scholarly journals In-Silico Modeling of the Mitotic Spindle Assembly Checkpoint

PLoS ONE ◽  
2008 ◽  
Vol 3 (2) ◽  
pp. e1555 ◽  
Author(s):  
Bashar Ibrahim ◽  
Stephan Diekmann ◽  
Eberhard Schmitt ◽  
Peter Dittrich
Keyword(s):  
Mitotic Spindle ◽  
In Silico ◽  
Spindle Assembly Checkpoint ◽  
Spindle Assembly ◽  
In Silico Modeling ◽  
Mitotic Spindle Assembly

In silico spatial simulations reveal that MCC formation and excess BubR1 are required for tight inhibition of the anaphase-promoting complex

2015 ◽  
Vol 11 (11) ◽  
pp. 2867-2877 ◽  
Author(s):  
Bashar Ibrahim
Keyword(s):  
Mitotic Spindle ◽  
In Silico ◽  
Spindle Assembly Checkpoint ◽  
Spindle Assembly ◽  
Anaphase Promoting Complex ◽  
Inhibitory Pathways ◽  
Mitotic Spindle Assembly

In response to the activation of the mitotic spindle assembly checkpoint (SAC), distinct inhibitory pathways control the activity of the anaphase-promoting complex (APC/C).

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