scholarly journals EEG Microstate Analysis in Drug-Naive Patients with Panic Disorder

PLoS ONE ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. e22912 ◽  
Author(s):  
Mitsuru Kikuchi ◽  
Thomas Koenig ◽  
Toshio Munesue ◽  
Akira Hanaoka ◽  
Werner Strik ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Drug Naïve ◽  
Microstate Analysis

scholarly journals Abnormalities of EEG Microstates In Drug-Naïve, First-Episode Schizophrenia

2021 ◽  
Author(s):  
Qiaoling Sun ◽  
Linlin Zhao ◽  
Liwen Tan
Keyword(s):  
Clinical Symptoms ◽  
Early Stage ◽  
First Episode ◽  
Healthy Controls ◽  
Brain Functions ◽  
Class D ◽  
Syndrome Scale ◽  
Drug Naïve ◽  
Microstate Analysis ◽  
First Episode Schizophrenia

Abstract Objective: Microstate analysis is a powerful tool to probe the brain functions, and changes in microstates under electroencephalography (EEG) have been repeatedly reported in patients with schizophrenia. This study aimed to investigate the dynamics of EEG microstates in drug-naïve, first-episode schizophrenia (FE-SCH) and to test the relationship between EEG microstates and clinical symptoms.Methods: Resting-state EEG were recorded for 23 patients with FE-SCH and 23 healthy controls using a 64-channel cap. Three parameters, i.e., contribution, duration, and occurrence, of the four microstate classes were calculated. Group differences in EEG microstates and their clinical symptoms (assessed using the Positive and Negative Syndrome Scale) were analyzed.Results: Compared with healthy controls, patients with FE-SCH showed increased duration, occurrence and contribution of microstate class C and decreased contribution and occurrence of microstate class D. In addition, the score of positive symptoms in PANSS was negatively correlated with the occurrence of microstate D.Conclusions: Our findings showed abnormal patterns of EEG microstates in drug-naïve, first-episode schizophrenia, which might help distinguish individuals with schizophrenia in the early stage and develop early intervention strategies.

Subcortical structural abnormalities of first onset drug naïve major depressive disorder with panic disorder patients

2011 ◽  
Vol 26 (S2) ◽  
pp. 936-936
Author(s):  
C.-H. Lai
Keyword(s):  
Major Depressive Disorder ◽  
Panic Disorder ◽  
Depressive Disorder ◽  
Rating Scales ◽  
Surface Model ◽  
Subcortical Structures ◽  
Major Depressive ◽  
Clinical Rating ◽  
Structural Abnormalities ◽  
Drug Naïve

ObjectiveThis study was designed to apply subcortical analysis of first episode drug naïve major depressive disorder with panic disorder patients.MethodAll the participating subjects received scales rating for depression and panic disorder. 15 patients and 15 healthy controls were compared to explore the differences of subcortical structures, such as hippocampus, putamen and thalamus. A new semi-automatic toolbox for computing subcortical areas by a shape and surface model was utilized for the comparison. The volumes of subcortical structures were also compared by using nonparametric t test of SPSS software to support the findings from the FSL FIRST toolbox (FMRIB Software Library, FMRIB's Integrated Registration and Segmentation Tool).ResultsThe patient group had significantly lower volumes in the left hippocampus, thalamus and putamen. The volumetric differences were also significant in these areas (2 tailed p < 0.05; Mann-Whitney U test). The volumes of thalamus and putamen were also well correlated with clinical rating scales. The relationship between left hippocampal volumes and clinical rating scales was modest. The volumes of right hippocampus were not correlated with clinical rating scales.ConclusionsThe structural abnormalities of putamen and thalamus might represent a specific pathology for major depressive disorder co-morbid with panic disorder. The limited deficits of hippocampal volumes should represent an intermediate type between major depressive disorder and panic disorder. The co-morbidity might have a different subcortical pathology.

scholarly journals Brain Circulation during Panic Attack: A Transcranial Doppler Study with Clomipramine Challenge

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Francesco Rotella ◽  
Marinella Marinoni ◽  
Francesca Lejeune ◽  
Fabiana Alari ◽  
Daniela Depinesi ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Transcranial Doppler ◽  
Panic Attack ◽  
Cerebral Arteries ◽  
Mean Flow ◽  
Middle Cerebral Arteries ◽  
History Of ◽  
Drug Naïve ◽  
Left Middle ◽  
Flow Velocities

Introduction. Cerebral blood flow has been well studied in patients with panic disorder, but only few studies analyzed the mechanisms underlying the onset of a panic attack. The aim of the present study was to monitor the cerebral hemodynamics modifications during a panic attack.Materials and Methods. 10 panic disorder patients with recent onset, fully drug naïve, were compared to 13 patients with panic disorder with a previous history of treatment and to 14 controls. A continuous bilateral monitoring of mean flow velocities in right and left middle cerebral arteries was performed by transcranial Doppler. Clomipramine was chosen as challenge.Results. Eight out of 10 patients drug naïve and 6 control subjects out of 13 had a full blown panic attack during the test, whereas none of the patients with a history of treatment panicked. The occurrence of a panic attack was accompanied by a rapid decrease of flow velocities in both right and left middle cerebral arteries.Discussion. The bilateral acute decrease of mean flow velocity during a panic attack suggests the vasoconstriction of the microcirculation of deep brain structures perfused by middle cerebral arteries and involved in the so-called “fear circuitry,” thus suggesting that cerebral homeostatic dysfunctions seem to have a key role in the onset of a panic attack.

Sign in / Sign up

Export Citation Format

Share Document