scholarly journals Approaches to Brain Stress Testing: BOLD Magnetic Resonance Imaging with Computer-Controlled Delivery of Carbon Dioxide

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e47443 ◽  
Author(s):  
W. Alan C. Mutch ◽  
Daniel M. Mandell ◽  
Joseph A. Fisher ◽  
David J. Mikulis ◽  
Adrian P. Crawley ◽  
...  
1998 ◽  
Vol 88 (4) ◽  
pp. 984-992 ◽  
Author(s):  
Jean-Francois Payen ◽  
Albert Vath ◽  
Blanche Koenigsberg ◽  
Virginie Bourlier ◽  
Michel Decorps

Background Noninvasive techniques used to determine the changes in cerebral blood volume in response to carbon dioxide are hampered by their limited spatial or temporal resolution or both. Using steady state contrast-enhanced magnetic resonance imaging, the authors determined regional changes in cerebral plasma volume (CPV) induced by hypercapnia in halothane-anesthetized rats. Methods Cerebral plasma volume was determined during normocapnia, hypercapnia and recovery in the dorsoparietal neocortex and striatum of each hemisphere, in cerebellum, and in extracerebral tissue of rats with either intact carotid arteries (group 1) or unilateral common carotid ligation (group 2). Another group was studied without injection of a contrast agent (group 3). Results Hypercapnia (partial pressure of carbon dioxide in arterial blood [PaCO2] approximately 65 mmHg) resulted in a significant increase in CPV in the striatum (+42 +/- 8%), neocortex (+34 +/- 6%), and cerebellum (+49 +/- 12%) compared with normocapnic CPV values (group 1). Carotid ligation (group 2) led to a marked reduction of the CPV response to hypercapnia in the ipsilateral striatum (+23 +/- 14%) and neocortex (+27 +/- 17%) compared with the unclamped side (+34 +/- 15% and +38 +/- 16%, respectively). No significant changes in CPV were found in extracerebral tissue. In both groups, the CPV changes were reversed by the carbon dioxide washout period. Negligible changes in contrast imaging were detected during hypercapnia without administration of the contrast agent (group 3). Conclusions The contrast-enhanced magnetic resonance imaging technique is sensitive to detect noninvasively regional CPV changes induced by hypercapnia in rat brain. This could be of clinical interest for determining the cerebrovascular reactivity among different brain regions.


SPE Journal ◽  
2018 ◽  
Vol 23 (03) ◽  
pp. 772-787 ◽  
Author(s):  
Armin Afrough ◽  
M.. Shakerian ◽  
M. S. Zamiri ◽  
Bryce MacMillan ◽  
Florea Marica ◽  
...  

Summary Magnetic-resonance imaging (MRI) provides a wealth of information on petroleum-flooding-displacement mechanisms and in-situ pore-level behavior. This study demonstrates MRI methods that have potential for studying the mechanisms of carbon dioxide (CO2) displacement processes in Berea core plugs during the recovery of decane and heavy oil. The correlation between fluid saturation and transverse relaxation time (T2) revealed the contrast in decane/pore-surface interaction between miscible and immiscible drainage of decane by CO2. T2 profiles demonstrated changes in the composition and viscosity of the heavy oil caused by the extraction of light components by CO2.


2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Carissa L Patete ◽  
Michael Plastini ◽  
Prakash J Mathew ◽  
Jason J Yoo ◽  
Zubin Panthaki

Abstract Implant-based reconstruction is the most common form of breast reconstruction following mastectomy. It is most often performed in 2 stages using saline-based tissue expanders, which are then exchanged for permanent implants. Serial expansions are performed by accessing a port in the office, an inconvenient and sometimes painful process. A carbon dioxide tissue expander is a device that provides a needle-free, patient-controlled expansion utilizing a remote-controlled CO2 canister. While a patient-controlled expansion offers convenience, given that the CO2 reservoir holds approximately 1500 mL of gas, the potential for malfunction resulting in an uncontrolled expansion in unique to this device. The authors present a case report of a patient with bilateral pre-pectoral tissue expanders who underwent magnetic resonance imaging, resulting in uncontrolled expansion. Level of Evidence: 5


1995 ◽  
Vol 104 (7) ◽  
pp. 522-528 ◽  
Author(s):  
J. Douglas Swarts ◽  
Cuneyt M. Alper ◽  
Kenny H. Chan ◽  
James T. Seroky ◽  
William J. Doyle

In this study, magnetic resonance imaging (MRI) was used to define, in vivo, the effect of acute middle ear (ME) underpressures on vascular permeability and the development of effusion. The MEs of four cynomolgus monkeys were unilaterally inflated with oxygen and carbon dioxide on different occasions and followed for a period of approximately 4 hours by tympanometry and MRI scanning. Carbon dioxide inflations caused the rapid development of ME underpressures of less than −600 mm H2O by 10 minutes. The MRI scans showed a progressive brightening of the ME and all associated air cells, indicative of the accumulation of effusion in three of the four experiments. An MRI contrast agent was administered to the vascular compartment during the course of the experiment and was rapidly transferred to the ME space, indicating vascular permeability to the agent. The contralateral, control side did not develop significant underpressures, effusion, or increased vascular permeability. Inflation with oxygen caused lesser underpressures and no accompanying changes in the MRI scans. These data support the hydrops ex vacuo theory and confirm the usefulness of MRI for in vivo documentation of the development of ME effusions and changes in vascular permeability of the mucosa in the experimental setting.


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