scholarly journals Effects of Ligands on Unfolding of the Amyloid β-Peptide Central Helix: Mechanistic Insights from Molecular Dynamics Simulations

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e30510 ◽  
Author(s):  
Mika Ito ◽  
Jan Johansson ◽  
Roger Strömberg ◽  
Lennart Nilsson
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Central Helix ◽  
Dynamics Simulations

Destabilization of Alzheimer’s Aβ42 protofibrils with acyclovir, carmustine, curcumin, and tetracycline: Insights from molecular dynamics simulations

2021 ◽  
Author(s):  
Ishrat Jahan ◽  
Shahid M Nayeem
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Dynamics ◽  
Neurodegenerative Diseases ◽  
Molecular Dynamics Simulations ◽  
Amyloid Β ◽  
Neural Tissue ◽  
Amyloid Β Peptide ◽  
Characteristic Symptom ◽  
Dynamics Simulations

One of the most common dementia among neurodegenerative diseases is Alzheimer’s disease (AD). The characteristic symptom of AD is the deposition and aggregation of amyloid-β-peptide in the neural tissue. A...

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