:
Metabolic reprogramming is a significant property of various cancer cells, which most commonly
arises from the Tumor Microenvironment (TME). The events of metabolic pathways include the Warburg effect,
shifting in Krebs cycle metabolites, and the rate of oxidative phosphorylation, potentially providing energy and
structural requirements for the development and invasiveness of cancer cells. TME and tumor metabolism shifting
have a close relationship through bidirectional signaling pathways between stromal and tumor cells. Cancer-
Associated Fibroblasts (CAFs), as the most dominant cells of TME, play a crucial role in the aberrant metabolism
of cancer. Furthermore, the stated relationship can affect survival, progression, and metastasis in cancer
development. Recently, exosomes are considered one of the most prominent factors in cellular communications
considering effective content and bidirectional mediatory effect between tumor and stromal cells. In this regard,
CAF-Derived Exosomes (CDE) exhibit an efficient obligation to induce metabolic reprogramming for promoting
growth and metastasis of cancer cells. The understanding of cancer metabolism, including factors related to
TME, could lead to the discovery of a potential biomarker for diagnostic and therapeutic approaches in cancer
management. This review focuses on the association between metabolic reprogramming and engaged microenvironmental,
factors such as CAFs, and the associated derived exosomes.
Editorial: Cancer Metabolism: Molecular Targeting and Implications for Therapy
