
Vol 55 (12) ◽  
pp. 3444-3453 ◽  
Author(s):  
Virginia Balouz ◽  
Luciano J. Melli ◽  
Romina Volcovich ◽  
Guillermo Moscatelli ◽  
Samanta Moroni ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Surface Antigen ◽  
Rapid Assessment ◽  
Drug Efficacy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serological Tests ◽  
Small Surface ◽  
Content Type

ABSTRACTChagas disease is caused by the protozoan parasiteTrypanosoma cruzi. Assessment of parasitological cure upon treatment with available drugs relies on achieving consistent negative results in conventional parasitological and serological tests, which may take years to assess. Here, we evaluated the use of a recombinantT. cruziantigen termed trypomastigote small surface antigen (TSSA) as an early serological marker of drug efficacy inT. cruzi-infected children. A cohort of 78 pediatric patients born toT. cruzi-infected mothers was included in this study. Only 39 of the children were infected withT. cruzi, and they were immediately treated with trypanocidal drugs. Serological responses against TSSA were evaluated in infected and noninfected populations during the follow-up period using an in-house enzyme-linked immunosorbent assay (ELISA) and compared to conventional serological methods. Anti-TSSA antibody titers decreased significantly faster than anti-whole parasite antibodies detected by conventional serology both inT. cruzi-infected patients undergoing effective treatment and in those not infected. The differential kinetics allowed a significant reduction in the required follow-up periods to evaluate therapeutic responses or to rule out maternal-fetal transmission. Finally, we present the case of a congenitally infected patient with an atypical course in whom TSSA provided an early marker forT. cruziinfection. In conclusion, we showed that TSSA was efficacious both for rapid assessment of treatment efficiency and for early negative diagnosis in infants at risk of congenitalT. cruziinfection. Based upon these findings we propose the inclusion of TSSA for refining the posttherapeutic cure criterion and other diagnostic needs in pediatric Chagas disease.

Long-term follow-up of patients with Chagas' disease: Emphasis on the indeterminate form

1999 ◽  
Vol 5 (3) ◽  
pp. 70
Author(s):  
Barbara M. Ianni ◽  
Edmundo Arteaga ◽  
Antonio Carlos Pereira-Barretto ◽  
Charles Mady
Keyword(s):  
Chagas Disease ◽  
Long Term Follow Up ◽  
Indeterminate Form

scholarly journals Long‐Term Follow‐Up of Patients with Chronic Chagas Disease and Implantable Cardioverter‐Defibrillator

2014 ◽  
Vol 37 (6) ◽  
pp. 751-756 ◽  
Author(s):  
FRANCISCA TATIANA MOREIRA PEREIRA ◽  
EDUARDO ARRAIS ROCHA ◽  
MARCELO DE PAULA MARTINS MONTEIRO ◽  
ALMINO CAVALCANTE ROCHA NETO ◽  
ELISABETH DE FRANCESCO DAHER ◽  
...  
Keyword(s):  
Implantable Cardioverter Defibrillator ◽  
Chagas Disease ◽  
Cardioverter Defibrillator ◽  
Long Term Follow Up ◽  
Chronic Chagas Disease

scholarly journals Comparison of Long-Term Fertility and Bleeding Outcomes after Robotic-Assisted, Laparoscopic, and Abdominal Myomectomy

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Rebecca Flyckt ◽  
Enrique Soto ◽  
Benjamin Nutter ◽  
Tommaso Falcone
Keyword(s):  
Chi Square ◽  
Robotic Assisted ◽  
Abdominal Myomectomy ◽  
Spontaneous Pregnancy ◽  
Current Bleeding ◽  
Significant Difference ◽  
Long Term Follow Up

Background/Aims. To compare long-term fertility and bleeding outcomes of women who underwent robotic-assisted, laparoscopic, and abdominal myomectomy at our institution over a 15-year period. Methods. This was a retrospective cohort study of myomectomy patients 18–39 years old that had surgery between January 1995 and December 2009 at our institution. Long-term follow-up on fertility and bleeding outcomes was collected from the patient directly. The uterine fibroid symptom and quality of life survey was also administered to assess current bleeding patterns. Baseline characteristics were compared across groups. Univariable comparisons of fertility and bleeding outcomes based on surgical approach were made using analysis of variance, Kruskal-Wallis analysis of ranks, and Chi-square tests as appropriate. Results. 134/374 (36%) subjects agreed to participate in the study. 81 subjects underwent an open procedure versus 28 and 25 subjects in the laparoscopic and robotic groups, respectively. Median follow-up after surgery was 8 years. 50% of patients desired pregnancy following surgery and, of those, 60% achieved spontaneous pregnancy; the spontaneous pregnancy rate did not differ between groups. Additionally, UFS-QOL scores and/or subscores did not differ between groups. Conclusion. There is no significant difference in long-term bleeding or fertility outcomes in robotic-assisted, laparoscopic, or abdominal myomectomy.

scholarly journals Severe fever with thrombocytopenia syndrome with re-infection in China: a case report

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Shou-Ming Lv ◽  
Chun Yuan ◽  
Lan Zhang ◽  
Yu-Na Wang ◽  
Zi-Niu Dai ◽  
...  
Keyword(s):  
Clinical Findings ◽  
First Episode ◽  
Nucleotide Sequence Analysis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Viral Shedding ◽  
Decay Profile ◽  
Long Term Follow Up ◽  
Severe Fever

Abstract Background Severe fever with thrombocytopenia syndrome (SFTS), an emerging tickborne infectious disease caused by a novel banyangvirus (SFTS virus, SFTSV), was endemic in several Asian countries with a high mortality up to 30%. Until recently, SFTSV-associated re-infection have not been reported and investigated. Case presentation A 42-year-old female patient was identified as a case of SFTS with re-infection, with two episodes of SFTSV infection on June 2018 and May 2020. The diagnosis of SFTS was confirmed by detection of SFTSV RNA in the blood samples using real-time reverse-transcription polymerase chain reaction and antibodies specific for SFTSV using enzyme linked immunosorbent assay. The changes of viremia and antibody response differed between the two episodes. Phylogenetic analysis showed the two viral genome sequences were in the same clade, but showing 0.6% dissimilarity of the nearly whole nucleotide sequence. Analysis of clinical data revealed that the second episode showed milder illness than that of the first episode. Conclusions Epidemiological and clinical findings, viral whole genomic sequences, and serological evidence, provided evidence for the re-infection of SFTSV rather than prolonged viral shedding or relapse of the original infection. The patients with re-infection of SFTSV may be at high odds of clinically inapparent or mildly symptomatic. More attention should be directed towards the long-term follow up of the recovered patients in the future, to explicitly acquire the decay profile of their immunity response. Graphic abstract

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