scholarly journals Substrate Stiffness and Oxygen as Regulators of Stem Cell Differentiation during Skeletal Tissue Regeneration: A Mechanobiological Model

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e40737 ◽  
Author(s):  
Darren Paul Burke ◽  
Daniel John Kelly
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Tissue Regeneration ◽  
Stem Cell Differentiation ◽  
Substrate Stiffness ◽  
Skeletal Tissue

scholarly journals Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration: A Focus on Muscular Dystrophy

2015 ◽  
Vol 11 (6) ◽  
pp. 866-884 ◽  
Author(s):  
Serge Ostrovidov ◽  
Xuetao Shi ◽  
Ramin Banan Sadeghian ◽  
Sahar Salehi ◽  
Toshinori Fujie ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Muscular Dystrophy ◽  
Muscle Tissue ◽  
Tissue Regeneration ◽  
Stem Cell Differentiation ◽  
Myogenic Lineage

Chitosan stabilizes platelet growth factors and modulates stem cell differentiation toward tissue regeneration

2013 ◽  
Vol 98 (1) ◽  
pp. 665-676 ◽  
Author(s):  
Alberto Busilacchi ◽  
Antonio Gigante ◽  
Monica Mattioli-Belmonte ◽  
Sandra Manzotti ◽  
Riccardo A.A. Muzzarelli
Keyword(s):  
Stem Cell ◽  
Growth Factors ◽  
Cell Differentiation ◽  
Tissue Regeneration ◽  
Stem Cell Differentiation

Could Substrate Stiffness and Oxygen Tension Regulate Stem Cell Differentiation During Fracture Healing?

2011 ◽  
Author(s):  
D. Burke ◽  
D. J. Kelly
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Fracture Healing ◽  
Oxygen Tension ◽  
Temporal Patterns ◽  
Stem Cell Differentiation ◽  
Tissue Differentiation ◽  
Substrate Stiffness ◽  
Spatial And Temporal Patterns ◽  
Msc Differentiation

Extrinsic mechanical signals have been implicated as key regulators of Mesenchymal Stem Cell (MSC) differentiation [1]. It has been possible to test different hypotheses for mechano-regulated differentiation by attempting to simulate regenerative events such as bone fracture repair [2]. During such events, repeatable spatial and temporal patterns of tissue differentiation occur. More recently, in vitro studies have identified other environmental cues, such as substrate stiffness [3] and oxygen tension [4], as key regulators of MSC differentiation. The hypothesis of this study is that a computational model that assumes substrate stiffness and oxygen tension regulate stem cell differentiation can be used to predict the spatial and temporal patterns of tissue differentiation that occur during fracture healing.

Embryonic Stem Cell Differentiation to Cardiomyocytes on Nanostructured Scaffolds for Myocardial Tissue Regeneration

2013 ◽  
Vol 63 (5) ◽  
pp. 240-245 ◽  
Author(s):  
Laleh Ghasemi-Mobarakeh ◽  
Molamma P. Prabhakaran ◽  
Marziyeh Nematollahi ◽  
Khadijeh Karbalaie ◽  
Seeram Ramakrishna ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Embryonic Stem Cell ◽  
Tissue Regeneration ◽  
Embryonic Stem ◽  
Stem Cell Differentiation ◽  
Myocardial Tissue ◽  
Embryonic Stem Cell Differentiation
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