scholarly journals Posttranslational Modification of 6-phosphofructo-1-kinase as an Important Feature of Cancer Metabolism

PLoS ONE ◽  
2011 ◽  
Vol 6 (5) ◽  
pp. e19645 ◽  
Author(s):  
Andreja Šmerc ◽  
Eva Sodja ◽  
Matic Legiša
Keyword(s):  
Posttranslational Modification ◽  
Cancer Metabolism

scholarly journals Protein Lipidation by Palmitoylation and Myristoylation in Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Chee Wai Fhu ◽  
Azhar Ali
Keyword(s):  
Structural Stability ◽  
Posttranslational Modification ◽  
Cancer Metabolism ◽  
Lipid Molecule ◽  
Lipid Modifications ◽  
Cancer Initiation ◽  
Recent Developments ◽  
Membrane Compartments ◽  
Lipid Metabolites ◽  
Protein Lipidation

Posttranslational modification of proteins with lipid moieties is known as protein lipidation. The attachment of a lipid molecule to proteins endows distinct properties, which affect their hydrophobicity, structural stability, localization, trafficking between membrane compartments, and influences its interaction with effectors. Lipids or lipid metabolites can serve as substrates for lipidation, and the availability of these lipid substrates are tightly regulated by cellular metabolism. Palmitoylation and myristoylation represent the two most common protein lipid modifications, and dysregulation of protein lipidation is strongly linked to various diseases such as metabolic syndromes and cancers. In this review, we present recent developments in our understanding on the roles of palmitoylation and myristoylation, and their significance in modulating cancer metabolism toward cancer initiation and progression.

Neurofilaments and Paired Helical Filaments

1985 ◽  
Vol 43 ◽  
pp. 740-743
Author(s):  
J. Metuzals
Keyword(s):  
Animal Model ◽  
Posttranslational Modifications ◽  
Posttranslational Modification ◽  
Giant Axon ◽  
Paired Helical Filaments ◽  
Squid Giant Axon ◽  
In Vitro Experiments ◽  
Thin Sections ◽  
Structural Relationships

It has been demonstrated that the neurofibrillary tangles in biopsies of Alzheimer patients, composed of typical paired helical filaments (PHF), consist also of typical neurofilaments (NF) and 15nm wide filaments. Close structural relationships, and even continuity between NF and PHF, have been observed. In this paper, such relationships are investigated from the standpoint that the PHF are formed through posttranslational modifications of NF. To investigate the validity of the posttranslational modification hypothesis of PHF formation, we have identified in thin sections from frontal lobe biopsies of Alzheimer patients all existing conformations of NF and PHF and ordered these conformations in a hypothetical sequence. However, only experiments with animal model preparations will prove or disprove the validity of the interpretations of static structural observations made on patients. For this purpose, the results of in vitro experiments with the squid giant axon preparations are compared with those obtained from human patients. This approach is essential in discovering etiological factors of Alzheimer's disease and its early diagnosis.

Molecular pathways of Interferon–Stimulated Gene 15: Implications in cancer

2020 ◽  
Vol 21 ◽  
Author(s):  
Angeles C. Tecalco–Cruz
Keyword(s):  
Posttranslational Modification ◽  
Human Interferon ◽  
Molecular Pathways ◽  
Biological Processes ◽  
Small Protein ◽  
Target Proteins ◽  
Central Elements ◽  
Cancer Types ◽  
Interferon Stimulated Gene 15

Abstract:: Human interferon–stimulated gene 15 (ISG15) is a 15–kDa ubiquitin–like protein that can be detected as either free ISG15 or covalently associated with its target proteins through a process termed ISGylation. Interestingly, extracellular free ISG15 has been proposed as a cytokine–like protein, whereas ISGylation is a posttranslational modification. ISG15 is a small protein with implications in some biological processes and pathologies that include cancer. This review highlights the findings of both free ISG15 and protein ISGylation involved in several molecular pathways, emerging as central elements in some cancer types.

Antiangiogenic Resistance and Cancer Metabolism: Opportunities for Synthetic Lethality

2016 ◽  
Vol 17 (15) ◽  
pp. 1714-1727 ◽  
Author(s):  
Simon Lord ◽  
Juan M. Funes ◽  
Adrian L Harris ◽  
Miguel Quintela-Fandino
Keyword(s):  
Cancer Metabolism ◽  
Synthetic Lethality
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